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ASK Query
[[Category:Publications]] [[Pathways::F]]
SQL Query
SELECT DISTINCT
  t0.smw_id AS id,
  t0.smw_title AS t,
  t0.smw_namespace AS ns,
  t0.smw_iw AS iw,
  t0.smw_subobject AS so,
  t0.smw_sortkey AS sortkey, t0.smw_sort
FROM
  `smw_object_ids` AS t0
INNER JOIN
  (`smw_fpt_inst` AS t2
INNER JOIN
  `t3` AS t3 ON t2.o_id=t3.id
INNER JOIN
  `smw_di_blob` AS t4 ON t2.s_id=t4.s_id) ON t0.smw_id=t2.s_id
WHERE
  (
   ((t4.o_hash='F') AND t4.p_id=80959)
  )
  AND t0.smw_iw!=':smw'
  AND t0.smw_iw!=':smw-delete'
  AND t0.smw_iw!=':smw-redi'
ORDER BY
  t0.smw_sort ASC
LIMIT
  55
OFFSET
  500
SQL Explain
IDselect_typetabletypepossible_keyskeykey_lenrefrowsfilteredExtra
1SIMPLEt4refs_id, p_id, s_id_2, o_hashp_id262const, const755100.00Using index condition; Using temporary; Using filesort
Auxilliary Tables
  • Temporary table t3
      Recursively computed hierarchy for element(s) (80971).
      SELECT s_id FROM `smw_fpt_subc` WHERE o_id=80971 LIMIT 1
Query Metrics
Query-Size:3
Query-Depth:1
Errors and Warnings
None
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Nelskylae 2017 Resuscitation2017Nelskylä A, Nurmi J, Jousi M, Schramko A, Mervaala E, Ristagno G, Skrifvars MB (2017) The effect of 50% compared to 100% inspired oxygen fraction on brain oxygenation and post cardiac arrest mitochondrial function in experimental cardiac arrest. Resuscitation 116:1-7.OXPHOS
ET
F
N
S
NS
HomogenatePigHeart
Nemec 2017 Abstract MITOEAGLE Barcelona
COST Action MITOEAGLE

Functional state of mitochondria in patients with preclinical cognitive deficit.

OXPHOS
ET
FPermeabilized tissueHumanSkeletal muscle
Nemec 2018 MiP2018
Michal Nemec

Aerobic/strength exercise intervention modulates skeletal muscle mitochondrial function in seniors.

LEAKF
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Neviere 2015 Fatty Acid Oxidation O2k-Network Discussion ForumNeviere 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueHuman
Mouse
Newell 2016 Physiol Entomol2016Newell C, Kane CL, Kane DC (2016) Mitochondrial substrate specificity in beetle flight muscle: assessing respiratory oxygen flux in small samples from Dermestes maculatus and Tenebrio molitor. Physiol Entomol p7.OXPHOSF
N
Gp
Other combinations
Permeabilized tissueHexapodsSkeletal muscle
Newsom 2017 Am J Physiol Endocrinol Metab2017Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Newsom 2021 Med Sci Sports Exerc2021Newsom SA, Stierwalt HD, Ehrlicher SE, Robinson MM (2021) Substrate-specific respiration of isolated skeletal muscle mitochondria after 1 h of moderate cycling in sedentary adults. https://doi.org/10.1249/mss.0000000000002615LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaHumanSkeletal muscle
Nijholt 2023 Sci Rep2023Nijholt KT, Sánchez-Aguilera PI, Mahmoud B, Gerding A, Wolters JC, Wolters AHG, Giepmans BNG, Silljé HHW, de Boer RA, Bakker BM, Westenbrink BD (2023) A Kinase Interacting Protein 1 regulates mitochondrial protein levels in energy metabolism and promotes mitochondrial turnover after exercise. https://doi.org/10.1038/s41598-023-45961-zLEAK
OXPHOS
ET
F
N
Isolated mitochondriaMouseHeart
Nollet 2023 Eur Heart J2023Nollet EE, Duursma I, Rozenbaum A, Eggelbusch M, Wüst RCI, Schoonvelde SAC, Michels M, Jansen M, van der Wel NN, Bedi KC, Margulies KB, Nirschl J, Kuster DWD, van der Velden J (2023) Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration. https://doi.org/10.1093/eurheartj/ehad028LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanHeart
Noone 2023 Cell Signal2023Noone J, Rochfort KD, O'Sullivan F, O'Gorman DJ (2023) SIRT4 is a regulator of human skeletal muscle fatty acid metabolism influencing inner and outer mitochondrial membrane-mediated fusion. https://doi.org/10.1016/j.cellsig.2023.110931LEAK
OXPHOS
F
N
ROX
Permeabilized cellsHumanSkeletal muscle
Nsiah-Sefaa 2016 Biosci Rep2016Nsiah-Sefaa A, McKenzie M (2016) Combined defects in oxidative phosphorylation and fatty acid β-oxidation in mitochondrial disease. Biosci Rep 36:e00313. https://doi.org/10.1042/BSR20150295F
O'Brien 2017 Abstract IOC122PPARα independent effects of nitrate supplementation on skeletal muscle mitochondrial function in hypoxia.LEAK
OXPHOS
FMouseSkeletal muscle
Oemer 2018 Proc Nat Acad Sci U S A2018Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Ofer 2015 Mol Endocrinol2015Ofer P, Heidegger I, Eder IE, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P (2015) Both IGF1R and INSR knockdown exert anti-tumorigenic effects in prostate cancer in vitro and in vivo. Mol Endocrinol 29:1694-707.ROUTINE
OXPHOS
ET
F
N
NS
Permeabilized cells
Intact cells
HumanGenital
Other cell lines
Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOjuka 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOXPHOS
ET
FPermeabilized tissue
Ojuka 2016 Am J Physiol Endocrinol Metab2016Ojuka E, Andrew B, Bezuidenhout N, George S, Maarman G, Madlala HP, Mendham A, Osiki PO (2016) Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. Am J Physiol Endocrinol Metab 310:E715-23. https://doi.org/10.1152/ajpendo.00475.2015LEAK
OXPHOS
ET
FPermeabilized tissue
Isolated mitochondria
Human
Mouse
Rat
Skeletal muscle
Liver
Oliveira 2016 PLOS ONE2016Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429.LEAK
ROUTINE
F
ROX
Intact organismOther invertebrates
Oliveira MF 2013 Abstract MiP2013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Permeabilized cells
Permeabilized tissue
Homogenate
Intact cells
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Osiki 2016 Abstract MitoFit Science Camp 2016Suitability of octanoylcarnitine & malate for assessment of beta oxidation capacity by respirometry in aconitase-inhibited samples.OXPHOS
ET
F
N
Other combinations
RatSkeletal muscle
Osiki 2016 FASEB J2016Osiki PO, Ojuka E, Marmaan G (2016) An investigation of the suitability of using octanoylcarnitine together with malate as a substrate combination for assessing Beta-oxidation using High Resolution Respirometry. FASEB J 30: 1015.12 .LEAK
OXPHOS
ET
FPermeabilized tissueRatSkeletal muscle
Ost 2014 PLoS One2014Ost M, Werner F, Dokas J, Klaus S, Voigt A (2014) Activation of AMPKa2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. PLoS One 14:e94689.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Ost 2015 Fatty Acid Oxidation O2k-Network Discussion ForumOst 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissueMouseSkeletal muscle
Paglialunga 2015 Diabetologia2015Paglialunga S, Ludzki A, Root-McCaig J, Holloway GP (2015) In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice. Diabetologia 58:1071-80.LEAK
OXPHOS
F
N
Permeabilized tissueMouseFat
Pajuelo-Reguera 2011 Br J Nutr2011Pajuelo-Reguera D, Quesada H, Díaz S, Fernández-Iglesias A, Arola-Arnal A, Bladé C, Salvadó J, Arola L (2011) Chronic dietary supplementation of proanthocyanidins corrects the mitochondrial dysfunction of brown adipose tissue caused by diet-induced obesity in Wistar rats. Br J Nutr 28:1-9.LEAK
OXPHOS
ET
F
N
Isolated mitochondriaRatFat
Palacka 2021 Int J Mol Sci2021Palacka P, Gvozdjáková A, Rausová Z, Kucharská J, Slopovský J, Obertová J, Furka D, Furka S, Singh KK, Sumbalová Z (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. https://doi.org/10.3390/ijms23010388LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Palavicini 2020 JCI Insight2020Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseNervous system
Palm 2015 Fatty Acid Oxidation O2k-Network Discussion ForumPalm 2015 Fatty Acid Oxidation O2k-Network Discussion ForumF
Pambianco 2016 Cell Rep2016Pambianco S, Giovarelli M, Perrotta C, Zecchini S, Cervia D3, Di Renzo I, Moscheni C, Ripolone M, Violano R, Moggio M, Bassi MT, Puri PL, Latella L, Clementi E, De Palma C (2016) Reversal of defective mitochondrial biogenesis in limb-girdle muscular dystrophy 2D by independent modulation of histone and PGC-1α acetylation. Cell Rep 17:3010-23.LEAK
OXPHOS
F
N
S
NS
ROX
Permeabilized cells
Isolated mitochondria
Permeabilized tissue
MouseSkeletal muscle
Park 2018 J Clin Invest2018Park H, He A, Tan M, Johnson JM, Dean JM, Pietka TA, Chen Y, Zhang X, Hsu FF, Razani B, Funai K, Lodhi IJ (2018) Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission. J Clin Invest 129:694-711.OXPHOS
ET
LEAK
F
N
S
Permeabilized tissueMouseFat
Pasdois 2015 Fatty Acid Oxidation O2k-Network Discussion ForumCannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumFPermeabilized tissue
Isolated mitochondria
Patil 2015 J Nutr Biochem2015Patil YN, Dille KN, Burk DH, Cortez CC, Gettys TW (2015) Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem 26:1235-47.LEAK
OXPHOS
ET
F
N
S
Gp
ROX
Isolated mitochondriaMouseSkeletal muscle
Liver
Fat
Patil 2024 J Exp Biol2024Patil YN, Gnaiger E, Landry AP, Leno ZJ, Hand SC (2024) OXPHOS capacity is diminished and the phosphorylation system inhibited during diapause in an extremophile, embryos of Artemia franciscana. J Exp Biol 227:jeb.245828. https://doi.org/10.1242/jeb.245828LEAK
OXPHOS
ET
F
N
S
NS
Homogenate
Isolated mitochondria
Artemia
Paulus 2022 Basic Res Cardiol2022Paulus MG, Renner K, Nickel AG, Brochhausen C, Limm K, Zügner E, Baier MJ, Pabel S, Wallner S, Birner C, Luchner A, Magnes C, Oefner PJ, Stark KJ, Wagner S, Maack C, Maier LS, Streckfuss-Bömeke K, Sossalla S, Dietl A (2022) Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. https://doi.org/10.1007/s00395-022-00949-0OXPHOS
ET
NS
F
ROX
Permeabilized tissue
Isolated mitochondria
RabbitHeart
Paumelle 2019 J Hepatol2019Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.OXPHOS
LEAK
F
N
HomogenateHumanLiver
Pedersen 2022 Nat Commun2022Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. https://doi.org/10.1038/s41467-022-30629-5LEAK
OXPHOS
ET
F
N
S
CIV
NS
Permeabilized tissueHumanLiver
Fat
Penniman 2019 Mol Metab2019Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT (2019) Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity. Mol Metab 30:203-220.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Pereira da Silva Grilo da Silva 2018 MiP2018
Filomena Pereira da Silva Grilo da Silva

The unspecific effect of etomoxir on mitochondrial respiration.

OXPHOS
ET
F
N
S
NS
Other combinations
Permeabilized cells
Isolated mitochondria
Human
Mouse
Nervous system
Liver
Other cell lines
Perevoshchikova 2013 Free Radic Biol Med2013Perevoshchikova IV, Quinlan CL, Orr AL, Gerencser AA, Brand MD (2013) Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. Free Radic Biol Med 61:298-309. doi: 10.1016/j.freeradbiomed.2013.04.006LEAK
OXPHOS
ET
F
S
Isolated mitochondriaRatSkeletal muscle
Pereyra 2021 J Lipid Res2021Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM (2021) Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. J Lipid Res 62:100069.LEAK
OXPHOS
F
N
Homogenate
Isolated mitochondria
MouseHeart
Skeletal muscle
Liver
Pereyra 2022 Mol Metab2022Pereyra AS, Lin CT, Sanchez DM, Laskin J, Spangenburg EE, Neufer PD, Fisher-Wellman K, Ellis JM (2022) Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation. https://doi.org/10.1016/j.molmet.2022.101456LEAKF
N
S
Isolated mitochondriaMouseSkeletal muscle
Pereyra 2023 Am J Physiol Gastrointest Liver Physiol2023Pereyra AS, McLaughlin KL, Buddo KA, Ellis JM (2023) Medium-chain fatty acid oxidation is independent of L-carnitine in liver and kidney but not in heart and skeletal muscle. https://doi.org/10.1152/ajpgi.00105.2023LEAK
ROUTINE
OXPHOS
F
N
HomogenateMouseHeart
Skeletal muscle
Liver
Kidney
Permer 2017 Bachelor Thesis2017Permer M (2017) Respirometrische Charakterisierung kryopräservierter HEK 239T Zellen. Bachelor Thesis 1-56.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
HEK
Pesta 2010 MiP AbstractPesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.LEAK
OXPHOS
ET
F
N
S
NS
Human
Pesta 2011 Am J Physiol Regul Integr Comp Physiol2011Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Pesta 2011Abstract Mitochondrial Medicine-TrainingPesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Pesta 2012 Methods Mol Biol2012Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol 810:25-58. https://doi.org/10.1007/978-1-61779-382-0_3LEAK
ROUTINE
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Intact cells
HumanSkeletal muscle
Other cell lines
HEK
Fibroblast
HUVEC
Pesta 2021 Front Endocrinol (Lausanne)2021Pesta D, Jelenik T, Zaharia OP, Bobrov P, Görgens S, Bódis K, Karusheva Y, Krako Jakovljevic N, Lalic NM, Markgraf DF, Burkart V, Müssig K, Knebel B, Kotzka J, Eckel J, Strassburger K, Szendroedi J, Roden M (2021) NDUFB6 polymorphism is associated with physical activity-mediated metabolic changes in type 2 diabetes. https://doi.org/10.3389/fendo.2021.693683LEAK
OXPHOS
ET
F
N
Permeabilized cellsMouseSkeletal muscle
Petrick 2019 Biochem J2019Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58.OXPHOS
LEAK
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Picard 2012 Am J Respir Crit Care Med2012Picard M, Jung B, Liang F, Azuelos I, Hussain S, Goldberg P, Godin R, Danialou G, Chaturvedi R, Rygiel K, Matecki S, Jaber S, Des Rosiers C, Karpati G, Ferri L, Burelle Y, Turnbull DM, Taivassalo T, Petrof BJ (2012) Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation. Am J Respir Crit Care Med 186:1140-9. https://doi.org/10.1164/rccm.201206-0982OCF
Picard 2018 Biol Psychiatry2018Picard M, Prather AA, Puterman E, Cuillerier A, Coccia M, Aschbacher K, Burelle Y, Epel ES (2018) A mitochondrial health index sensitive to mood and caregiving stress. Biol Psychiatry 84:9-17. https://doi.org/10.1016/j.biopsych.2018.01.012FHumanBlood cells
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