R/E control ratio

high-resolution terminology - matching measurements at high-resolution

R/E control ratio

Description

The ROUTINE control ratio (R/E coupling control ratio) is the ratio of (partially coupled) ROUTINE respiration and (noncoupled) ET capacity. The R/E control ratio is an expression of how close ROUTINE respiration operates to ET capacity.

Abbreviation: R/E

Reference: Gnaiger 2014 MitoPathways

MitoPedia concepts: Respiratory control ratio 

Boundaries of the ROUTINE control ratio

R/E increases due to (i) high ATP demand and ADP-stimulated ROUTINE respiration, (ii) partial uncoupling, and (iii) limitation of oxidative capacity by defects of substrate oxidation and complexes of the ET-pathway. The corresponding inverse ratio is the uncoupling control ratio, UCR, which can be seen as an index of apparent ET-pathway excess capacity. The lower boundary of R/E is the L/E flux control ratio, whereas the upper boundary is set by the P/E flux control ratio (OXPHOS/ET capacity).

Biochemical coupling efficiency: from 0 to <1

• More details: »Biochemical coupling efficiency

Compare:

• Excess E-R capacity factor, j_ExR = (E-R)/E = 1-R/E
• ROUTINE coupling efficiency, j_≈R = ≈R/R = (R-L)/R = 1-L/R
• NetROUTINE control ratio, ≈R/E = (R-L)/E