Substrate control: Difference between revisions
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|abbr=n.a. | |abbr=n.a. | ||
|description=Substrate control with electron entry separately through [[Complex I]] (pyruvate | |description=Substrate control with electron entry separately through [[Complex I]] (pyruvate&malate or glutamate&malate) or [[Complex II]] (succinate, rotenone) restricts [[ETS capacity]] and artificially enhances flux control upstream of the Q-cycle, providing diagnostic information on specific branches of the ETS. Physiological combinations of Complex I<small>&</small>II substrates support maximum ETS and [[OXPHOS capacity |OXPHOS capacities]], due to the additive effect of multiple electron supply pathways converging at the [[Q-junction]]. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
|type=Respiration | |type=Respiration | ||
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{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Respiratory state | |mitopedia topic=Respiratory state | ||
|type=Respiration | |type=Respiration | ||
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Revision as of 01:39, 10 March 2015
- high-resolution terminology - matching measurements at high-resolution
Substrate control
Description
Substrate control with electron entry separately through Complex I (pyruvate&malate or glutamate&malate) or Complex II (succinate, rotenone) restricts ETS capacity and artificially enhances flux control upstream of the Q-cycle, providing diagnostic information on specific branches of the ETS. Physiological combinations of Complex I&II substrates support maximum ETS and OXPHOS capacities, due to the additive effect of multiple electron supply pathways converging at the Q-junction.
Abbreviation: n.a.
Reference: Gnaiger 2014 MitoPathways
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
