E-L net ET capacity: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=''E-L'' | |abbr=''E-L'' | ||
|description=[[Image:E-L.jpg|50 px| | |description=[[Image:E-L.jpg|50 px|Net ET-capacity E-L]] The '''net ET-capacity E-L''', ''E-L'', is the [[ET-capacity]] corrected for [[LEAK-respiration]]. ''E-L'' is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the net ET-capacity ''E-L'', and LEAK-respiration, ''L<sub>P</sub>'', compensating for proton leaks, slip and cation cycling: ''E'' = ''E-L''+''L<sub>P</sub>'' (see [[Net OXPHOS-capacity P-L]]). | ||
|info=[[Gnaiger 2020 MitoPathways]] | |info=[[Gnaiger 2020 MitoPathways]] | ||
}} | }} | ||
ย Communicated by [[Gnaiger E]] (2014-09-21) last upate 2020-11-07. | ย Communicated by [[Gnaiger E]] (2014-09-21) last upate 2020-11-07. | ||
== | == Keywords == | ||
{{Template:Keywords: Coupling control}} | |||
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Revision as of 03:18, 9 November 2020
Description
The net ET-capacity E-L, E-L, is the ET-capacity corrected for LEAK-respiration. E-L is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the net ET-capacity E-L, and LEAK-respiration, LP, compensating for proton leaks, slip and cation cycling: E = E-L+LP (see Net OXPHOS-capacity P-L).
Abbreviation: E-L
Reference: Gnaiger 2020 MitoPathways
Communicated by Gnaiger E (2014-09-21) last upate 2020-11-07.
Keywords
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation Pยป (ADP to ATP) without competing with Pยป.
- Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
1. Mitochondrial and cellular respiratory rates in coupling-control states
Respiratory rate | Defining relations | Icon | |
---|---|---|---|
OXPHOS capacity | P = Pยด-Rox | mt-preparations | |
ROUTINE respiration | R = Rยด-Rox | living cells | |
ET capacity | E = Eยด-Rox | ยป Level flow | |
ยป Noncoupled respiration - Uncoupler | |||
LEAK respiration | L = Lยด-Rox | ยป Static head | |
ยป LEAK state with ATP | |||
ยป LEAK state with oligomycin | |||
ยป LEAK state without adenylates | |||
Residual oxygen consumption Rox | L = Lยด-Rox |
2. Flux control ratios related to coupling in mt-preparations and living cells
FCR | Definition | Icon | |
---|---|---|---|
L/P coupling-control ratio | L/P | ยป Respiratory acceptor control ratio, RCR = P/L | |
L/R coupling-control ratio | L/R | ||
L/E coupling-control ratio | L/E | ยป Uncoupling-control ratio, UCR = E/L (ambiguous) | |
P/E control ratio | P/E | ||
R/E control ratio | R/E | ยป Uncoupling-control ratio, UCR = E/L | |
net P/E control ratio | (P-L)/E | ||
net R/E control ratio | (R-L)/E |
3. Net, excess, and reserve capacities of respiration
Respiratory net rate | Definition | Icon |
---|---|---|
P-L net OXPHOS capacity | P-L | |
R-L net ROUTINE capacity | R-L | |
E-L net ET capacity | E-L | |
E-P excess capacity | E-P | |
E-R reserve capacity | E-R |
4. Flux control efficiencies related to coupling-control ratios
- ยป Flux control efficiency jZ-Y
- ยป Background state
- ยป Reference state
- ยป Metabolic control variable
Coupling-control efficiency | Definition | Icon | Canonical term | ||
---|---|---|---|---|---|
P-L control efficiency | jP-L | = (P-L)/P | = 1-L/P | P-L OXPHOS-flux control efficiency | |
R-L control efficiency | jR-L | = (R-L)/R | = 1-L/R | R-L ROUTINE-flux control efficiency | |
E-L coupling efficiency | jE-L | = (E-L)/E | = 1-L/E | E-L ET-coupling efficiency ยป Biochemical coupling efficiency | |
E-P control efficiency | jE-P | = (E-P)/E | = 1-P/E | E-P ET-excess flux control efficiency | |
E-R control efficiency | jE-R | = (E-R)/E | = 1-R/E | E-R ET-reserve flux control efficiency |
5. General
- ยป Basal respiration
- ยป Cell ergometry
- ยป Dyscoupled respiration
- ยป Dyscoupling
- ยป Electron leak
- ยป Electron-transfer-pathway state
- ยป Hyphenation
- ยป Oxidative phosphorylation
- ยป Oxygen flow
- ยป Oxygen flux
- ยป Permeabilized cells
- ยป Phosphorylation system
- ยป Proton leak
- ยป Proton slip
- ยป Respiratory state
- ยป Uncoupling