Difference between revisions of "Talk:Mitochondrial Diagnostics"
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:::: '''Oroboros Instruments GmbH''' - [https://www.oroboros.at/ www.oroboros.at] | :::: '''Oroboros Instruments GmbH''' - [https://www.oroboros.at/ www.oroboros.at] | ||
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::::* [[Laner V| '''Verena Laner''']] - Oroboros project management | ::::* [[Laner V| '''Verena Laner''']] - Oroboros project management | ||
Revision as of 09:10, 18 October 2022
Talk:Mitochondrial Diagnostics
Mitochondrial Diagnostics
Mitochondrial Diagnostics
- Duration: tbc
- Start: tbc
About Oroboros Diagnostics
- Oroboros Diagnostics builds upon the concept of standardized functional analyses and interpretation of bioenergetic snapshots of (1) cryopreserved PBMCs obtained from minimally invasive blood samples, (2) established cell cultures subjected to pharmacological screening, and (3) mitochondrial preparations obtained from animal or human tissue samples [3,4].
Aims
- Oroboros Diagnostics aims at establishing laboratories for mitochondrial respiratory diagnostics offering bioenergetic snapshots in collaboration with academic and clinical partners, interest groups, funding agencies, and investors.
- Bioenergetic snapshots are obtained from substrate-uncoupler-inhibitor titration protocols in respirometric assays interrogating specific mitochondrial functions [4]. Depending on the diagnostic focus, optimized mitochondrial preparations are applied covering the entire spectrum from living or permeabilized cells to mitochondria isolated from cultured cells or tissues.
References
- Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496.
- Ioannidis JPA, Greenland S, Hlatky MA, Khoury MJ, Macleod MR, Moher D, Schulz KF, Tibshirani R (2014) Increasing value and reducing waste in research design, conduct, and analysis. Lancet 383:166-75.
- Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.8. https://doi.org/10.26124/mitofit:2021-0008
- Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
Coordinator
- Verena Laner - Oroboros project management
Network
Participants
- VASCage GmbH - Research Centre on Vascular Ageing and Stroke: [www.vascage.at www.vascage.at]
- Oroboros Instruments GmbH - www.oroboros.at
- Erich Gnaiger, Ph.D. - PI
- Sabine Schmitt, Ph.D
- Verena Laner - Oroboros project management
- Oroboros Instruments GmbH - www.oroboros.at
Oroboros project involvement
Oroboros Diagnostics Events
Oroboros Diagnostics Publications
Links
News and articles
Support
- This project has received funding from the Austrian Research Promotion Funding Agency (FFG).
- This project has received funding from the Austrian Research Promotion Funding Agency (FFG).
