Template:Keywords: Coupling control: Difference between revisions

Revision as of 01:40, 12 November 2020

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The Blue Book 2020
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OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
(P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.

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Respiratory rate	Definition
OXPHOS capacity	P = P´-Rox
ROUTINE respiration	R = R´-Rox
ET capacity	E = E´-Rox	» Level flow
		» Noncoupled respiration - Uncoupler^[1]
LEAK respiration	L = L´-Rox	» Static head
		» LEAK state with ATP
		» LEAK state with oligomycin
		» LEAK state without adenylates
Residual oxygen consumption Rox	L = L´-Rox

FCR	Definition
L/P coupling-control ratio	L/P	» Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio	L/R
L/E coupling-control ratio	L/E	» Uncoupling-control ratio, UCR = E/L
P/E control ratio	P/E
R/E control ratio	R/E
net P/E control ratio	(P-L)/E
net R/E control ratio	(R-L)/E

Coupling-control efficiency		Definition
P-L OXPHOS-coupling efficiency	j_P-L	= (P-L)/P	= 1-L/P	» Biochemical coupling efficiency
R-L ROUTINE-coupling efficiency	j_R-L	= (R-L)/R	= 1-L/R
E-L ET-coupling efficiency	j_E-L	= (E-L)/E	= 1-L/E	» Biochemical coupling efficiency
E-P excess control efficiency	j_E-P	= (E-P)/E	= 1-P/E
E-R reserve control efficiency	j_E-R	= (E-R)/E	= 1-R/E

↑ Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »Uncoupler«

@@ Line 72: / Line 72: @@
 | [[E-L net ET capacity |''E-L'' net ET capacity]] || ''E-L'' || [[Image:E-L.jpg|50 px|link=E-L net ET capacity |''E-L'' net ET capacity]]
 |-
-| [[E-P excess ET capacity |''E-P'' excess ET capacity]] || ''E-P'' || [[Image:E-P.jpg|60 px|link=E-P excess ET capacity |''E-P'' excess ET capacity]]
+| [[E-P excess capacity |''E-P'' excess capacity]] || ''E-P'' || [[Image:E-P.jpg|60 px|link=E-P excess capacity |''E-P'' excess capacity]]
 |-
-| [[E-R reserve ET capacity |''E-R'' reserve ET capacity]] || ''E-R'' || [[Image:E-R.jpg|60 px|E-R reserve ET capacity |''E-R'' reserve ET capacity]]
+| [[E-R reserve capacity |''E-R'' reserve capacity]] || ''E-R'' || [[Image:E-R.jpg|60 px|E-R reserve capacity |''E-R'' reserve capacity]]
 |}