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Talk:Rogers 2011 PLoS One

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Comments by Erich Gnaiger

This paper describes application of a strongly advertised multi-well system (XF) for respirometry with isolated mitochondria. Whereas multi-well systems do provide high throughput, it must be critically assessed if this is equivalent to high output of useful data and information. Validation is obtained with conventional (low resolution)

Instrumental specifications of the XF multi-well system are missing

Comparison with low-resolution instruments

Low-resolution instruments (compare HRR with Clark-type polarographic oxygen sensors were used, and