Search results

P-L net OXPHOS capacity
...EAK component of respiration, ''LP'', as measured in the OXPHOS state, particularly if the protonmotive force is not adjusted to equivalent level ::::* Expand Bioblast links to '''''P-L'' net OXPHOS capacity'''

1 KB (190 words) - 01:27, 31 December 2020
PalOctPM
'''MitoPathway control state:''' [[FN]] |mitopedia concept=SUIT state

789 bytes (94 words) - 14:36, 26 August 2020
PalOctPGMS
'''MitoPathway control state:''' [[FNS]] |mitopedia concept=SUIT state

852 bytes (97 words) - 14:36, 26 August 2020
PalOctPGM
'''MitoPathway control state:''' [[FN]] |mitopedia concept=SUIT state

829 bytes (96 words) - 14:36, 26 August 2020
PalOctM
'''MitoPathway control state:''' [[ F | Fatty acid oxidation pathway control state]] |mitopedia concept=SUIT state

737 bytes (94 words) - 17:11, 22 January 2019
PalM
'''MitoPathway control state:''' [[ F | Fatty acid oxidation pathway control state]] |mitopedia concept=SUIT state

715 bytes (94 words) - 17:07, 22 January 2019
PGMSGp pathway control state
'''MitoPathway control state:''' NSGp OctPGMSGp pathway in the OXPHOS state can be evaluated in the following SUIT protocols:

1 KB (131 words) - 14:12, 12 April 2023
PalPGMSGp pathway control state
'''MitoPathway control state:''' FNSGp OctPGMSGp pathway in the OXPHOS state can be evaluated in the following SUIT protocols:

1 KB (129 words) - 14:11, 12 April 2023
OctPGM pathway control state
'''MitoPathway control state:''' [[FN]] ...e is added to compare FAO as the background state with FN as the reference state.

2 KB (241 words) - 05:00, 19 July 2022
OctPM pathway control state
'''MitoPathway control state:''' [[FN]] ...e is added to compare FAO as the background state with FN as the reference state.

2 KB (251 words) - 04:59, 19 July 2022
O2k-Publications: OXPHOS
::: '''[[Coupling-control state]]''' :::: [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|link=ET ca

2 KB (228 words) - 15:41, 8 June 2020
Malate-anaplerotic pathway control state
...substrate combinations ([[PM-pathway control state]], [[GM-pathway control state]]). ...alate-anaplerotic pathway (malate alone in the presence of ADP) and OXPHOS state (''P'') with pyruvate&malate and pyruvate&glutamate&malate as NADH-linked s

2 KB (283 words) - 01:28, 31 December 2020
Coupled respiration
...corresponding coupled respiration is the [[free OXPHOS capacity]]. In the state of ROUTINE respiration, coupled respiration is the [[free ROUTINE activity]

1 KB (138 words) - 19:40, 1 January 2021
OctGMS
'''MitoPathway control state:''' [[FNS]] OctGMS pathway in the LEAK state can be evaluated in the following SUIT protocols:

935 bytes (113 words) - 04:53, 19 July 2022
OctGM
'''MitoPathway control state:''' [[FN]] ::::» [[OctPGM pathway control state]]

1 KB (142 words) - 04:55, 19 July 2022
State 3
...ate]] of respiration, whereas the cytochromes are in a more oxidized redox state. |mitopedia concept=Respiratory state, Find

3 KB (449 words) - 18:46, 1 January 2021
Hyphenation
...nt), but if the compound adjective follows the term (measurement at steady state), hyphenation does not add any information and should be avoided. Find more ...ate]] (''NOT'' 'Coupling control state' - it is not 'coupling of a control state')

4 KB (469 words) - 02:31, 23 January 2023
OctPMS
'''MitoPathway control state:''' [[FNS]] ::::» [[OctPGM pathway control state]]

1 KB (133 words) - 04:53, 19 July 2022
Baris 2015 Am J Physiol Regul Integr Comp Physiol
...eratures. Closer examination of the data also suggests that differences in State 3 respiration and Complex I activity between populations were greatest betw |keywords=Fundulus, State 3, Enzyme complexes, Mitochondria

2 KB (340 words) - 16:52, 9 November 2017
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum
...bility for this animal model to use palmitoylcarnitine or a very high LEAK state (or both!) #LEAK state was recorded

1 KB (222 words) - 15:57, 7 November 2016
State 3u
...an uncoupled contribution; State 3) and noncoupled [[ET capacity]] (''E''; State 3u) ([[Gnaiger 2009 Int J Biochem Cell Biol|Gnaiger 2009]]; [[Rasmussen 200 == Why not 'State 3u'? ==

1 KB (140 words) - 01:19, 31 December 2020
Coupling-control ratio
...is defined by taking ''Z'' as the maximum flux, i.e. flux ''E'' in the ET-state, such that the lower and upper limits of the ''CCR'' are defined as 0.0 and

2 KB (223 words) - 18:57, 7 February 2021
Harmonization
...ROUTINE respiration]], in ROUTINE state || [[basal respiration]], in basal state | ''P'' || [[OXPHOS capacity]], in OXPHOS state of mt-preparations || [[State 3]]

2 KB (263 words) - 14:27, 19 October 2022
SUIT-025
|abbr=OXPHOS (F+M+P+G+S+Rot) ...ion_pathway_control_state|F]], F(N), [[FN]] and [[FNS]] pathways in OXPHOS state can be evaluated by using this SUIT protocol.

3 KB (407 words) - 13:24, 5 June 2019
OctPGMSGp pathway control state
'''MitoPathway control state:''' FNSGp OctPGMSGp pathway in the OXPHOS state can be evaluated in the following SUIT protocols:

1 KB (176 words) - 05:02, 19 July 2022
NSGp
'''MitoPathway control state:''' NSGp NSGp pathway in the LEAK state can be evaluated in the following SUIT protocols:

1 KB (156 words) - 14:03, 12 April 2023
Respiratory state
...f both, the [[coupling-control state]] and the [[electron-transfer-pathway state]]. [[Image:P.jpg|right|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|right|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|righ

3 KB (400 words) - 15:50, 15 August 2021
SUIT-039 O2 mt D092
...er electron transfer pathways are also analyzed in OXPHOS (FN, FNS) and ET-state (FNS, S). :::+ The protocol provides information on F-pathway in OXPHOS state with palmitoylcarnitine, a long-chain acylcarnitine commonly found ''in viv

3 KB (387 words) - 11:21, 14 April 2023
SUIT-039 O2 pfi D093
...er electron transfer pathways are also analyzed in OXPHOS (FN, FNS) and ET-state (FNS, S). :::+ The protocol provides information on F-pathway in OXPHOS state with palmitoylcarnitine, a long-chain acylcarnitine commonly found ''in viv

3 KB (387 words) - 12:30, 14 April 2023
SUIT-003 Ce1;ce2SD;ce3U;ce4Rot;ce5Ama
! Respiratory state ...f respiration. Mitochondria of dead cells (dce) without substrate are in a state of ROX.

1 KB (216 words) - 09:44, 3 June 2020
SUIT-040 O2 mt D094
...tron transfer pathways are also analyzed in OXPHOS (FN, FNS, FNSGp) and ET-state (FNSGp, SGp). :::+ The protocol provides information on F-pathway in OXPHOS state with palmitoylcarnitine, a long-chain acylcarnitine commonly found ''in viv

3 KB (388 words) - 12:30, 14 April 2023
SUIT-040 O2 pfi D095
...tron transfer pathways are also analyzed in OXPHOS (FN, FNS, FNSGp) and ET-state (FNSGp, SGp). :::+ The protocol provides information on F-pathway in OXPHOS state with palmitoylcarnitine, a long-chain acylcarnitine commonly found ''in viv

3 KB (388 words) - 11:21, 14 April 2023
OctM pathway control state
'''MitoPathway control state:''' F ::::» [[Fatty acid oxidation pathway control state]]

1 KB (161 words) - 04:56, 19 July 2022
Glutamate-anaplerotic pathway control state
...as the sole fuel substrate in the '''glutamate-anaplerotic pathway control state''', G is transported by the electroneutral glutamate-/OH- exchanger, and is LEAK state (''L'') with G alone as substrate can be evaluated in the following SUIT pr

2 KB (276 words) - 20:11, 1 January 2021
GMS-pathway control state
...xoglutarate, which then establishes a cycle without generation of citrate. OXPHOS is higher with GS (CI&II) compared to GM (CI) or SRot (CII). This documents ::::» [[OctPGMSGp pathway control state]]

3 KB (378 words) - 18:30, 17 March 2022
Oxidative phosphorylation
|abbr=OXPHOS ...nt of respiration. The OXPHOS state of respiration provides a measure of [[OXPHOS capacity]] (''P''), which is frequently corrected for [[residual oxygen con

3 KB (334 words) - 09:05, 27 May 2022
Liemburg-Apers 2015 Biophys J
...Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux. Biophys J 109:1372-86. ...aken together, we demonstrate here that OXPHOS inhibition increases steady-state GLC uptake and consumption in C2C12 myoblasts. This activation fully compen

3 KB (358 words) - 14:34, 27 March 2018
SUIT-015
...ration#The_LEAK_state |LEAK state]] and [[Oxidative phosphorylation|OXPHOS state]]''' ...osphorylation|OXPHOS state]] and of [[FNS]] and [[S]] in [[ET capacity| ET state]] can be evaluated. SUIT-015 can be extended with the CIV assay module.

3 KB (393 words) - 15:21, 8 June 2020
SUIT-025 O2 mt D057
:::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.

2 KB (345 words) - 10:29, 18 September 2020
Pathway control ratio
...OS]], [[Electron transfer pathway]]), numerous [[Electron-transfer-pathway state]]s are possible. ...h variable [[N]]-linked injuries are studied. In contrast, the [[reference state]], ''Z'', is strictly defined for [[flux control efficiency]].

1 KB (206 words) - 12:20, 25 November 2020
GM-pathway control state
'''MitoPathway control state:''' [[NADH electron transfer-pathway state]] The '''GM-pathway control state''' (glutamate-malate pathway control state) is established when glutamate&malate are added to isolated mitochondria, p

2 KB (249 words) - 15:32, 2 August 2023
SUIT-027
|abbr= [[Malate-anaplerotic pathway control state|Malate anaplerosis]] |info='''A:''' '''[[Malate-anaplerotic pathway control state|Malate anaplerotic pathway]]'''

3 KB (429 words) - 12:04, 3 June 2020
SUIT-021 O2 mt D035
:::* NS-OXPHOS capacity provides a physiologically relevant estimate of maximum mitochondr ...tate| S]] and [[NADH Electron transfer-pathway state| N-]] pathway control state.

3 KB (420 words) - 09:20, 18 September 2020
Doerrier 2022 MitoFit NADH
...ous measurement of oxygen consumption and NAD(P)H/NAD(P)+-redox state in isolated mitochondria. (in prep) |keywords=NADH fluorescence, NAD-pool, N-junction, NAD-redox state, high-resolution respirometry HRR, isolated mitochondria, mouse liver mitoc

946 bytes (114 words) - 10:06, 3 May 2022
Du 2015 Aquat Toxicol
...exposure and undosed fish show decreased LEAK and increased State 3 and E state. |couplingstates=LEAK, OXPHOS, ET

2 KB (339 words) - 17:51, 9 November 2017
SUIT-019
...rylation|OXPHOS state]], and [[FN]]—[[FNS]]—[[S]] in the [[ET capacity| ET state]]. :::* SUIT-019 allows the study of OXPHOS capacity in the fatty acid oxidation (F) and fatty acid oxidation&NADH path

3 KB (412 words) - 12:33, 25 November 2020
Lim 2018 Sci Rep
...n in steady-state OXPHOS complex levels, resulting in secondary defects in OXPHOS function which may contribute to the pathology of MCAD deficiency.

2 KB (307 words) - 12:13, 25 June 2019
SUIT-005
|info='''A:''' when [[Malate-anaplerotic pathway control state |malate-anaplerotic activity]] is zero ...provides a physiologically relevant estimate of maximum [[OXPHOS capacity| OXPHOS-]] and [[ET capacity |ET capacity]]. SUIT-005 can be extended with the CIV

3 KB (424 words) - 14:30, 10 March 2023
SUIT-037 O2 mt D090
:::: 4. to analyse OXPHOS respiration and ET-capacity with various pathways (F, N, S, Gp) :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d

3 KB (485 words) - 11:21, 14 April 2023
PGMS-pathway control state
'''MitoPathway control state:''' [[NS|NS-pathway control state]] ::::» [[NS-pathway control state]]

2 KB (284 words) - 18:29, 17 March 2022
Gnaiger 2018 AussieMit
...ia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU. ...moxia) is far lower than ''in-vitro'' air-level normoxia. We show that the OXPHOS-LEAK-ROS paradigm cannot be extended to physiological tissue normoxia.

3 KB (478 words) - 19:03, 10 January 2022
Respiratory acceptor control ratio
...living cells, the term ''RCR'' has been used for the ratio [[State 3u]]/[[State 4o]], i.e. for the inverse ''[[L/E]]'' ratio [2,3]. Then for conceptual and ...(2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. BEC 2020.2. - [[Gnaiger 2020 BEC MitoPathways |»Bioblast

3 KB (391 words) - 13:31, 29 May 2022
FNSGp
'''MitoPathway control state:''' FNSGp ::::» [[OctPGMSGp pathway control state]]

2 KB (207 words) - 04:54, 19 July 2022
Level flow
|description=[[File:E.jpg |link=ET capacity]] '''Level flow''' is a [[steady state]] of a system with an input process coupled to an output process (coupled s == Level flow and State 3 ==

2 KB (307 words) - 15:00, 8 June 2020
O2k-Publications: LEAK
::: '''[[Coupling-control state]]''' :::: [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|link=ET ca

2 KB (227 words) - 15:41, 8 June 2020
O2k-Publications: ROUTINE
::: '''[[Coupling-control state]]''' :::: [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|link=ET ca

2 KB (227 words) - 15:41, 8 June 2020
SUIT-019 O2 pfi D045
:::*SUIT-019 provides an estimation of F OXPHOS capacity, physiologically relevant estimate of maximal Complex I capacity a ...of other, potentially interfering pathways, both in the LEAK state and in OXPHOS.

3 KB (424 words) - 14:38, 17 September 2020
PMS-pathway control state
::::» [[NS-pathway control state]] PMS pathway in the LEAK state can be evaluated in the following SUIT protocols:

1 KB (193 words) - 18:30, 17 March 2022
SUIT-036 O2 mt D089
:::: 4. to analyse OXPHOS respiration and ET-capacity with various pathways (F, N, S, Gp) :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d

3 KB (450 words) - 11:20, 14 April 2023
E-P excess capacity
...the capacity of the [[phosphorylation system]] exerts a limiting effect on OXPHOS capacity. In addition, ''E-P'' depends on coupling efficiency, since ''P'' |mitopedia concept=Respiratory state, Recommended

774 bytes (96 words) - 01:33, 31 December 2020
O2k-Publications: ET
::: '''[[Coupling-control state]]''' :::: [[Image:P.jpg|link=OXPHOS capacity|OXPHOS]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] [[Image:E.jpg|link=ET ca

2 KB (227 words) - 15:41, 8 June 2020
OctPGMS pathway control state
'''MitoPathway control state:''' [[FNS]] ::::» [[OctPGM pathway control state]]

2 KB (209 words) - 05:01, 19 July 2022
OXPHOS capacity
...rations of [[ADP]] and inorganic phosphate (which may not be the case in [[State 3]]), oxygen, and defined reduced CHNO-fuel substrates. ...possible in mt-preparations supported by an ET-pathway competent substrate state, exemplifed as the NS-pathway (CI&II-linked substrate supply

6 KB (808 words) - 01:02, 31 December 2020
St-Pierre 2000 Am J Physiol Regul Integr Comp Physiol
...ergence and was accompanied by 1) a reduction in mitochondrial state 4 and state 3 rates and 2) an increase in the O2 affinity of mitochondria. T |keywords=Frog, Hypoxia, State 3, State 4, P50

2 KB (264 words) - 09:30, 9 November 2016
E-P control efficiency
...'' = 1 at the limit of zero phosphorylation capacity. The [[OXPHOS]] state of mt-preparations is stimulated to [[electron transfer pathway]] capacity == List of publications: OXPHOS and ET pathway ==

2 KB (288 words) - 18:29, 1 January 2021
Komlodi 2018 AussieMit
...O2 flux, H2O2 flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU. ...an altered Q redox state. We analyzed the relationship between the Q redox state, H2O2 and O2 fluxes with fuel substrates p

3 KB (517 words) - 18:56, 10 January 2022
Coupling-control state
...ling-control states sequentially at a constant [[electron-transfer-pathway state]]. '''Coupling-control states:''' [[Image:P.jpg|link=OXPHOS capacity|OXPHOS capacity]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE respiration]] [[I

2 KB (293 words) - 18:58, 7 February 2021
SUIT-041 O2 mt D096
:::+ The protocol provides information on F-pathway in OXPHOS state with multiple titrations of acylcarnitines (e.g., octanoylcarnitine, palmit :::+ F-pathway (3Pal-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.

3 KB (391 words) - 11:21, 14 April 2023
Kuhnt 2007 Neurochem Res
...nt T, Pelz T, Qu X, Haensgen G, Dunst J, Gellerich FN (2007) Mitochondrial OXPHOS functions in R1H rhabdomyosarcoma and skeletal muscles of the rat. Neuroche ...g/min versus 2.32 ± 1.19 nmol O2/mg/min, P < 0.001, whereas the State 3 respiration of succinate + rotenone was increased: 36 ± 14% versus 19 ±

2 KB (259 words) - 10:57, 27 March 2018
State 2
...ubsequently oxygen flux declines to a low level (or zero) at the steady '''State 2''' ([[Chance_1955_JBC-III|Chance and Williams 1955]]). ADP concentration |mitopedia concept=Respiratory state, Find

3 KB (334 words) - 18:45, 1 January 2021
SGp-pathway control state
'''MitoPathway control state:''' SGp; obtained with OctPGMSGp(Rot) This pathway control state is obtained in the presence of CI-linked and FAO-linked substrates after in

2 KB (257 words) - 05:01, 19 July 2022
SUIT-020 O2 mt D032
...f the ATP synthase. Since higher concentrations of Omy can decrease the ET state induced upon addition of uncoupler, the required concentration of Omy has t :::* NS-OXPHOS capacity provides a physiologically relevant estimate of maximum mitochondr

4 KB (636 words) - 15:11, 17 September 2020
N/S pathway control ratio
...s. The S-pathway control state may be selected preferentially as reference state, if mitochondria are studied with respect to N-pathway injuries. ...in the OXPHOS-state, but N''E''/S''E'' ~ 2 in the ET-state (high [[E-P excess capacity |''E-P'' excess capacity]] specifically for the

2 KB (300 words) - 19:14, 30 December 2020
SUIT-016
...ration#The_LEAK_state |LEAK state]] and [[Oxidative phosphorylation|OXPHOS state]]''' ...] in [[LEAK respiration#The_LEAK_state |LEAK state]] and [[ET capacity| ET state]] is evaluated.

4 KB (543 words) - 15:19, 8 June 2020
Towheed Atif
|state=Pennsylvania (PA) ...netics, Mitochondrial encephalomyopathies, Drosophila, ATP6, ATP synthase, OXPHOS

510 bytes (59 words) - 13:50, 17 March 2020
Aerobic
...reactions (ox) to proceed, particularly in [[oxidative phosphorylation]] (OXPHOS). Aerobic metabolism (with involvement of oxygen) is contrasted with [[anae {{Template:Normoxia - state or rate}}

993 bytes (124 words) - 14:30, 21 October 2021
NADH electron transfer-pathway state
...alonic acid]]). In the N-pathway control state [[Electron-transfer-pathway state|ET pathway level 4]] is active. |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]]

3 KB (409 words) - 08:06, 25 November 2023
SUIT-007
|abbr=[[Glutamate-anaplerotic pathway control state|Glutamate anaplerosis]] |info='''A:''' '''[[Glutamate-anaplerotic pathway control state|Glutamate anaplerotic pathway]]'''

3 KB (401 words) - 11:30, 3 June 2020
MitoPedia: Respiratory states
:::: [[Image:P.jpg|link=OXPHOS capacity|OXPHOS capacity]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE-respiration]] [[I :::: [[Image:P-L.jpg|50 px|link=P-L net OXPHOS capacity|''P-L'' net OXPHOS capacity]] [[Image:R-L.jpg|50 px|link=R-L net ROUTINE capacity|''R-L'' net

2 KB (243 words) - 08:37, 25 November 2023
Mitchell 1969 Eur J Biochem
...etermined in State 5 and the change of these values in the transition from State 5 to States 4 and 3. |couplingstates=OXPHOS

3 KB (410 words) - 12:16, 28 May 2015
McMaster 2018 Am J Obstet Gynecol
determined by Western blot with OxPhos, an antibody cocktail rates measured include: basal state (no substrates), state 2

3 KB (360 words) - 10:24, 8 January 2018
Chowdhury 2000 Clin Chim Acta
...ermine the mitochondrial membrane potential under steady-state conditions (state 4 with succinate). These protocols are presented together with reference co |couplingstates=LEAK, ROUTINE, OXPHOS

2 KB (261 words) - 19:08, 1 April 2018
Sumbalova 2011 Abstract Kagoshima
...ion, but CI+II electron supply increased JH2O2 further in the passive LEAK state of respiration. The upper limit of respiratory capacity and the scope of RO |keywords=High-resolution respirometry, OXPHOS, mitochondrial membrane potential, ROS production, brain mitochondria, O2k-

3 KB (457 words) - 18:18, 10 January 2022
Harrison 2014 Abstract MiP2014
|title=The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during ...cessfully described the measured relationship between cytochrome oxidation state and oxygen consumption.

3 KB (363 words) - 22:47, 14 November 2022
Duicu 2012 Rev Med Chir Soc Med Nat Iasi
...ansport system (ET-pathway); CII_P, 302.26 +/- 50.16 (CII dependent OXPHOS state obtained after the addition of a CI inhibitor rotenone, with the subsequent |couplingstates=LEAK, OXPHOS, ET

2 KB (325 words) - 11:42, 23 January 2019
PGM-pathway control state
'''MitoPathway control state:''' [[NADH electron transfer-pathway state]] ...-oxoglutarate]]), representing the [[glutamate-anaplerotic pathway control state]]. 2-oxoglutarate (α-ketoglutarate) is formed from isocitrate (isocitrate

3 KB (316 words) - 13:14, 2 August 2023
Christiansen 2015 Am J Physiol Heart Circ Physiol
...physiology of HCM and support the hypothesis that restoration of the redox-state in the mitochondria is beneficial in the treatment of HCM. |couplingstates=LEAK, OXPHOS, ET

3 KB (373 words) - 17:34, 25 February 2020
NS-pathway control state
...rations by addition of [[NADH]]-generating substrates ([[N-pathway control state]] in combination with [[succinate]] ([[Succinate pathway]]; S). Whereas NS |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]], [[Gnaiger_2009_Int J Biochem Cell Bio

4 KB (604 words) - 08:32, 25 November 2023
SUIT-017 O2 mt D046
...OS capacity| OXPHOS capacity]] in the [[malate-anaplerotic pathway control state]]. ...OS capacity| OXPHOS capacity]] in the [[malate-anaplerotic pathway control state]].

3 KB (356 words) - 11:45, 29 February 2024
Gnaiger 1998 Biochim Biophys Acta
...ncy, ''J''max/''p''50, increased from the resting to the active state, despite the decrease of oxygen affinity, 1/''p''50. Consequentl ::::* [[State 2]] in this publication has the meaning of a [[LEAK]] state of respiration, without added adenylates (no ADP and no ATP) in the presenc

4 KB (505 words) - 16:27, 24 April 2023
Schoen 1990 Cyclobios
|title=Schön A, Haller T, Gnaiger E (1990) Hexokinase induced, steady state coupled mitochondria studied by injection calorimetry and respirometry. CYC |couplingstates=OXPHOS

554 bytes (67 words) - 04:48, 23 November 2021
Koopman 2015 Abstract MiP2015
...Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux. ...ction by the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) system. Altering the balance between glycolytic and mitochondrial ATP gene

3 KB (486 words) - 14:16, 9 November 2016
Christiansen 2015 J Vet Med Sci
...bstrate-specific quantitative and qualitative differences in mitochondrial OXPHOS capacity between the different types of oxidative muscles from cats. |couplingstates=LEAK, OXPHOS, ET

2 KB (328 words) - 17:33, 25 February 2020
Iglesias-Gonzalez 2013 J Neurosci Methods
|couplingstates=LEAK, OXPHOS ...e difference between ''E'' and ''P''. In many types of mitochondria, the [[OXPHOS-control ratio|''P/E'' ratio]] is >1.0 [1,2].

3 KB (349 words) - 14:26, 3 June 2020
Rivas 2018 Am J Physiol Endocrinol Metab
..., in the E + M group, exercise increased mitochondrial respiration in each state ( P ≤ 0.05), with respiration being comparable to that in the E group (ea |couplingstates=LEAK, OXPHOS

3 KB (373 words) - 08:14, 21 February 2020
Mueller 2019 Neurochem Int
...line respiration, complex I- and II-mediated ETS, as well as increased ROX state and ROX/ETS ratio, which are associated with ROS formation. Overall, we obs |couplingstates=LEAK, OXPHOS, ET

2 KB (297 words) - 14:16, 12 November 2019
Reverse electron flow from CII to CI
...[[Glycerophosphate |Gp]] without rotenone in the [[LEAK respiration|LEAK]] state. Addition of IQ-side inhibitors (ubiquinone-binding side of CI)

2 KB (211 words) - 12:20, 25 November 2020
FN
...rations by addition of [[NADH]]-generating substrates ([[N-pathway control state]], or CI-linked pathway control) in combination with one or several fatty a |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]]

2 KB (311 words) - 19:57, 1 January 2021
Du 2016 Aquat Toxicol
...aught Elizabeth River fish, acute benzo [a] pyrene exposure did not affect OxPhos function of the laboratory-reared F3 generation, supporting the heritabilit |couplingstates=LEAK, OXPHOS, ET

3 KB (402 words) - 17:52, 9 November 2017
Stride 2013 Eur J Heart Fail
...was to test mitochondrial OXPHOS capacity in LVSD myocardium compared with OXPHOS capacity in a comparable patient group without LVSD. ...y was highest (P ≤ 0.05) in LVSD compared with CONTROL. The stimulation of OXPHOS from octanoyl-l-carnitine titrations elicited ∼40% lower respiration in L

3 KB (371 words) - 15:45, 5 March 2019
Haller 1990 CYCLOBIOS Kinetics
...Haller T, Gnaiger E (1990) Kinetic control and reaction pressure in steady state coupled mitochondria. CYCLOBIOS Newsletter 4:63-6. |couplingstates=OXPHOS

606 bytes (68 words) - 04:47, 23 November 2021
SUIT-028
! Respiratory state ...ate with type N substrates, N''L'': Non-phosphorylating resting state with NADH-linked (type N) substrates pyruvate&glutamate&malate (PGM; withou

4 KB (574 words) - 16:13, 14 April 2020
Komlodi 2018 EBEC2018
...f mitochondrial respiration, H2O2 flux and the redox state of the Q-pool. ...Q-pool [1]. We aimed at investigating the relationship between the Q redox state, H2O2 and O2 fluxes with various fuel subs

4 KB (592 words) - 19:02, 10 January 2022
Cardoso 2022 Q10 Hamburg
|title=Cardoso LHD, Donnelly C, Komlodi T, Gnaiger E (2022) Coenzyme Q redox state and respiration in permeabilized HEK 293T cells: coupling and pathway contr ...rial inner membrane. ET capacity is measured in the noncoupled respiratory state after application of uncouplers, whereas LEAK respiration is assessed in th

4 KB (580 words) - 18:34, 5 May 2022
Sumbalova 2011 Abstract Mitochondrial Medicine
...ic acid cycle. Diagnostic protocols for the analysis of substrate-specific OXPHOS defects are required, which are traditionally performed in separate assays ...n increase of flux. The shift of ΔΨ was 4-6 mV both in the OXPHOS and LEAK state.

4 KB (526 words) - 18:19, 10 January 2022
SUIT-021
|abbr=OXPHOS (GM+S+Rot+Omy) ...support NADH-linked respiration. Oligomycin (Omy) is used to induce a LEAK state of respiration via the inhibition of the ATP synthase. Since higher concent

5 KB (697 words) - 15:58, 8 June 2020
Sobotka 2015 Physiol Res
...te respiration in an uncoupled state was less pronounced than in a coupled state in all the experimental models tested. When the concentration dependence of |couplingstates=OXPHOS, ET

2 KB (208 words) - 16:09, 13 November 2017
Cardoso 2022 Abstract Bioblast
...nitoring of respiration together with NAD(P)H autofluorescence and Q-redox state [1] provides unique analytical and diagnostic power in the study of mitocho ...Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. https://doi.org/10.26124/bec:2021

3 KB (463 words) - 08:34, 28 July 2022
Costa 1997 Am J Physiol Cell Physiol
...ndria, respectively. The ''K''(m)-O2 values found in the active state suggest a role for the normally occurring intracellular ''p''O2 range repor |couplingstates=LEAK, OXPHOS

2 KB (305 words) - 12:06, 8 November 2016
Power 2014 Physiol Rep
...approach offers a more powerful analysis of the effects of temperature on OXPHOS that cannot be measured using simple measures such as the traditional respi |couplingstates=LEAK, OXPHOS, ET

3 KB (365 words) - 15:40, 17 January 2023
Toleikis 2005 Biosci Rep
...se of succinate oxidation compared to pyruvate+malate, (iv) the highest in State 4 with succinate as a substrate. Similar results were obtained with the iso |couplingstates=LEAK, OXPHOS, ET

2 KB (233 words) - 16:18, 13 November 2017
Hickey 2014 Abstract MiP2014
...was protracted in STZ-diabetic mitochondria. ROS/O is higher in life-like OXPHOS states, and potential delays in the time to develop Δ''Ψ'' may delay ATP |couplingstates=OXPHOS

4 KB (547 words) - 17:26, 7 November 2016
E-L coupling efficiency
...e ''P'' in the OXPHOS state) with subsequent uncoupler titration to the ET state with maximum rate ''E''. The ''E-L'' coupling efficiency is based on measur ...993 Hypoxia |»Bioblast link]]«</ref>,<ref>Gnaiger E (2015) Cell ergometry: OXPHOS and E-L coupling efficiency. Mitochondr Physiol Network 2015-01-18. [[OXPHO

4 KB (522 words) - 23:34, 14 June 2022
FNS
...ed pathway control) in combination with [[succinate]] ([[S-pathway control state]]; S- or CII-linked) and one or several fatty acids, which are supplied to |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]]

3 KB (403 words) - 19:58, 1 January 2021
PM-pathway control state
'''MitoPathway control state:''' [[NADH Electron transfer-pathway state]] ::::» [[NADH electron transfer-pathway state]]

5 KB (603 words) - 15:33, 2 August 2023
Steady state
...ntration (oxystat mode; Gnaiger et al 2000, Harrison et al 2015) or steady-state pH (pH-stat more), yielding an expanded flexibility in experimental design == Hyphenation: Steady state or steady-state? ==

8 KB (1,115 words) - 03:00, 23 January 2023
Gnaiger 1998 J Exp Biol
...is necessary to prevent a large decrease in oxygen affinity in the active state. Upregulation of oxygen affinity provides a functional explanation of the e ...t from definitions by Chance, Williams 1955) has the meaning of a [[LEAK]] state of respiration, without added adenylates (no ADP and no ATP) in the presenc

4 KB (588 words) - 16:42, 24 April 2023
SUIT-031
...are designed to measure simultaneously O2 flux and the Q-redox state in isolated mitochondria and permeabilized cells. ...t D072]] simultaneous determination of O2 flux and the Q-redox state in isolated mitochondria and cells permeabilized previously to addition to

4 KB (623 words) - 17:57, 13 December 2023
SUIT-017
...osphorylation|OXPHOS state]] and of [[FNS]] and [[S]] in [[ET capacity| ET state]] is evaluated.

2 KB (325 words) - 23:49, 12 April 2021
Cardoso 2022 ESCI Bari
...getic fingerprinting with coupling and pathway control of coenzyme Q redox state and respiration in permeabilized HEK 293T cells. 56th Annual Sci ...fic segments of pathway and coupling control of oxidative phosphorylation (OXPHOS) [1].

4 KB (520 words) - 14:41, 30 May 2022
SUIT-002
...ays) and in [[ET capacity| ET state]] ([[FNSGp]] and [[SGp-pathway control state|SGp]]) can be evaluated by using this SUIT protocol. SUIT-002 can be extend :::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d

6 KB (809 words) - 18:41, 5 March 2024
SUIT-002 O2 pfi D006
:::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.

3 KB (439 words) - 18:44, 5 March 2024
Cardoso 2022a EBEC
...of the Q-junction, respectively, impacts the relation between the Q redox state and O2 flux in opposite directions. Therefore, our aim was to ch ...ifferent pathway-control-states. Coupling control was assessed in LEAK and OXPHOS states (absence and presence of 2.5 mM ADP) and ET capacity (CCCP uncoupler

4 KB (519 words) - 14:25, 23 August 2022
Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis
...to Complex I (CI) or Complex III (CIII) deficiency, respectively. Detailed OXPHOS analysis revealed striking differences between brain and liver mitochondria |topics=Redox state, Q-junction effect

2 KB (345 words) - 09:44, 28 February 2024
Makrecka-Kuka 2017 MiP2017
...ghtly impaired mitochondrial functionality (significant decrease in OXPHOS state respiration by 10%) just 24h after induction of endotoxemia. |couplingstates=OXPHOS

3 KB (453 words) - 12:17, 3 October 2017
SUIT-020
...f the ATP synthase. Since higher concentrations of Omy can decrease the ET state induced upon addition of uncoupler, the required concentration of Omy has t :::* NS-OXPHOS capacity provides a physiologically relevant estimate of maximum mitochondr

5 KB (756 words) - 15:03, 17 September 2020
SUIT-020 Fluo mt D033
:::* NS-OXPHOS capacity provides a physiologically relevant estimate of maximum mitochondr ...sed [[Mitochondrial membrane potential|mt-membrane potential]] in the LEAK state.

5 KB (655 words) - 08:41, 30 September 2020
Devin 1997 Biochim Biophys Acta
...er, under isoosmotic conditions, the salt concentration necessary for half state 3 stimulation depends on the cation involved: for inorganic cations, these |couplingstates=LEAK, OXPHOS, ET

2 KB (285 words) - 13:52, 15 January 2020
Phosphorylation pathway
== OXPHOS and substrate-level phosphorylation == ...pled, ADP- and Pi-saturated mitochondria in an [[electron-transfer-pathway state]], may be limited by the capacity of the phosphorylation system. Mitochondr

2 KB (251 words) - 11:27, 2 June 2020
Kontro 2016 Thesis
...A significant difference was found also between young HCR and old HCR rat OXPHOS (P) and ET-pathway (E) states (P: 53.7 ± 5.6 vs. 47.0 ± 9.4 pmol/s/mg, E: correlated with all respiratory states, i.e. LEAK (r = 0.44), OXPHOS (r = 0.71), CI (r = 0.67), and CII (r = 0.44; P<0.01 for all), and negative

3 KB (424 words) - 14:57, 13 November 2017
Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion Forum
...dence was that we were seeing final uncoupled respiration to be lower than state 3 respiration in samples with PC. This issue resolved when we switched to O |couplingstates=OXPHOS, ET

774 bytes (107 words) - 12:07, 28 March 2018
MitoEAGLE preprint 2017-09-21
...ET; proton leak, LEAK, residual oxygen consumption, ROX, State 2, State 3, State 4, normalization, flow, flux ...humb|Fig. 2. The proton circuit and coupling in oxidative phosphorylation (OXPHOS). Modified after [[Gnaiger_2014_MitoPathways#Chapter_1._Real-time_OXPHOS_an

3 KB (369 words) - 12:48, 23 May 2020
SUIT-007 O2 ce-pce D030
::: '''[[SUITbrowser]]:''' [[Glutamate-anaplerotic pathway control state|Glutamine/glutamate]] ...lutamate alone allows to analyze the glutamate-anaplerotic pathway control state.

2 KB (244 words) - 09:00, 17 September 2020
P/E control ratio
...HOS capacity by the [[phosphorylation system]]. The relative limitation of OXPHOS capacity by the capacity of the phosphorylation system is better expressed ...the ''P/E'' control ratio depends in part on [[Uncoupler |coupling]] of [[OXPHOS]], but mainly results from a diversity in the [[ET-excess control efficienc

4 KB (623 words) - 01:14, 31 December 2020
SUIT-021 Fluo mt D036
...f the ATP synthase. Since higher concentrations of Omy can decrease the ET state induced upon addition of uncoupler, the required concentration of Omy has t :::* NS-OXPHOS capacity provides a physiologically relevant estimate of maximum mitochondr

6 KB (834 words) - 14:07, 6 September 2021
Reyes 2018 EMBO Mol Med
...Ghezzi D, Zeviani M (2018) Mutations in TIMM50 compromise cell survival in OxPhos-dependent metabolic conditions. EMBO Mol Med 10:e8698. ...c dysfunction and that functional TIMM50 is essential for cell survival in OxPhos-dependent conditions.

2 KB (276 words) - 15:01, 12 November 2018
Chance 1962 J Biol Chem
...nts of adenosine diphosphatc will lead to reestablishment of the inhibited state of succinate oxidation after a short burst of respiration. 2. The inhibited state is not relieved by either phosphate or phosphate acceptors.

2 KB (260 words) - 17:18, 9 November 2017
Flux control efficiency
...h (stimulated or un-inhibited) flux; ''YX'' is the [[background state]] at low flux, upon which ''X'' acts. ...x from ''YX'' to ''ZX'' normalized for the reference state ''ZX''.

8 KB (1,272 words) - 18:27, 1 January 2021
SUIT-011
...y capacity ([[Oxidative phosphorylation|OXPHOS]] with [[NS-pathway control state|NS substrates]]) and coupling/pathway control''' ...ET state ([[NS-pathway control state|NS]] and [[Succinate pathway control state|S]]). SUIT-011 can be extended with the CIV assay module.

6 KB (951 words) - 15:35, 8 June 2020
EBEC2014
...ontana-Ayoub M, Gnaiger E (2014) The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during ...cessfully described the measured relationship between cytochrome oxidation state and oxygen consumption.

5 KB (720 words) - 12:35, 23 January 2019
Cardoso 2023 MiP2023
...iza HD]] Electron transfer from beta-oxidation and TCA cycle and impact of OXPHOS coupling on NADH and coenzyme Q redox states. ...ndirect proportion to respiration. The opposite correlations between redox state and respiratory rate were explained by the contrasting effects of varying e

4 KB (495 words) - 16:44, 12 July 2023
Coupling Quiz
{ ET } state. ...ed to OXPHOS-capacity, the oxidative ET-capacity reveals the limitation of OXPHOS-capacity mediated by the phosphorylation-pathway. By application of externa

5 KB (801 words) - 12:36, 27 January 2020
Neufer 2016 Abstract MitoFit Science Camp 2016
...system for measuring OXPHOS efficiency in PmFBs and provide evidence that OXPHOS efficiency increases as energy demand increases. |couplingstates=OXPHOS

2 KB (337 words) - 09:04, 1 July 2016
Gnaiger 2013 Abstract Neurocon Kolkata
...suggested to indicate systemic ‘mitochondrial fever’ in a pro-inflammatory state of oxidative stress and reduced mitochondrial biogenesis. This translates h |couplingstates=OXPHOS

3 KB (373 words) - 18:28, 10 January 2022
Adant 2022 Mol Metab
..., Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537 ...itochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system. Understanding the cellular metabolic re-wiring occurring in PMD is

3 KB (368 words) - 16:14, 10 August 2022
Kunz 1997 Mol Cell Biochem
...teins in saponin-skinned fibers. We detected substantially elevated steady state redox states of the mitochondrial NAD-system in the muscle fibers of these |topics=Redox state

1 KB (195 words) - 11:30, 23 February 2015
SUIT-029 O2 mt D066
|abbr=QC_imt_PM_T+OXPHOS+c+Omy_ET_G+S+Rot :::::::+ Evaluation of ET-state with NADH-linked substrates allows to calculate ET-coupling efficiency (1-'

4 KB (508 words) - 11:50, 15 March 2024
Osiki 2016 FASEB J
...rate-limiting enzyme of octanoylcarnitine oxidation. Respiration at Leak, Oxphos and ET-pathway states were measured using an Oroboros oxygraph. Citrate and ...all treatments. Citrate level in the medium increased by 2-fold at Oxphos state after 30 minutes.

3 KB (373 words) - 16:15, 26 March 2018
SUIT-014
...and ET state ([[NS-pathway control state|NS]], [[Succinate pathway control state|S]]) is also evaluated, covering the contribution of two pathways which are :::+ NS-OXPHOS capacity provides a physiologically relevant estimate of maximum mitochondr

4 KB (634 words) - 15:21, 8 June 2020
Tomar 2022 Biochim Biophys Acta Bioenerg
...OM mitochondria OxPhos efficiencies were higher than cortex mitochondria. State 3 respiration was low in heart mitochondria with succinate but increased si |couplingstates=LEAK, OXPHOS, ET

3 KB (386 words) - 11:58, 27 March 2023
SUIT-038 O2 mt D091
:::: 4. to analyse OXPHOS respiration and ET-capacity with various pathways (F, N, S, Gp) :::+ Pathway control in OXPHOS (N, NS, NSGp pathways) and in ET state (NSGp and SGp) can be observed.

2 KB (332 words) - 11:21, 14 April 2023
Fernstroem 2007 J Appl Physiol (1985)
...hondrial efficiency [amount of added ADP divided by oxygen consumed during state 3 (P/O ratio)] decreased Post-Ex by 9 and 6% (P < 0.05) with PC and PC + Py |couplingstates=LEAK, OXPHOS

2 KB (341 words) - 13:31, 6 July 2015
Moyes 1988 Am J Physiol
...t 30 degrees C. Changes in RCR values were due primarily to changes in the state 3 rate (in the presence of ADP). Mitochondrial pH was determined by measuri |couplingstates=LEAK, OXPHOS

2 KB (258 words) - 09:11, 9 November 2016
Coen 2015 Fatty Acid Oxidation O2k-Network Discussion Forum
...s and in combination with Pal, Mal, Glut, and Succ we see higher levels of state 3 respiration than without it. |couplingstates=OXPHOS

750 bytes (101 words) - 16:04, 7 November 2016
Pacheco 2008 Master Thesis
...ondrial respiration comparable to fresh muscle. However, the magnitudes of state 3 (ADP-driven) respiration rates for complex I substrates with malate and g ...e were lower than that of fresh muscle tissue. The significant increase in state 3 respiration upon addition of cytochrome c indicates that cryopreservation

2 KB (285 words) - 09:40, 8 November 2016
Additive effect of convergent electron flow
...and CIV, and if the capacity of the phosphorylation system does not limit OXPHOS capacity ([[Excess E-P capacity factor |excess ''E-P'' capacity factor]] is

3 KB (428 words) - 15:34, 31 January 2024
Fatty acid oxidation pathway control state
In the '''fatty acid oxidation pathway control state''' (F- or FAO-pathway), one or several fatty acids are supplied to feed ele |info=[[Electron-transfer-pathway state]], [[Gnaiger 2020 BEC MitoPathways]]

3 KB (456 words) - 16:12, 13 January 2022
Godtliebsen 2023 Autophagy
...dottir AB (2023) High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts. https://doi.org/10.1080/15548627 ...nonical autophagy mediators in lysosomal degradation of mitochondria after OXPHOS induction. Taken together, our high-resolution imaging approaches applied o

3 KB (387 words) - 16:35, 11 July 2023
SUIT-002 O2 mt D005
:::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.

4 KB (508 words) - 18:44, 5 March 2024
Komlodi 2022 Q10 Hamburg
...s: Continuous monitoring of pull and push control of respiration and redox state of the Q-mimetic CoQ2. Q10 Hamburg. ...mplemented into the Oroboros NextGen-O2k to monitor continuously the redox state of CoQ2 added as a Q-mimetic simultaneously with O2 consumption (Komlódi e

4 KB (559 words) - 18:39, 5 May 2022
Harrison 2015 J Appl Physiol
...tes and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia. J Appl Physiol 119:1210-8. https://doi.org/10.1152/jappl ...f ''p''O2. The relation between cytochrome oxidation state and oxygen consumption revealed a separation of distinct phases from mild t

3 KB (472 words) - 13:45, 1 May 2024
Layec 2016 Am J Physiol Endocrinol Metab
...index of mitochondrial capacity, exhibited the strongest correlation with State 3 respiration (r = 0.80, P < 0.05). Therefore, this study reveals that each |keywords=PCr recovery, State 3 respiration, Mitochondrial capacity assessment, Respirometry

3 KB (358 words) - 09:13, 8 November 2016
E-L net ET capacity
...slip and cation cycling: ''E'' = ''E-L''+''LP'' (see [[P-L net OXPHOS capacity]]).

781 bytes (111 words) - 01:32, 31 December 2020
Makrecka-Kuka 2017 Toxicol Lett
...drial LEAK state respiration with pyruvate by 30% without affecting OXPHOS state respiration. However, no significant changes in mitochondrial reactive oxyg |couplingstates=LEAK, OXPHOS, ET

3 KB (351 words) - 13:39, 7 March 2020
Komlodi 2017 MiPschool Obergurgl
...b> production in the LEAK state and O2 consumption in the OXHOS state establishes the concept that electron pressure generated by the linear S- a |topics=Flux control, Inhibitor, Q-junction effect, Redox state, Substrate

5 KB (694 words) - 18:54, 10 January 2022
Sumbalova 2011 Abstract Bordeaux
|keywords=High-resolution respirometry, OXPHOS, mitochondrial membrane potential, ROS production, brain mitochondria, O2k- ...eparations, to quantify maximum capacities of oxidative phosphorylation ([[OXPHOS]], ''P'') and of the electron transfer system ([[ETS]], ''E''). Functional

6 KB (803 words) - 18:16, 10 January 2022
Lemieux 2011 Abstract Bordeaux
...e=Lemieux H, Semsroth S, Antretter H, Hoefer D, Gnaiger E (2011) Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved ...lation. Under these conditions, the increase of respiration in the OXPHOS state at constant ET capacity indicates a mitochondrial dysfunction after cold pr

6 KB (874 words) - 18:21, 10 January 2022
Neyroud 2019 J Muscle Res Cell Motil
...mM adenosine diphosphate; p < 0.05) and acceptor control ratio (state III/state II) was 15% lower in the TB vs. N-TB (p < 0.05), with the latter sugges |couplingstates=OXPHOS

2 KB (246 words) - 12:12, 9 July 2019
Kadaja 2010 Exp Clin Cardiol
...ontent of cytochrome c was observed, which could limit the maximal rate of OXPHOS. The results are discussed with respect to relationships between the volume |couplingstates=OXPHOS

2 KB (282 words) - 10:57, 27 March 2018
P-L control efficiency
...ate 3]] is measured at saturating concentrations of ADP and Pi (State 3 = ''P''), then the [[respiratory acceptor control ratio]] RCR equals ''P/ » [[#Cell ergometry: OXPHOS-control and ET-coupling efficiency |'''MiPNet article''']]

9 KB (1,431 words) - 20:35, 19 March 2022
DeLany 2013 TOS
...0±491 ml/min; p< 0.03) in AAW. When combining groups, State 4, State 3 and State U respiration correlated positively with RMR (r=0.44, p<0.01; r=0.39, p<0.0 |couplingstates=LEAK, OXPHOS

3 KB (384 words) - 12:14, 28 March 2018
Gnaiger 2014 Abstract MiP2014
|title=Cell ergometry: OXPHOS and ET-pathway coupling efficiency. ...osite to uncoupling respiration, which yields [[ET-capacity]]. The OXPHOS state can be established experimentally by selective [[permeabilized cells |perme

8 KB (1,273 words) - 18:16, 7 November 2020
SUIT-002 O2 ce-pce D007
:::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.

4 KB (557 words) - 12:52, 12 April 2023
Tunholi 2016 J Invertebr Pathol
...comparison with the respective control group (5.14±0.25). In the uncoupled state, the infected snails consumed about 62% less oxygen than the infected snail |couplingstates=LEAK, OXPHOS, ET

2 KB (322 words) - 16:19, 13 November 2017
Cell ergometry
...er titrations are applied to determine the apparent ET-pathway excess over OXPHOS capacity ([[E-P control efficiency |''E-P'' control efficiency) and to calc = Cell ergometry and OXPHOS =

3 KB (459 words) - 01:26, 31 December 2020
Boelens 2013 J Bioenerg Biomembr
...ake and modulates Ca2+ uptake-independent respiration and redox state in cardiac isolated mitochondria. J Bioenerg Biomembr 45:203-18. ...]m, state 3 respiration was incrementally attenuated, and state 4 respiration enhanced, by higher [Mg2+]e. Thus, [Mg<

3 KB (504 words) - 15:35, 7 November 2016
Krumschnabel 2014 Methods Enzymol
...mandatory for any fluorophore applied for probing mtMP, in any respiratory state, type of tissue and pathophysiological condition. ...ometry, Mitochondrial membrane potential, Safranin, Complex I, Complex II, OXPHOS analysis, electron transfer-pathway

5 KB (600 words) - 21:53, 23 April 2024
Hoppel 2021 Front Physiol
.... There were inverse correlations between race time and N-linked substrate state PRE-POST, and changes in CK and LDH levels were significantly related to PL |couplingstates=LEAK, ROUTINE, OXPHOS, ET

4 KB (517 words) - 15:51, 7 June 2022
Ye 2013 Anal Biochem
...f these combined substrates, as well as through Complex IV. In protocol 2, state 3 rates are measured using palmitoylcarnitine to monitor fatty acid oxidati |keywords=Diagnosis; Systemic mitochondrial disease; Duroquinol oxidation; State 3 oxidation; Palmitoylcarnitine oxidation

2 KB (278 words) - 15:50, 4 June 2022
Du 1999 Free Radic Biol Med
...showed an increase in ADP/O (2.09 ± 0.14, ''p'' < .05) and a decrease in state 4 respiration (−22%) after anoxia/reoxygenation. In EPR spin-trapping mea |couplingstates=OXPHOS, ET

2 KB (232 words) - 17:51, 9 November 2017
SUIT-002 O2 ce-pce D007a
:::+ The protocol provides information on F-pathway in OXPHOS state. The low concentration of malate used in this protocol, typically 0.1 mM, d :::+ F-pathway (3Oct-2M.1) can be compared to FN-pathway (5P) in OXPHOS state.

4 KB (572 words) - 08:25, 12 October 2020
Pham 2014 Am J Physiol
...was protracted in STZ-diabetic mitochondria. ROS/O is higher in life-like OXPHOS states and potential delays in the time to develop Δ''Ψ'' may delay ATP s |couplingstates=LEAK, OXPHOS, ET

3 KB (431 words) - 15:40, 17 January 2023
Kovalev 2018 EMBS
..., respectively. The obtained results showed that larger mussels had higher OXPHOS rates than smaller ones. Since all mussels were of the same age, larger one |couplingstates=LEAK, OXPHOS, ET

3 KB (464 words) - 14:24, 26 February 2019
Van den Bergen 1994 Eur J Biochem
...ty of the cyanide-resistant pathway. The relation between rate and Q redox state for the external NADH dehydrogenase in potato callus mitochondria was found ...spiration rate is proportional to the redox state of the Q-pool. - ''redox state expressed as QH2 fraction''

7 KB (1,023 words) - 09:03, 16 July 2021
Onukwufor 2013 J Exp Biol
...ypoxia-reoxygenation-stimulated proton leak without rescuing the inhibited state 3 respiration suggesting that hypoxia-reoxygenation influences distinct asp |couplingstates=LEAK, OXPHOS, ET

3 KB (412 words) - 13:56, 14 August 2019
Cruz-Gregorio 2023 Phytother Res
...control of whole 4T1 cells. Additionally, α-M also decreases the levels of OXPHOS subunits of mitochondrial complexes I, II, III, and adenosine triphosphate

3 KB (383 words) - 14:04, 4 October 2023
Szibor 2019 Biochim Biophys Acta Bioenerg
...reduces the Q pool almost entirely (>90 %) irrespective of the respiratory state. AOX enhances the forward electron transfer (FET) from CII thereby decreasi |keywords=Alternative oxidase (AOX), Mitochondria, OXPHOS, Quinone pool, ROS, Xenotopic expression

3 KB (458 words) - 12:35, 3 April 2021
Liem 2008 Transl Res
...hich seem to converge at the level of the mitochondria where they increase state-2 respiration. |couplingstates=OXPHOS, ET

3 KB (363 words) - 15:10, 13 November 2017
Dlaskova 2008 Int J Biochem Cell Biol
...ub> production also in state 3, while similar attenuation was observed in state 4. Moreover, we have found that 5-(N-ethyl-N-isopropyl) amiloride is a real |couplingstates=OXPHOS

3 KB (360 words) - 15:45, 20 March 2015
SUIT-015 O2 pti D043
...of other, potentially interfering pathways, both in the LEAK state and in OXPHOS. :::+ FNS OXPHOS capacity comprises the most important pathways in many cell types and thus

2 KB (292 words) - 11:41, 29 February 2024
Komlodi 2021 MitoFit Q
...Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. https://doi.org/10.26124/mitofit: ...omlodi_2021_MitoFit_Q.pdf Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria]

5 KB (767 words) - 08:41, 8 January 2023
Lee 1996 Biol Bull
...000 {mu}M sulfide, suggesting that although cytochrome oxidation/reduction state may be regulated in the face of increased electron flux, regulation may fai |topics=Redox state

2 KB (305 words) - 10:07, 9 November 2016
SUIT protocol library
...Define pathway states |Define substrates and inhibitors]] for each pathway state. ...pathway control state]], [[S-pathway control state]], [[NS-pathway control state]]). Titrations may performed in a single step, or in multiple steps for seq

5 KB (721 words) - 15:01, 8 June 2020
Czerniczyniec 2015 J Bioenerg Biomembr
...t on respiratory chain. An increase of 2.2 fold in state 4 and 2.3 fold in state 3 in KCN-insensitive respiration was observed in striatal mitochondria from |couplingstates=LEAK, OXPHOS

3 KB (338 words) - 12:00, 11 July 2017
Staples 2013 Abstract MiP2013
...as the 13-lined ground squirrel (''Ictidomys tridecemlineatus''), enter a state of torpor where metabolic rate is suppressed by ca. 90%, and body temperatu ...ative phosphorylation. In liver mitochondria isolated from torpid animals, OXPHOS capacity fueled by succinate oxidation is ca. 70% lower than in euthermic a

4 KB (553 words) - 11:24, 28 April 2017
Burtscher 2020 Int J Mol Sci
...6/2 mice, except for cortical succinate-driven respiration. While the LEAK state relative to maximal respiratory capacity was reduced in adult mice in all a |couplingstates=LEAK, OXPHOS, ET

2 KB (314 words) - 19:54, 7 December 2021
Chance 1955 J Biol Chem-III
...R (1955) Respiratory enzymes in oxidative phosphorylation: III. The steady state. J Biol Chem 217:409-27. ...of ADP to a suspension of liver mitochondria causes changes in the steady state of the components of its respiratory chain. Spectrophotometric methods are

8 KB (1,251 words) - 02:44, 2 May 2024
Lark 2016 Am J Physiol Cell Physiol
...system for measuring OXPHOS efficiency in PmFBs and provide evidence that OXPHOS efficiency increases as energy demand increases. |couplingstates=LEAK, OXPHOS, ET

3 KB (413 words) - 16:41, 25 January 2021
Jezek 2014 Abstract MiP2014
...lated mitochondria at the active phosphorylating [[OXPHOS capacity |OXPHOS state]], which are, however, not encountered in situ [2]. Since it resides in MIN ...conformation [1]. Furthermore, ATP-synthase dimers vs. monomers ratio and OXPHOS/LEAK respiratory control ratios were higher under normoxia. Since these ATP

4 KB (472 words) - 10:49, 9 November 2016
Chance 1961 J Biol Chem-I
...n level of pyridine nucleotide than was observed aerobically in state 4. These observations suggest that the presence of adenosine 5’ |couplingstates=OXPHOS

3 KB (323 words) - 12:06, 8 November 2016
Chance 1961 J Biol Chem-IV
...n is likely to be small in state 3 and of some consequence in state 4. |couplingstates=OXPHOS

2 KB (258 words) - 09:54, 9 November 2016
Joergensen 2015 J Cereb Blood Flow Metab
...e there was no effect with pyruvate as substrate. Adding also succinate in state 3 resulted in a higher substrate control ratio (SCR) with PC, but a lower S |couplingstates=LEAK, OXPHOS

2 KB (302 words) - 17:42, 7 November 2016
Trewin 2017 PLOS ONE
.../sub>O2 emission responses to hyperinsulinemia in a respiratory state-specific manner, which may have implications for metabolic diseases involvi |couplingstates=LEAK, OXPHOS, ET

3 KB (425 words) - 22:08, 8 March 2020
Cedikova 2014 Evid Based Complement Alternat Med
...one (state ET-pathwayII) and Complex IV activity, but it did not influence state LEAK induced by oligomycin. Mitochondrial membrane potential was not affect |couplingstates=LEAK, OXPHOS, ET

2 KB (305 words) - 17:14, 9 November 2017
Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum
...nge of concentrations from 1 – 40 µM. We usually see a gradual increase in State 3 respiration with concentration increments (1, 2.5, 5, 10, 15, 40 µM). Ho |couplingstates=OXPHOS, ET

2 KB (301 words) - 14:21, 26 March 2018
Wessels 2019 Obesity (Silver Spring)
|abstract=The study aimed to investigate how obesity and glycemic state affect mitochondrial respiration and ATP-generating pathways in mature huma ...In both depots, the respiratory capacity was not affected by the glycemic state. A positive correlation between BMI and adipocyte lactate release was measu

2 KB (295 words) - 14:51, 15 May 2019
Lau 2019 Comp Biochem Physiol B Biochem Mol Biol
...onded similarly to an ''in vitro'' anoxia-recovery challenge and decreased state 3 respiration rate post-anoxia. Finally, NMRs had overall lower maximal com |couplingstates=LEAK, OXPHOS, ET

3 KB (344 words) - 16:40, 27 November 2019
Manoharan 2018 Thesis
...ference in liver homogenates. Oxygen consumption rate ratios normalized to OXPHOS showed several significant differences, therefore, revealing that responses |couplingstates=LEAK, OXPHOS, ET

3 KB (354 words) - 15:57, 28 March 2019
Petrenko 2010 Cryobiology
...ter DNP wash-out during WR, an improvement in the mitochondrial functional state (higher respiratory control indices and ATP levels, and a decrease in V(4) ...upling, Mitochondrial respiration, Bile formation, Pro-oxidant/antioxidant state

2 KB (293 words) - 12:13, 8 November 2016
Morris 2015 Abstract MiPschool Greenville 2015
...pyruvate, and L-PC compared to LCR regardless of diet. The differences in state 3 mitochondrial respiration due to diet are inversely associated with incre |couplingstates=OXPHOS, ET

3 KB (390 words) - 15:26, 13 November 2017
Gnaiger 2001 Respir Physiol
...2 flux ratios is shown in the transition from the OXPHOS to the LEAK state (from Figure 9b). '''(b)''' Oxygen limitation of respiration causes a redu ::::* rate in State 4 → ''L''

7 KB (963 words) - 06:05, 3 April 2024
Hong 2022 Cell Stem Cell
...nt of mitochondrial dynamics (by activating fission or preventing fusion), OXPHOS, or mitophagy. Thus, mitochondrial shape and physical networking controls s |keywords=Drp1, OXPHOS, Aging, Metabolism, Mitochondria, Mitochondrial dynamics, Mitophagy, Muscle

2 KB (331 words) - 18:26, 7 September 2022
Lund 2016 J Physiol
...of the present study was to investigate and compare hepatic mitochondrial OXPHOS capacity in T2DM, OB and non-obese controls (CON). State 3 respiration of complex I, II and IV and the CS activity did not differ in

2 KB (332 words) - 15:47, 5 March 2019
Aguilaniu 2001 J Biol Chem
...otein oxidation in G0 cells of ''Saccharomyces cerevisiae'' depends on the state rather than rate of respiration and is enhanced in pos9 but not yap1 mutant ...In contrast, during nitrogen starvation and excess carbon the respiratory state transition and stepwise increase in protein oxidation are markedly delayed

2 KB (351 words) - 16:16, 27 March 2018
LaNoue 1972 J Biol Chem
...late as substrates. Effects caused by changing the NAD oxidation-reduction state, the intramitochondrial ATP:ADP ratio, and the respiratory rate were studie ...n state of the adenine and guanine nucleotides and the oxidation-reduction state of the pyridine nucleotides. Changes of these parameters secondarily affect

5 KB (679 words) - 17:24, 16 January 2021
Salin 2018 Funct Ecol
...drion, with an increase in state 3 respiration combined with a decrease in state 4 respiration, suggesting a selective increase in the capacity to produce A ...ometry, ''In vivo'', Liver atrophy, MitoB probe, Mitochondrial respiratory state

3 KB (442 words) - 10:37, 30 August 2018
Kancirova 2014 Cardiovascular Research Supplements
...rfusion according to Langendorff. Parameters of oxidative phosphorylation (OXPHOS) in the isolated ...os Instruments, Austria). Mitochondrial respiration was stimulated by ADP (state III) using glutamate+malate and

3 KB (491 words) - 13:09, 23 January 2019
Kwast 1995 BBA
...tory control ratios exhibited broad, substrate-specific pH optima, whereas state 4 respiration rates increased gradually with increasing pH. P:O flux ratios |couplingstates=OXPHOS

2 KB (329 words) - 10:12, 10 August 2022
Coupling-control protocol
...rent [[coupling control state]]s at a constant [[electron-transfer-pathway state]]. [[Residual oxygen consumption]] (''Rox'') is finally evaluated for ''Rox ...ntrol of oxidative phosphorylation by coupling is of primary importance in OXPHOS analysis. To avoid misunderstandings, it is suggested to replace the term '

6 KB (874 words) - 10:49, 30 October 2023
Makrecka-Kuka 2015 Biomolecules
...ful optimization of assay conditions and reveals information in functional OXPHOS analysis beyond these assays carried out separately. |couplingstates=LEAK, ROUTINE, OXPHOS, ET

4 KB (484 words) - 19:56, 7 January 2024
Laner 2016 Abstract Mito Xmas Meeting Innsbruck
|title=OXPHOS and ET capacity in permeabilized fibers of canine superathletes. ...ked substrates. Both protocols were designed to provide a common reference state of NS-linked ET capacity, in comparison to separate N- and S-linked pathway

4 KB (530 words) - 18:38, 10 January 2022
Komlodi 2021 BEC Q
...Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. Bioenerg Commun 2021.3. https://d ...e capacities downstream of Q to O2, and (''3'') the load on the OXPHOS system utilizing or dissipating the protonmotive force.

6 KB (810 words) - 16:37, 21 January 2024
Timon-Gomez 2023 GIBB
...brane to certain compounds and mitochondrial preparations are required for OXPHOS analysis. ...trol. RP2 evaluates the effect of fatty acid oxidation (FAO) in the OXPHOS state. We demonstrated the applicability of SUIT-RP in different tissues (heart,

3 KB (337 words) - 13:18, 31 May 2023
Kancirova 2014 Cardiovasc Res
...rfusion according to Langendorff. Parameters of oxidative phosphorylation (OXPHOS) in the isolated cardiac mitochondria were determined by the method of high ...se of T-IRI. Reperfusion phase of T-IRI was characterized by a decrease in state III respiration in the group of hearts without RIP (65.9 %) and with RIP (3

3 KB (464 words) - 17:46, 7 November 2016
Gnaiger 2015 Abstract DrugDiscovery conference 2015
...d depth and scope by technological advances for diagnosis by comprehensive OXPHOS analysis using high-resolution respirometry. Fundamental questions of a cau ...ached in human ''V. lateralis'' characteristic of a low-grade inflammatory state (‘mitochondrial fever’). Onset of degenerative diseases (T2 diabetes, n

3 KB (362 words) - 14:51, 23 January 2019
Rhein 2010 PloS One
...y changes of Complexes III and IV of the oxidative phosphorylation system (OXPHOS) and in (ii) a drop of ATP levels which may finally instigate loss of synap ...re paralleled by an up-regulation of mitochondrial DNA. Improvement of the OXPHOS efficiency was stronger in APP cells than in control cells. In APP cells, t

3 KB (447 words) - 16:14, 9 November 2016
SUIT-005 O2 pfi D011
...n the [[LEAK respiration| LEAK state]] and in [[Oxidative phosphorylation| OXPHOS]]. :::+ [[FNS |FNS]] [[OXPHOS capacity| OXPHOS capacity]] comprises the most important pathways in many cell types and thu

3 KB (397 words) - 11:37, 29 February 2024
Nabben 2008 FEBS Lett
...her in UCP3Tg animals. To conclude, UCP3 overexpression leads to increased state 4o respiration and, in presence of 4-HNE, blunts the age-induced increase i |couplingstates=OXPHOS

2 KB (234 words) - 16:51, 19 March 2015
Fulton 2019 Abstract IOC139
...the hypothesis that athletic conditioning results in greater mitochondrial OxPhos capacity at high temperatures. ...ere used to evaluate the effect of ex vivo hyperthermia on skeletal muscle OxPhos. Skeletal muscle biopsies were obtained from the biceps femoris muscle aft

4 KB (545 words) - 12:36, 12 June 2019
Distelmaier 2012 Antioxid Redox Signal
...e the role of sROS in mitochondrial morphology, oxidative phosphorylation (OXPHOS), and cytosolic calcium (Ca(2+)) handling in healthy human skin fibroblasts ...trast, Trolox did not alter hydroethidium oxidation, cytosolic thiol redox state, mitochondrial NAD(P)H levels, or mitochondrial membrane potential. Whole g

3 KB (335 words) - 14:37, 27 March 2018
SUIT-018
...evaluate H2O2 flux in the NS-pathway in the LEAK and OXPHOS states. To decrease or increse the oxygen concentration in the O2k-Chamber, ...gen dependence of H2O2 production in LEAK and OXPHOS state.

5 KB (778 words) - 23:47, 12 April 2021
Stenberg 2014 PLoS One
...were increased in cardiogenic shock. Mitochondrial viability (RCR; state 3/state 4) and efficiency (ADP/O ratio) were unaffected. Our study demonstrates tha |couplingstates=LEAK, OXPHOS

2 KB (313 words) - 10:20, 8 November 2016
Chicco 2013 Abstract MiP2013
...Notably, data from newborn E-seal pups show markedly higher mass-specific OXPHOS and ET capacities and lower indices of LEAK compared to young adults, with ...idation and phosphorylation control of respiration despite a lower overall OXPHOS and ET capacity and a much greater capacity for LEAK respiration compared t

5 KB (691 words) - 11:16, 8 June 2020
Bettinazzi 2019 Cryobiology
...red to fresh tissues, independently of substrates combination, respiratory state and normalizing factor. However, the negative impact is not reflected at th ...ds=Bivalves, Cryopreservation, High-resolution respirometry, Mitochondria, OXPHOS, Unionids, Alternative oxidase

2 KB (252 words) - 12:17, 9 July 2019
Hedges 2018 FASEB J
...ed only in sedentary rats; in exercise-trained rats, ROS emissions in this state remained constant. We hypothesize that this effect may result from modulati |couplingstates=LEAK, OXPHOS, ET

2 KB (343 words) - 13:34, 7 March 2020
Hand 2012 Abstract Bioblast
...with Complex II substrate alone (succinate), which supports a much higher OXPHOS capacity than that observed through Complex I alone. The nature of the pote |couplingstates=OXPHOS, ET

5 KB (683 words) - 11:16, 8 June 2020
Boushel 2012 Am J Physiol Regul Integr Comp Physiol
...Indo (15%) compared to CON. The results indicate that indomethacin reduces State 3 mitochondrial respiration primarily at Complex I of the respiratory chain |couplingstates=LEAK, OXPHOS, ET

2 KB (347 words) - 17:00, 9 November 2017
Succinate pathway
...that supports succinate-linked respiration (succinate-induced respiratory state; previously used nomenclature: CII-linked respiration; SRot; see [[Gnaiger The S-pathway control state is usually induced in mt-preparations by addition of succinate&rotenone. In

8 KB (1,053 words) - 08:04, 30 March 2023
Kunz 1997 Anal Biochem
...d in the presence of the mitochondrial substrate octanoate elevated steady-state reduction levels of α-lipoamide dehydrogenase. This is an indication for t |couplingstates=OXPHOS

2 KB (275 words) - 16:06, 9 November 2016
Laner 2013 ASMRM
...O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013. ...shed world-wide for the diagnosis of mitochondrial respiratory control and OXPHOS analysis, reflected in [[O2k-Publications|>1,000 O2k-publications]] using t

3 KB (367 words) - 18:27, 10 January 2022
Gnaiger 2024 MitoFit
...II. Confusion between respiratory state 2 and LEAK states, or state 3 and OXPHOS capacity impedes accurate interpretation, as does imprecise usage of uncoup ...ron transfer system, Gibbs energy, Gibbs force, hypoxia, oxidative stress, OXPHOS coupling, protonmotive force

4 KB (472 words) - 09:49, 1 May 2024
Power 2014 Abstract MiP2014
...this would result in an impaired ATP supply by oxidative phosphorylation (OXPHOS) and hence compromise normal working heart function. ...approach offers a more powerful analysis of the effects of temperature on OXPHOS that cannot be measured using simple measures, such as the traditional RCR

3 KB (483 words) - 13:13, 16 June 2015
Mikulecky 2015 World Heart J
were determined, namely State 3 (S3), State 4 (S4), the rate |couplingstates=LEAK, OXPHOS

2 KB (285 words) - 15:18, 14 July 2016
Gnaiger 2017 MiPschool A1
|couplingstates=LEAK, ROUTINE, OXPHOS, ET ...R (1955) Respiratory enzymes in oxidative phosphorylation. III. The steady state. J Biol Chem 217:409-27. - [[Chance 1955 J Biol Chem-III |»Bioblast link«

2 KB (221 words) - 15:53, 14 February 2019
Chicco 2016b Abstract MitoFit Science Camp 2016
|title=OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic effic ...iling of snap frozen muscle biopsies was performed by LC/MS/MS at Colorado State University.

4 KB (578 words) - 18:37, 10 January 2022
Le 2012 Abstract Bioblast
...climatization to 5200m markedly alters substrate utilization and increases OXPHOS efficiency, with no effect on respiratory capacity in skeletal muscle mitoc ...0m markedly alters muscle mitochondrial substrate utilization and improves OXPHOS efficiency without eliciting any significant effect on muscle respiratory c

4 KB (476 words) - 15:07, 13 November 2017
SUIT-018 AmR mt D040
...lso advisable to either detect H2O2 flux at the same state for high (tissue hyperoxia; [O2]> ~100-110 µM) and low (tissue ...the oxygen dependence of H2O2 production in LEAK and OXPHOS states.

4 KB (625 words) - 12:09, 7 March 2024
Funk 2015 Abstract MiPschool Greenville 2015
...3 respiration in both the coupled and uncoupled state, as well as reduced State 4 respiration indicating less proton leakage. Conversely, the opposite was ...upported by the Diabetes Institute at Ohio University, the AMVETS, and the State of Ohio’s Eminent Scholar Program that includes a gift from Milton and La

3 KB (415 words) - 08:38, 21 July 2015
Laner 2015 Abstract MiPschool Greenville 2015
|title=Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes. ...ked substrates. Both protocols were designed to provide a common reference state of CI&II-linked ET capacity, in comparison to separate Complex I- and Compl

5 KB (640 words) - 18:36, 10 January 2022
Hall 2013 Biochim Biophys Acta
...2]] and [[State 4o]] oxygen flux as well as lowered ADP phosphorylation ([[State 3]]) and mitochondrial ATP synthesis. Polycation-mediated reduction of elec |couplingstates=LEAK, ROUTINE, OXPHOS, ET

3 KB (327 words) - 11:13, 22 November 2023

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