Revision as of 13:53, 15 June 2015

O2k-Workshop on HRR and O2k-Fluorometry, 2014 October 07-12, Schroecken, Tryol (AT)
O2k-Fluorometry Workshop (advanced), 2014 September 12-16, Obergurgl, Tyrol (AT)
O2k-Basic Workshop 2014 April 07-12, Schroecken, Voralberg (AT)
O2k-Basic Workshop2013 Oct 9-14, Schroecken, Voralberg (AT)
O2k-Fluorometry Workshop2013 Sept 19-23, Obergurgl, Tyrol (AT)
intern: MitoCom Workshop May 16
O2k-Workshop IOC66 O2k-Fluorescence and High-Resolution Respirometry. 2012 March 15 to 16; Innsbruck, Austria. - Feedback

Publications K-Regio MitoCom

International peer-reviewed journals

MiPNet Publications

Abstracts: Invited lectures at international conferences

Abstracts: Poster presentations at international conferences

Exhibitions at international conferences

2014-07-12 to 15: EBEC2014, Lisbon, PT Erich Gnaiger
2014-06-04 to 07: EUROMIT2014, Tampere, FI: Erich Gnaiger, Verena Laner
2014-05-15 to 19: UMDF2014, Pittsburgh, US: Erich Gnaiger, Verena Laner
2014-05-25 to 31: World Congress on High Altitude Medicine and Physiology (ISMM2014), Bolzano, IT: Erich Gnaiger, Verena Laner
2014-01-27 to 30: 38th Mahabaleshwar Seminar, Mahabaleshwar, IN: Erich Gnaiger
2013-12-10 to 11: Exercise in Medicine, Trondheim
2013-12-19 to 21: SMRM2013, Bangalore, India: With an integrated O2k-Workshop IOC83 Erich Gnaiger
2013-11-06 to 07: Mitochondria2013, Tokyo, JP: Erich Gnaiger, Verena Laner
2013-11-04 to 05: ASMRM, Seoul, KR: Invited lectured and luncheon seminar Erich Gnaiger.
2013-09-23 to 27: MiP2013 Obergurgel, Austria. Erich Gnaiger, abstract presentation
2013-06-12 to 15: UMDF2013
2013-02-18: Clinical Hypothermia and Mitochondrial Function Verena Laner, Erich Gnaiger
2013-01-17 to 20: Neurocon 2013, Kolkata, IN: Verena Laner, Erich Gnaiger
2013-01-14 to 16: Pre-conference O2k-Workshop Neurocon 2013, Kolkata, IN: Verena Laner, Erich Gnaiger
2012-12-05 to 10: IOC72 Tutoring Mona Fontana-Ayoub
2012-09-15 to 20: EBEC 2012, Freiburg i. Breisgau, DE: Katrin Stecher, Verena Laner, Erich Gnaiger
2012-05-07: O2k-Fluorometry Mitolab Workshop Madrid: Erich Gnaiger
2012-03-15 to 16: IOC66 - O2k-Fluorescence. An International O2k-Workshop of MitoCom Tyrol.
2011-10-20 to 21: Targeting Mitochondria, Berlin, DE. Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lydia Staudacher.
2011-09-05 to 04: MiP2011 Bordeaux, France. Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lydia Staudacher.
2011-08-31 to 09-04: Kagoshima, Japan. Exhibition of the OROBOROS Oxygraph-2k. Yoshiaki Nakayoshi, Sanyo Trading Co. Ltd., Tokyo, JP and Erich Gnaiger, OROBOROS INSTRUMENTS, AT.
2011-06-15 to 18: UMDF Mitochondrial Medicine 2011 - Chicago, US. Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol. Katrin Stecher, Dominik Pesta, Erich Gnaiger.

Exhibitions and presentations at regional and national events

2012-11-06: MCI Forum Biotechnologie
2012-09-27: Tiroler Standort Lunch in Wien
2012-09-20: Tiroler Medizintechnikforum

International cooperations

Semmelweiss Univ. Budapest, HU

Project meeting with L. Tretter, G. Horvath, A. Nagy, T. Komlodi, V. Laner and E. Gnaiger

Duration: 2014-07-20 to 24

Location: Budapest, Hungary

O2k-Network Lab: HU_Budapest_Tretter_L

Univ. Granada, ES

Carolina Doerrier Velasco was working in the D. Swarovski Research Laboratory between September 19th and December 19th, 2011. The scientific visit aimed at improving her professional skills in the field of high resolution respirometry (HRR) based on her involvement in protocol development of the Network MitoCom Tyrol (www.bioblast/MitoCom).

Zewail City for Science and Technology, ET

Two sudents of Prof. Ali Sameh (O2k-Network Lab: ET_Giza_Ali_SS) were working for two months at the D. Swarovski Lab and focused on their individual projects, learnig high-resolution respirometry.

Islam Abo El Yazeed Kotb (Egypt): Apr 15 to Jun 10,
Abdel Rahman Medhat Khalifa (Egypt): Apr 15 to Jun 10,

see: Visiting_Scientists#April_2013

University of Cambdrige, UK

Xtreme Everst 2 - high-altitude research in Nepal

Dr. Erich Gnaiger and Verena Laner participated at the Xtreme Everest 2 Expedition in Nepal.

Erich Gnaiger (Innsbruck, AT) joined the Xtreme Everest 2 mitochondrial team at Everest Base Camp (5,300 m) where acclimation to high altitude was studied using three O2k (March to May 2013). In Kathmandu (Nepal) at low altitude (1,400 m), Andrew Murray (Cambridge, UK) operated high-resolution respirometry on human musle biopsies with assistance by Verena Laner (Innsbruck, AT).

More infomation: Xtreme Everest 2

Some impressions of the Expedition:

The participants from Innsbruck are supported by the K-Regio project MitoCom Tyrol, D. Swarovski Research Laboratory (Medical University of Innsbruck), and OROBOROS INSTRUMENTS.

MitoCom Track Record 2013

O2k-Workshop, Bangalore, India, Dec 18 prior SMRM2013

IOC83

A one-day O2k-Workshop on HRR and Fluorometry was given by Dr. Erich Gnaiger at the SMRM meeting in Bangalore.

O2k-Fluorometry Workshop, Trondheim, Norway, Dec 10-11

IOC82

Dr. Erich Gnaiger and Verena Laner gave an O2k-Workshop, focused on the Fluorescence LED-2 Module prior the seminar 'Exercise in Medicine', which was organized by CERG of the NTNU University.

O2k-Luncheon Seminar, Seoul, Korea, Nov 05 @ ASMRM2013

IOC81

Dr. Erich Gnaiger (Medical University of Innsbruck) followed the invitation of Prof. Hong Kyu Lee to give a talk at the ASMRM2013 meeting. Furthermore he took this opportunity to give an O2k-Luncheon Workshop on HRR and Fluorometry.

O2k-Fluorometry Workshop, Schroecken, Austria, Oct 09 - 14

IOC80

A new concept, integrating the Flurometry-Workshop into the Basic-O2k-Workshop, was celebrated at the 80th O2k-Workshop in Schroecken. Tutors: Dr. Erich Gnaiger, Mona Fontana-Ayoub, Verena Laner and Gerhard Krumschnabel.

O2k-Fluorometry Workshop, Obergurgl, Austria, September 19-23

IOC79

Prior MiP2013, a O2k-Fluorometry Workshop was given in Obergurgl by Dr. Erich Gnaiger, Dr. Mario Fasching, Mona Fontana-Ayoub and Verena Laner. Hands-on sessions for ~30 participants on 6 O2ks.

O2k-Workshop @ MiPsummer, Copenhagen, DK, August 27-29

IOC78 - Tutors: Dr. Erich Gnaiger and Verena Laner

The workshop is organized by Faculty of Science UK (Doc. M. Kalous and Dr. J. Žurmanová) in cooperation with the Institute of Physiology AVCR (Dr. Z. Drahota and Dr. J. Houštěk) and Medical Faculty UK in Hradec Králové (Prof. Z. Červinková). Dr. Gnaiger was invited on the occasion of We invite you to the occasion of purchasing two new OROBOROS O2k supported bhe the Fund for Universite's Development. The workshop provided an introduction to the Oxygraph-2k and MultiSensor technologies (e.g. the O2k-Fluorescence LED2-Module, which was developped within the K-Regio Project MitoCom Tyrol).

O2k-Workshop, Schroecken, Austria, Apr 09 - 14

IOC75

O2k-TPP-Workshop, Innsbruck, Austria, Jan 22 - 25

IOC74

O2k-Workshop, Kolkata, India, January 15 - 16

IOC73

Dr. Erich Gnaiger - accompanied by Mag. Verena Laner (Oroboros Instruments) - participated at the Neurocon 2013 in Kolkata. Prior the conferece, an O2k-Workshop on high-resolution respirometry and O2k-Fluorometry was held for approx. 30 participants.

MitoCom Track Record 2012

O2k-Workshop, Schroecken, Austria, Dec 5 - 10

IOC72

Bioblast 2012 - Conference on Mitochondrial Competence

The Bioblast Conference 2012 took place in Hotel Grauer Bär from 10^th to 12^th December 2012. With more than 70 participants from 19 nations the conference was a great success.

For the article of the Medical University Innsbruck, see: MUI website

More information: Bioblast 2012

Padua Muscle Days, Nov 23 - 25

After the satellite meeting in Vienna on October 17th, Prof. Dr. Gnaiger was invited by Prof. Dr. Ugo Carraro (University of Padua) to Padua for a talk on high-resolution respirometry in permeabilized fibers from small biopsies of human muscle.

MCI Forum Technologie & Life Sciences, Innsbruck, Nov 6

In her talk, Mag. Verena Laner will outline the development of the company OROBOROS INSTRUMENTS and will walk you through the early company days up to the current K-Regio Project MitoCom Tyrol. Programme

Satellite Meeting Vienna, Oct 17

Dr. Erich Gnaiger participated at the Satellite Meeting in Vienna, which took place on 17th October.

Attendees of this meeting were Delegates of the University in Padua (Univ.-Prof. Dr. Ugo Carraro and Dr. Sandra Zampieri), University in Chieti (Univ.-Prof. Dr. Protasi) and University in Rome (Univ.-Prof. Dr. Andrea Musaro).

The meeting was organized by Dr. Kern from the Ludwig Boltzmann Institute in Vienna.

Standort Lunch Vienna, 2012 Sep 27

Dr. Erich Gnaiger presented the MitoCom project at the Standort Lunch in Vienna, organized by the Standortagentur Tirol. More information.

The article of the STANDORT Tirol you can find in issue no. 15, page 8

Medizintechnikforum Hall, 2012 Sep 20 to 21

OROBOROS INSTRUMENTS exhibited at the Medizintechnikforum Hall, showing latest developments in high-resolution respirometry in combination with the O2k-Fluorescence LED2-Module. MitoCom Tyrol was presented together with the Open Innovation project, both supported by the Government of Tyrol.

Tiroltag, Europäisches Forum Alpbach, 2012 Aug 19

Verena Laner, the project manager of MitoCom Tyrol, took part at the Tirolday, which was the "Opening" of the European Congress in Alpbach 2012. The main topic was "The future of sports in the Alps", which is an integral part of the MitoCom project. Additionally to the presentations and the award presentation ceremony for young scientists, there was a podium discussion with well-known experts such as the famous alpinist Reinhard Messner.

MitoCom Cooperation AltitudeOmics 2012, 2012 July 20 to Aug 13

Dr. Erich Gnaiger participated in the AltitudeOmics2012 project in Bolivia and provided the scientists with two O2ks and his expertise. Aim of the study was to investigate the impacts of hypoxia/acclimatization onto molecular mechanisms of the human cells.

Visiting scientist: Prof. Dr. Fr. Baby Joseph, July 19

On July 19th, Prof. Dr. Fr. Baby Joseph visited the OROBOROS office.

Time schedule of the research visit

Houska Award 2011 - First price for MitoCom Tyrol, April 26

First price - Medical University of Innsbruck: http://www.oroboros.at/?Houska-Award_2011
http://www.houskapreis.at/siegerprojekt-2011-licht-in-die-kraftwerke-der-zellen
http://www.houskapreis.at
http://www.tt.com/Nachrichten/4702341-6/houska-preise-an-universit%C3%A4ten-in-innsbruck-und-graz.csp

Mitolab O2k-Fluorometry Workshop Madrid, Spain, May 7

Mitolab Workshop by Erich Gnaiger
Contact: Eduardo Rial (Email: [email protected]) and Susana Cadenas (Email: [email protected])

>> See also MitoCom_Tyrol - Report

O2k-Workshop Schröcken, Austria, April 11 to 16

IOC68

O2k-Workshop Sydney, Australia, April 2 to 4

IOC67 - an International O2k-Workshop of MitoCom Tyrol.

First O2k-Fluorometry Workshop, Innsbruck, March 15 to 16

IOC66 O2k-Fluorometry Workshop. An International O2k-Workshop of MitoCom Tyrol.

Manuscript accepted for publication in PloS One, March 9

"Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle" (by Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D) was accepted for publication in PloS One.
From the anonymous referee's comments:
- Reviewer #1: "This is an original work performed with state of the art methodologies, as high-resolution respirometry. The results indicate that not only mitochondrial capacity is a limiting factor of horse performance but also the modalities of energy substrate utilization. Horse is an animal of choice for energetic studies since it shows a huge consumption of oxygen during muscle contraction, suggesting an positive adaptation of the mitochondrial system as compared to other animals. .. This article provides new findings on the link between mitochondrial capacity and whole animal body size and aerobic capacity. It also clarifies whether mitochondrial capacity is a controling factor for horse performance. An important finding is also that the control by the phosphorylation system is stable and does not vary with the performance of the horse. In contrast, the relative utilization of complex I versus complex II varies witht he performance, and this is a new finding which adds up to our knowledge of energy regulation. This work is of broad interest for sport physiology, metabolic researchers and aging research."
- Reviewer #2: "The results could be described in a much easier way if utilizing classical definitions of mitochondrial respiratory parameters (from the late Britton Chance's milestones), such as state IV (or II), state III, uncoupled respiration, respiratory control ratio and so on." (Comment: MitoPedia: Respiratory states)

MitoCom track record 2011

2011-12-10 to 15: Internatl. O2k-Workshop on High-Resolution Respirometry, Schröcken, Austria

2011-12-08: O2k-Workshop on High-Resolution Respirometry, Hyderabad, India

See also: Science Calendar

2011-11-29: 9. Tiroler Innovationstag

13:00-14:30 Cluster-Partnertreffen LIFE SCIENCES Tirol

Programm

ab 12.30 Uhr: Treffen im Congress Innsbruck, 3. Stock

13.00 Uhr: Begrüßung DDr. Petra Stöckl (Programm Managerin Life Sciences Tirol)

13.05 Uhr: Die neue Clusterstrategie. Vorstellung der Eckdaten

13.20 Uhr: Vorstellung der Clusterpartner und Diskussion der Clusterstrategie

14.15 Uhr Vorstellung K-Regio MitoCom. Univ.-Prof. Dr. Erich Gnaiger (Oroboros)

15:00 m Tiroler Innovationstag - Programm

2011-11-19: An extension of Bioblast

In addition to the MitoPedia: Respirometry, the MitoPedia: Fluorometry and MitoPedia: Spectrophotometry were initiated by David Harrison.

2011-11-11: Bioblast alert

Bioblast alert was launched, for information purposes, not intended to be an advertisement.

2011-11-04: Product news

O2k-Fluorescence LED2-Module

2011-November: MitoCom Lectures, Innsbruck

Introduction to mitochondrial respiratory physiology

2011-10-20 to 21: Targeting Mitochondria, Berlin, DE

Invited lecture: Erich Gnaiger - Gnaiger 2011 Abstract-Berlin
Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lyda Staudacher

2011-09-24: High-output to replace wasteful high-throughput?

Discussion: OROBOROS O2k versus Seahorse XF

2011-09-05 to 04: MiP2011 Bordeaux, France

8th Conference on Mitochondrial Physiology - MiP2011. Bordeaux, France.
Invited lecture: Erich Gnaiger - Sumbalova 2011 Abstract Bordeaux
Poster: Erich Gnaiger - Lemieux_2011_Abstract Bordeaux
Poster: Mario Fasching - Fasching_2011_Abstract Bordeaux
Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Lyda Staudacher

2011-08-31 to 09-04: KAGOSHIMA JAPAN

5th Biennial Meeting of Society for Free Radical Research (SFRR)-Asia, 8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM), and 11th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit); Kagoshima Citizens´Culture Hall, Kagoshima, Japan. Chair: Prof. Hideyuki J. Majima; E-mail: [email protected]
Invited lecture: Erich Gnaiger - Sumbalova 2011 Abstract Kagoshima
Exhibition of the OROBOROS Oxygraph-2k: Yoshiaki Nakayoshi, Sanyo Trading Co. Ltd., Tokyo, JP

2011-08-26 to 27: O2k-Workshop China

O2k-Workshop on High-Resolution Respirometry, Beijing and Tianjin, China

2011-08-12: Circular on MitoScore

MitoScore is an initiative of MitoCom:

File:Network MitoScore.pdf

2011-08-09: Manuscript accepted for publication in IJBCB

"Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart" (by Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E) was accepted for publication in Intl. J. Biochem. Cell Biol.
From the anonymous referee's comments:
- Reviewer #1: "The manuscript by Lemieux and colleagues offers interesting insight into the bioenergetics of early phases of heart failure."
- Reviewer #2: "This is a beautifully written work, replete with well-designed experiments and, within the space limitations, a nice review of the pertinent literature. The demonstration of impaired mitochondrial fatty acid oxidation in early stages of human failure is very important, as is the demonstration of defects in the phosphorylation system and Complex I-linked respiration."
- Reviewer #3: "The manuscript belongs literally to the symphony of bioenergetics and have mastered on a maximum thorough and detailed level a priority study of human heart disease bioenergetics in an intermediate state of heart disease, which was done only scarcely in medical sciences and for this orthodox approach this work deserves a high attention. It elegantly describes detailed oxidative phosphorylation parameters in heart disease compared to the control human heart. Using high-resolution respirometry of permeabilized human heart muscle fibres authors progressively describe distinct aspect of measured data in logical steps to present important differences of diminished mitochondrial function during heart failure. Using elegant protocols developed for years, authors distinguish between phosphorylating (OXPHOS) and non-phosphorylating (ETS) conditions with both complex I and II input using physiological substrates of glucose and lipid oxidation. With presented protocols, authors are able to provide conclusions regarding, e.g., complex I impairment, phosphorylation system limitation (3.2) mitochondrial content (3.3), leak respiration involvement, etc., besides OXPHOS and ETS capacities. Authors use their own terminology describing respiratory states. It would be useful to explain briefly their terminology also in terms of the canonical state 2 - 4 terminology. In spite of this, the methodology approach and presented data are well explained."

2011-07-18: Informal MitoCom-MiPArt 18:18

Monday, July 18 ● 18:18 h ● Schöpfstr. 18 – we thank our guests for sharing a friendly 18:18 evening with us.
- Informal get-together at 'Oroboros' - science and art - celebrate a "beautifully written work" - a "symphony of bioenergetics" (see 2011-08-09).
- Celebrate the official acceptance of K-Regio MitoCom Tyrol.
- Explore future perspectives.

2011-07-12: The K-Regio MitoCom project - accepted

The project application MitoCom Tyrol was officially accepted.

2011-07-12: Manuscript accepted in AJP

"Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans" by Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E, was accepted for publication in Am. J. Physiol. Regul. Integr. Comp. Physiol. (http://www.ncbi.nlm.nih.gov/pubmed/21775647).
From the anonymous referee's comments: This is really a superb revision; the MS has been improved substantially, particularly with reference to the theory and methods re: the HRR.

2011-07-11 to 13: Introductory O2k-Workshop (IOC62) - MitoCom Tyrol

Location: OROBOROS INSTRUMENTS, Schöpfstr. 18, Innsbruck, Austria.
More informatio: IOC62

2011-06-15 to 18: UMDF Mitochondrial Medicine 2011 - Chicago, US

Poster: Erich Gnaiger - Burtscher 2011 AbstractUMDFChicago
Poster: Dominik Pesta - Pesta_2011_AbstractUMDFChicago-Training
Poster: Dominik Pesta - Pesta_2011_AbstractUMDFChicago-Diagnosis
Exhibition of OROBOROS INSTRUMENTS and MitoCom Tyrol: Katrin Stecher, Dominik Pesta, Erich Gnaiger

2011-05-18: MiPArt - Mitochondria - the Aliens in our Cells

MiPArt - Mitochondria - the Aliens in our Cells

Exhibition (Odra Noel, Richard Altmann and others)
Presentation of MitoCom Tyrol

2011-05-01: Start K-Regio Project MitoCom Tyrol

Workshops towards MitoCom 1

» Archive K-Regio MitoCom 1

Management

2011-10-30: ORO installed an 'Intern wiki' for communication, documentation and organization of the K-Regio Project MitoCom.

@@ Line 118: / Line 118: @@
 ::*[[Pesta_2011_AbstractUMDFChicago-Diagnosis|Pesta D, Wiethuechter A, Karall D, Schocke M, Gnaiger E (2011) Functional mitochondrial diagnosis in a patient suffering from sudden exercise intolerance. Abstract Mitochondrial Medicine Chicago]].
 ::*[[Pesta 2011 AbstractUMDFChicago-Training|Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibres. Abstract Mitochondrial Medicine Chicago, USA]].
-::*[[Sumbalova 2011 Abstract Mitochondrial Medicine Chicago|Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.]]
+::*[[Sumbalova_2011Abstract_Mitochondrial_Medicine|Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.]]
 ::*[[Burtscher 2011 AbstractUMDFChicago|Burtscher M, Dietrich H, Gatterer H, Gnaiger E, Harrison DK, Karall D, Krismer M, Lass-Floerl C, Parson W, Perkhofer S, Pesta D, Schocke M, Sumbalova Z, Wiethüchter A (2011) Mitochondrial competence. Regional and international cooperation for establishing new standards in functional mitochondrial diagnosis. Abstract Mitochondrial Medicine Chicago, USA]].

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