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| {{MitoPedia
| | #REDIRECT [[Succinate pathway]] |
| |abbr=S(Rot)
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| |description='''S(Rot)''': '''[[Succinate]]''' (S) supports electron flux through [[Complex II]] via flavin adenine dinucleotide (FADH2) into the membrane-bound [[electron transfer system]]. Inhibition of Complex I by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of [[Oxaloacetate|oxaloacetate]] which is a potent inhibitor of [[succinate dehydrogenase]]. After inhibition of CI by [[rotenone]], the NADH-linked dehydrogenases become inhibited by the redox shift from NAD<sup>+</sup> to NADH. Succinate dehydrogenase is activated by succinate and ATP, which explains in part the time-dependent increase of respiration in isolated mitochondria after addition of rotenone (first), succinate and ADP.
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| |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 4.1]]
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| {{MitoPedia methods}}
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| |mitopedia topic=Respiratory substrate-coupling state
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| [[File:S(Rot).jpg|400px|thumb|Succinate+rotenone, S(Rot). From [[Gnaiger 2014 MitoPathways]].]]
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