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-» A future for Ukraine is the future of its science

2023 Week 45

Nov- 06 Mo

Nov- 07 Tu

How often should I re-assemble the O2k-chamber?

We recommend disassembling, cleaning and re-assembling the O2k-chamber at least every 1-2 years. It is also necessary to disassemble it when there is persistent biological or protein contamination, medium leakage from the chamber, an oxygen leak of the chamber, or an unstable or unexpectedly high or low oxygen signal.
- »O2k-chamber assembly - possible problems« and »O2k-Videosupport: Insert O2k-chamber«
- communicated by »Timon-Gomez Alba« and »Schmitt Sabine«

Nov- 08 We

Nov- 09 Th

Nov- 10 Fr

When should I analyze my data as flux control ratios (FCRs)?

FCRs enable the comparison of samples normalized with various mitochondrial content parameters or when sample concentration is unknown. This is achieved by internally normalizing O₂ fluxes in different respiratory states to the maximum flux in a common reference state.
- »Flux control ratio«
- communicated by »Baglivo Eleonora« and »Timon-Gomez Alba«

Next Week

2023 Week 46

Nov- 13 Mo

Nov- 14 Tu - World Diabetes Day

"Liver [mitochondria] (...) adapt to metabolic challenges by increasing FAO-derived mitochondrial respiration in OBES [obesity model] and NASH [non-alcoholic steatohepatitis model], but by increasing both FAO- and TCA-derived respiration in DIAB [diabetes model]."

Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M (2023) Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. »Bioblast link«

from the O2k-Network »DE Duesseldorf Roden M« and »DE Cologne Pesta D«

Nov- 15 We

Nov- 16 Th - World Pancreatic Cancer Day

"To the advantage of PDAC [pancreatic ductal adenocarcinoma] patients, innovative and more effective therapeutics will be possible with a greater understanding of how pancreatic cancer cells control mitochondrial metabolism."

Padinharayil H, Rai V, George A (2023) Mitochondrial metabolism in pancreatic ductal adenocarcinoma: from mechanism-based perspectives to therapy. »Bioblast link«

Nov- 17 Fr