Residual oxygen consumption

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Residual oxygen consumption

Description

Residual oxygen consumption, ROX, is respiration due to oxidative side reactions remaining after inhibition of the electron transfer system (ETS) in mitochondrial preparations or cells, or in mt-preparations incubated without addition of fuel substrates (in the presence of ADP following a stimulation of the consumption of endogenous fuel substrates: State 2). Different conditions designated as ROX states (different combinations of inhibitors of CI, CII, CIII and CIV; or respiration of mt-preparations without addition of fuel substrates) may result in consistent or significantly different levels of oxygen consumption. Hence the best quantitative estimate of ROX has to be carefully evaluated. Mitochondrial respiration is frequently corrected for ROX as the baseline state. Then total ROUTINE, LEAK, OXPHOS or ETS (R, L, P and E) respiration is distinguished from the corresponding ROX-corrected, mitochondrial (ETS-linked) fluxes: R(mt), L(mt), P(mt) and E(mt). When expressing ROX as a fraction of ETS capacity (flux control ratio), total flux, E (not corrected for ROX), should be taken as the reference. ROX may be related to, but is of course different from ROS production. » MiPNet article

Abbreviation: ROX

Reference: Pathway control state, Gnaiger 2014 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

MitoPedia concepts: Respiratory state, Recommended 

MitoPedia topics: EAGLE 

» Keywords

» Ama

» Baseline state

» CI

» CII

» CIII

» Electron transfer system

» ETS

» Flux control ratio

» Instrumental background oxygen flux

» LEAK

» Mna

» Mitochondrial preparations

» OXPHOS

» Permeabilized tissue or cells

» Rot

» ROUTINE respiration

» State 2

» SUIT protocols

Residual oxygen consumption: a baseline correction of mitochondrial respiration

Gnaiger E (2016) Residual oxygen consumption: a baseline correction of mitochondrial respiration. Mitochondr Physiol Network 2016-01-28, updated 2016-11-19.

»

OROBOROS (2016) MiPNet

Abstract: Residual oxygen consumption (ROX) is sometimes referred to as 'non-mitochondrial respiration'. This may be correct to a large extent, but is not entirely accurate. In a preparation of purified isolated mitochondria, a small but significant ROX is observed after appropriate correction for instrumental background oxygen flux. In this case, ROX is 'mitochondrial non-ETS' rather than ‘non-mitochondrial’ respiration. In permeabilized and intact cells, ROX may be higher than in isolated mitochondria, and this increased part then would be a measurement of non-mitochondrial respiration. Keilin (1926) introduced and accurately defined the term residual respiration.

• O2k-Network Lab: AT Innsbruck Gnaiger E

Labels: MiParea: Respiration 

Pathway: ROX  HRR: Theory 

Abbreviations

• Previous editions (including Gnaiger 2014 MitoPathways): ROX-corrected ROUTINE, LEAK, OXPHOS or ETS (R, L, P and E) is distinguished from the corresponding apparent fluxes that are not corrected for ROX. Apparent fluxes (not corrected for ROX; R´, L´, P´ and E´) places the terminology into the conceptual context of physical chemistry (including kinetics), where e.g. apparent equilibrium constants, K_eq´ (apparent Michaelis-Menten kinetic constants, K_m´) are carefully distinguished from the less accessible (or inaccessible) 'true' constants, K_eq (K_m).

• Mitochondrial physiology nomenclature: Despite the fact that the previously used system of abbreviations is linked to a conceptually consistent framework of physical chemistry, generalized applicability may gain from a shift to a pragmatic emphasis of the experimental context of mitochondrial physiology. ROX correction is a baseline correction, which may be evaluated by a direct measurement within an experimental assay, or by independent test experiments for critical evaluation of the best estimate for a particular ROX correction. The ROX correction, therefore, may be emphasized by labelling the ROX-corrected values as mitochondrial (mt) fluxes: R(mt), L(mt), P(mt) and E(mt). Unfortunately, the total R, L, P and E values in this mitochondrial physiology system carry opposite meanings to the physical chemistry system of terminology. Confusion may be avoided in this context by explicit abbreviations, R(total), L(total), P(total) and E(total). Such lengthy abbreviations are not really practical.

• Agreement is required for paving the way towards consistent data reporting and managing a meaningful database (but agreement is not even reached in hot debates on caloric units [J versus cal] or frozen debates on commonly used temperature scales [°C versus Faraday]. Unfortunately, the two systems of abbreviations for ROX correction are not compatible. It is of practical importance to use short and well defined symbols. As a practical guideline, therefore, the simplest solution is to define in a given context, if data (and symbols used) refer to total or ROX-corrected results, and then use the simple symbols R, L, P and E in such a defined context.

Keilin 1929: Residual respiration

'KCN, H₂S and CO combine with some of the components of oxidase forming an inactive compound, with the result that cytochrome, or at least its components a’ and c’, as well as paraphenylenediamine added to the cells, are not oxidised. The respiratory process can be still carried out through the medium of some autoxidisable carriers such as haemochromogens, haematins, the component b’ of cytochrome, or some as yet unknown autoxidisable substances. This residual respiration, according to the nature of the cell, may represent a larger or smaller fraction of the total respiration of the cell.'

Keilin D (1929) Cytochrome and respiratory enzymes. Proc R Soc London Ser B 104:206-52.

Experimental tests on ROX

Is the preparation fully permeabilized?

ROX may be estimated in mitochondrial preparations in SUIT protocols which start at a respiratory state without added CHO substrates and without inhibitors, such that continuation of the SUIT protocol is possible for OXPHOS analysis. Some critical questions arise for evaluation, if this respiratory 'ROX state' represents a valid condition for estimation of ROX, and for comparison with ROX measured at the end of a SUIT protocol after titration of substrates and inhibitors of key elements of the electron transfer system (e.g. Rot, Mna and Ama as inhibitors of CI, CII and CIII). For evaluation of such an initial estimate of ROX, the following considerations are suggested.

1. A preparation of permeabilized tissue or cells, P_tic, may contain a fraction of intact, non-permeabilized cells. Non-permeabilized cells have ROUTINE respiration that
   1. is higher than ROX;
   2. is not stimulated by addition of ADP;
   3. is not diminished over prolonged periods of time due to the presence of cellular endogenous substrates;
   4. can be stimulated by uncoupler titration;
   5. can be inhibited by Rot (CI) and Ama (CII), etc.
2. Respiration of permeabilized tissue or cells incubated in a medium with significant concentrations of mitochondrial substrates
   1. is higher than ROX;
   2. is stimulated by addition of ADP (compare 1.2);
   3. is not diminished over prolonged periods of time due to the presence of exogenous substrates in the medium;
   4. can be stimulated by uncoupler titration,
   5. can be inhibited by Rot (CI) and Ama (CII), etc.
3. In contrast, the acutal level of ROX of fully permeabilized cells responds to such tests as
   1. ROX is obtained after gradual depletion of mitochondrial internal substrates (gradual decline of oxygen consumption);
   2. ADP or uncoupler titrations accelerate this decline;
   3. Rot and Ama do not inhibit ROX;
   4. uncoupler titration does not stimulate ROX.

Related terms in Bioblast

OXPHOS, P

ROUTINE, R

ETS, E

LEAK, L

ROX, R

» List of publications: Residual oxygen consumption

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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Cardoso 2021 MitoFit MgG	2021-01-29	Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. MitoFit Preprints 2021.1. doi:10.26124/mitofit:2021-0001	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Mouse	Heart
Avram 2021 Int J Mol Sci	2021	Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424.	ROUTINE ET LEAK	ROX	Intact cells	Human	Platelet
Furihata 2021 Commun Biol	2021	Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Klepinina 2021 PLoS One	2021	Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Wigner 2021 Sci Rep	2021	Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Other cell lines
Meng 2021 FEBS Open Bio	2021	Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio [Epub ahead of print].	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Kidney
Flouda 2021 Free Radic Biol Med	2021	Flouda K, Mercer J, Davies MJ, Hawkins CL (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radic Biol Med [Epub ahead of print].	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Schmidt 2021 Cancer Metab	2021	Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.	LEAK OXPHOS ET	N S Gp CIV ROX	Isolated mitochondria	Human	Liver
Yardeni 2021 Proc Natl Acad Sci U S A	2021	Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Thoral 2021 Biol Lett	2021	Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759.	LEAK OXPHOS	N CIV NS ROX	Homogenate	Fishes	Skeletal muscle
Roy Chowdhury 2021 Cancers (Basel)	2021	Roy Chowdhury S, Peltier C, Hou S, Singh A, Johnston JB, Gibson SB, Marshall A, Banerji V (2021) Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells. Cancers (Basel) 13:E354.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte
MiPNet21.17 BloodCellsIsolation	2020-10-22	O2k-Protocols: Isolation of blood cells for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Hassan 2020 MitoFit Preprint Arch	2020-04-30	Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. MitoFit Preprint Arch 2020.3 doi:10.26124/mitofit:200003.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human
Schneider 2020 PLoS One	2020	Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710.	LEAK OXPHOS	F N S CIV NS ROX	Permeabilized tissue	Rat	Heart
Pham 2020 Eur J Appl Physiol	2020	Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
McLaughlin 2020b Sci Rep	2020	McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Mouse	Heart Liver Kidney Fat
McCann 2020 Metabolites	2020	McCann MR, McHugh CE, Kirby M, Jennaro TS, Jones AE, Stringer KA, Puskarich MA (2020) A multivariate metabolomics method for estimating platelet mitochondrial oxygen consumption rates in patients with sepsis. Metabolites 10:E139.	LEAK ROUTINE ET	ROX	Intact cells	Human	Platelet
Visavadiya 2020 Mol Cell Biochem	2020	Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem [Epub ahead of print].	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Liver
De-Souza 2020 J Biol Chem	2020	De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.	LEAK OXPHOS	N Gp NS ROX	Isolated mitochondria Intact cells	Caenorhabditis elegans Saccharomyces cerevisiae
Lensu 2020 Preprints	2020	Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Linden J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides targeting Faecalibacterium prausnitzii prevent high fat diet-induced hepatic steatosis in rats. Preprints 2020:2020090241.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Cheng 2020 Am J Physiol Heart Circ Physiol	2020	Cheng TC, Philip JL, Tabima DM, Kumari S, Yakubov B, Frump AL, Hacker TA, Bellofiore A, Li R, Sun X, Goss KN, Lahm T, Chesler N (2020) Estrogen receptor alpha prevents right ventricular diastolic dysfunction and fibrosis in female rats . Am J Physiol Heart Circ Physiol [Epub ahead of print].	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Rat	Heart
Ferreira 2020 PLoS Genet	2020	Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Liver
Macedo 2020 FASEB J	2020	Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J [Epub ahead of print].	LEAK OXPHOS	F N CIV ROX	Intact organism Isolated mitochondria	Caenorhabditis elegans
Herpich 2020 Exp Gerontol	2020	Herpich C, Franz K, Klaus S, Müller-Werdan U, Ost M, Norman K (2020) Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells. Exp Gerontol [Epub ahead of print].	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Gvozdjakova 2020 Diagnostics (Basel)	2020	Gvozdjakova Anna, Sumbalova Zuzana, Kucharska Jarmila, Komlosi Maria, Rausova Zuzana, Vancova Olga, Szamosova Monika, Mojto Viliam(2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:E176.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Heinonen 2020 Sci Rep	2020	Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Pig	Heart
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis	2020	Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Isolated mitochondria Intact cells	Rat	Liver Nervous system
Chen 2020 Biochim Biophys Acta Mol Basis Dis	2020	Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Bhaskaran 2020 Aging Cell	2020	Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Romeiro 2020 bioRxiv	2020	Romeiro NC, Ferreira CM, Oliveira MF (2020) Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion. bioRxiv doi: https://doi.org/10.1101/2020.02.19.956870.	LEAK OXPHOS ET	S ROX	Permeabilized tissue	Mouse	Fat
Ayari 2020 Commun Biol	2020	Ayari Asma, Rosa-Calatrava Manuel, Lancel Steve, Barthelemy Johanna, Pizzorno Andres, Mayeuf-Louchart Alicia, Baron Morgane, Hot David, Deruyter Lucie, Soulard Daphnee, Julien Thomas, Faveeuw Christelle, Molendi-Coste Olivier, Dombrowicz David, Sedano Laura, Sencio Valentin, Le Goffic Ronan, Trottein Francois, Wolowczuk Isabelle (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fat
Groennebaek 2020 Cells	2020	Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Dulac 2020 J Physiol	2020	Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Kunz 2020 J Biol Chem	2020	Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem [Epub ahead of print].	LEAK ROUTINE OXPHOS ET	N NS ROX S	Permeabilized tissue Intact cells	Mouse	Skeletal muscle
Hraoui 2020 J Exp Biol	2020	Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Molluscs	Lung;gill
Pelster 2020 PLoS One	2020	Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (Arapaima gigas). PLoS One 15:e0236507.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Kidney Lung;gill
Liu 2020 Cell Death Dis	2020	Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Endothelial;epithelial;mesothelial cell
Messner 2020 Thesis	2020	Messner M (2020) Sorafenib resistance of hepatocellular carcinoma. PhD Thesis 130.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Pena 2020 Int J Chronic Dis	2020	Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Jian 2020 Cell Metab	2020	Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Mouse	Liver
Avila-Rojas 2020 Food Chem Toxicol	2020	Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Kidney
Frambach 2020 Biochim Biophys Acta Mol Basis Dis	2020	Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727.	LEAK OXPHOS	F N S Gp CIV Other combinations ROX	Permeabilized tissue	Mouse	Skeletal muscle
Fisher 2020 Placenta	2020	Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Human	Genital
Weger 2020 Sci Rep	2020	Weger M, Alpern D, Cherix A, Ghosal S, Grosse J, Russeil J, Gruetter R, de Kloet ER, Deplancke B, Sandi C (2020) Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Sci Rep 10:18308.	OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Roy Chowdhury 2020 Cancers (Basel)	2020	Roy Chowdhury S, Bouchard EDJ, Saleh R, Nugent Z, Peltier C, Mejia E, Hou S, McFall C, Squires M, Hewitt D, Davidson L, Shen GX, Johnston JB, Doucette C, Hatch GM, Fernyhough P, Marshall A, Gibson SB, Dawe DE, Banerji V (2020) Mitochondrial respiration correlates with prognostic markers in chronic lymphocytic leukemia and Is normalized by ibrutinib treatment. Cancers (Basel) 12:E650.	LEAK ET	ROX	Intact cells	Human	Lymphocyte
Macasoi 2020 Oncol Rep	2020	Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Rodriguez de Yurre 2020 An Acad Bras Cienc	2020	Rodriguez de Yurre A, Martins EGL, Lopez-Alarcon M, Cabral B, Vera N, Lopes JA, Galina A, Takiya CM, Lindoso RS, Vieyra A, SÁenz OC, Medei E (2020) Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model. An Acad Bras Cienc 92:e20191340.	LEAK OXPHOS	N NS ROX	Isolated mitochondria	Mouse	Heart
Baxter 2020 Elife	2020	Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Heart
Souza da Silva 2020 Mol Neurobiol	2020	Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Dawson 2020 J Exp Biol	2020	Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Fishes	Lung;gill
Chandramouleeswaran 2020 PLoS One	2020	Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klein-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H (2020) Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes. PLoS One 15:e0239625.	ROUTINE OXPHOS	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Endothelial;epithelial;mesothelial cell
Simard 2020b Metabolites	2020	Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in Drosophila melanogaster exposed to dietary sucrose. Metabolites 10:E411.	LEAK OXPHOS ET	N Gp NS Other combinations ROX	Permeabilized tissue	Drosophila
Jayakumari 2020 J Diabetes	2020	Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Human	Heart
Oliveira 2020 Anim Reprod	2020	Oliveira VS, Castro AJG, Domingues JT, Souza AZP, Scheffer DL, Latini A, Soares CHL, Van Der Kraak G, Silva FRMB (2020) A brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters sertoli cell secretion and mitochondrial activity. Anim Reprod 17:e20190116.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Genital
Rocha 2020 Sci Adv	2020	Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA (2020) Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv 6:eabc6250.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fat
Krajcova 2020 PLOS ONE	2020	Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142.	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Human	Heart
Burgin 2020 Int J Mol Sci	2020	Burgin HJ, Lopez Sanchez MIG, Smith CM, Trounce IA, McKenzie M (2020) Pioglitazone and deoxyribonucleoside combination treatment increases mitochondrial respiratory capacity in m.3243A>G MELAS cybrid cells. Int J Mol Sci 21:E2139.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Larsen 2020 Cardiovasc Drugs Ther	2020	Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther [Epub ahead of print].	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Tepp 2020 Biochim Biophys Acta Gen Subj	2020	Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Mouse	Heart Skeletal muscle
Zussman 2020 J Autoimmun	2020	Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437.	LEAK ET	N S Gp CIV NS ROX	Permeabilized tissue	Human	Genital
Simard 2020 Metabolites	2020	Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363.	LEAK OXPHOS ET	N S Gp NS ROX	Permeabilized tissue	Drosophila
Grewal 2020 Exp Neurol	2020	Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1:44 pp. doi:10.26124/bec:2020-0001.v1	LEAK OXPHOS ET	F N S Gp DQ CIV NS Other combinations ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria
Anderson 2020 Cells	2020	Anderson Vulczak, de Oliveira Souza Anderson, Ferrari Gustavo Duarte, Caleiro Seixas Azzolini Ana Elisa, Pereira-da-Silva Gabriela, Alberici Luciane Carla (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:628.	LEAK OXPHOS ET	N ROX	Permeabilized tissue	Mouse
Severo 2020 Life Sci	2020	Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Contreras Mostazo 2020 Cancers (Basel)	2020	Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV ROX	Permeabilized cells Intact cells	Human	Blood cells
Scrima 2020 bioRxiv	2020	Scrima R, Fugetto S, Capitanio N, Gatti DL (2020) Hemoglobin non-equilibrium oxygen dissociation curve. bioRxiv https://doi.org/10.1101/2020.01.09.900001.	LEAK	S ROX	Isolated mitochondria	Rat	Liver
Marrocco 2020 Thesis	2020	Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108.	LEAK OXPHOS ET	S ROX	Intact cells	Mouse	Macrophage-derived
Carvalho 2020 BMC Nutr	2020	Carvalho E, Adams SH, Boersheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Pig	Liver
Hosmann 2020 Acta Neurochir (Wien)	2020	Hosmann A, Milivojev N, Dumitrescu S, Reinprecht A, Weidinger A, Kozlov AV (2020) Cerebral nitric oxide and mitochondrial function in patients suffering aneurysmal subarachnoid hemorrhage-a translational approach. Acta Neurochir (Wien) [Epub ahead of print].	OXPHOS	N S CIV ROX	Homogenate	Rat	Nervous system
Padilla-Flores 2020 Biochem Biophys Res Commun	2020	Padilla-Flores T, Lopez-Gonzalez Z, Vaca L, Aparicio-Trejo OE, Briones-Herrera A, Riveros-Rosas H, Pedraza-Chaverri J, Leon-Aparicio D, Salvador C, Sampieri A, Escobar LI (2020) "Funny" channels in cardiac mitochondria modulate membrane potential and oxygen consumption. Biochem Biophys Res Commun 524:1030-36.	LEAK ROUTINE	ROX	Intact cells	Rat	Heart
De Souza 2020 Heliyon	2020	De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver HeLa
Zulkifli 2020 Nat Commun	2020	Zulkifli M, Neff JK, Timbalia SA, Garza NM, Chen Y, Watrous JD, Murgia M, Trivedi PP, Anderson SK, Tomar D, Nilsson R, Madesh M, Jain M, Gohil VM (2020) Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. Nat Commun 11:4866.	ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Schleier 2020 J Cardiovasc Transl Res	2020	Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res [Epub ahead of print].	LEAK OXPHOS	N NS ROX	Isolated mitochondria	Mouse	Heart
Risiglione 2020 Int J Mol Sci	2020	Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Gruenig 2020 Biochem Pharmacol	2020	Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860.	LEAK OXPHOS ET	N S DQ CIV ROX	Isolated mitochondria	Mouse	Liver
Courtes 2020 Brain Res Bull	2020	Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Mezeiova 2020 Eur J Med Chem	2020	Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J (2020) 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease. Eur J Med Chem [Epub ahead of print].	LEAK OXPHOS ET	ROX	Intact cells	Human	Neuroblastoma
Kline 2020 Nitric Oxide	2020	Kline JA, Puskarich MA, Pike JW, Zagorski J, Alves NJ (2020) Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism. Nitric Oxide 96:20-8.	LEAK ET	ROX	Intact cells	Human	Platelet Blood cells
Pinho 2020 PLoS Negl Trop Dis	2020	Pinho N, Wiśniewski JR, Dias-Lopes G, Saboia-Vahia L, Bombaça ACS, Mesquita-Rodrigues C, Menna-Barreto R, Cupolillo E, de Jesus JB, Padrón G, Cuervo P (2020) In-depth quantitative proteomics uncovers specie-specific metabolic programs in Leishmania (Viannia) species. PLoS Negl Trop Dis 14:e0008509.		ROX	Intact cells	Protists	Other cell lines
Bombaca 2020 Free Radic Biol Med	2020	Bombaça ACS, Brunoro GVF, Dias-Lopes G, Ennes-Vidal V, Carvalho PC, Perales J, d'Avila-Levy CM, Valente RH, Menna-Barreto RFS (2020) Glycolytic profile shift and antioxidant triggering in symbiont-free and H2O2-resistant Strigomonas culicis. Free Radic Biol Med 146:392-401.		ROX	Intact cells	Protists
Seitaj 2020 Cells	2020	Seitaj B, Maull F, Zhang L, Wüllner V, Wolf C, Schippers P, La Rovere R, Distler U, Tenzer S, Parys JB, Bultynck G, Methner A (2020) Transmembrane BAX inhibitor-1 motif containing protein 5 (TMBIM5) sustains mitochondrial structure, shape, and function by impacting the mitochondrial protein synthesis machinery. Cells 9:E2147.	LEAK ROUTINE ET	ROX	Intact cells	Human	Kidney
MitoEAGLE blood cells 1	2020	Åsander Frostner Eleonor*, Aburel Oana M*, Avram Vlad F*, Calabria Elisa, Castelo Rueda Maria Paulina*, Chamkha Imen*, Čižmárová Beata, Danila Maria-Daniela*, Doerrier Carolina*, Eckert Gunter P*, Ehinger Johannes K, Elmer Eskil*, Garcia-Souza Luiz F*, Gnaiger Erich*, Hoppel Florian*, Karabatsiakis Alexander*, Keppner Gloria, Kidere Dita*, Krako Jakovljević Nina, Labieniec-Watala Magdalena*, Lelcu Theia*, Micankova Petra, Michalak Slawomir*, Molina Anthony JA*, Pavlovic Kasja, Pichler Irene*, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina*, Silaidos Carmina*, Sjövall Fredrik*, Sobotka Ondrej*, Sumbalova Zuzana*, Swiniuch Daria, Vernerova Andrea*, Volani Chiara*, Vujacic-Mirski Ksenija*, Watala Cezary* (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *Confirmed	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Owiredu 2020 Am J Physiol Cell Physiol	2020	Owiredu S, Ranganathan A, Eckmann DM, Shofer FS, Hardy K, Lambert DS, Kelly M, Jang DH (2020) Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide poisoned individuals. Am J Physiol Cell Physiol 319:C129-35.	LEAK ROUTINE ET	S CIV ROX	Permeabilized cells Intact cells	Human	Blood cells
He 2020 Clin Transl Med	2020	He C, Gao P, Cui Y, Li Q, Li Y, Lu Z, Ma H, Zhao Y, Li L, Sun F, Chen, X, Jia H, Liu D, Yang G, Zheng H, Zhu Z (2020) Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes. Clin Transl Med 10:e205.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Nervous system
Xia 2020 Biomed Res Int	2020	Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Makrecka-Kuka 2020 Sci Rep	2020	Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. Sci Rep 10:21595.	LEAK OXPHOS	N S NS ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Close 2020 Cells	2020	Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J (2020) Disruption of beta-cell mitochondrial networks by the orphan nuclear receptor Nor1/Nr4a3. Cells 9:E168.	LEAK ROUTINE	N S CIV NS ROX	Permeabilized cells Intact cells	Rat	Islet cell;pancreas;thymus
Ugarteburu 2020 J Clin Med	2020	Ugarteburu O, Sánchez-Vilés M, Ramos J, Barcos-Rodríguez T, Garrabou G, García-Villoria J, Ribes A, Tort F (2020) Physiopathological bases of the disease caused by HACE1 mutations: alterations in autophagy, mitophagy and oxidative stress response. J Clin Med 9:E913.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Feng 2020 Int J Biol Macromol	2020	Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol 155:524-34.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Hexapods
Mikulas 2020 Materials	2020	Mikulás K, Komlódi T, Földes A, Sváb G, Horváth G, Nagy AM, Ambrus A, Gyulai-Gaál Sz, Gera I, Hermann P, Varga G, Tretter L (2020) Bioenergetic Impairment of triethylene glycol dimethacrylate- (TEGDMA-) treated dental pulp stem cells (DPSCs) and isolated brain mitochondria are amended by redox compound methylene blue. Materials (Basel) 13(16):3472.	OXPHOS ET ROUTINE	N S ROX	Isolated mitochondria Permeabilized cells Intact cells	Guinea pig Human	Stem cells
Cornelissen 2020 Hum Mol Genet	2020	Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Fibroblast
Residual oxygen consumption	2020	Gnaiger E (2020) Residual oxygen consumption: a baseline correction of mitochondrial respiration. Mitochondr Physiol Network (2016-01-28) last update 2020-11-11.		ROX
MitoEAGLE muscle 1	2020	Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08	LEAK OXPHOS ET	N NS S ROX	Permeabilized tissue	Human	Skeletal muscle
Irion 2020 Stem Cells Int	2020	Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Heart
Charles 2020 Nanomedicine (Lond)	2020	Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) [Epub ahead of print].	LEAK OXPHOS	N S CIV ROX	Isolated mitochondria	Human	Endothelial;epithelial;mesothelial cell
Tichanek 2020 Sci Rep	2020	Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Lin 2020 Preprints	2020	Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567.	LEAK ROUTINE OXPHOS ET	F N S Gp NS ROX	Permeabilized cells Intact cells	Human	Platelet
Evinova 2020 J Membr Biol	2020	Evinova A, Cizmarova B, Hatokova Z, Racay P (2020) High‑resolution respirometry in assessment of mitochondrial function in neuroblastoma SH‑SY5Y intact cells. J Membr Biol 253:129-36.	LEAK ROUTINE ET	N S ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Silaidos 2020 Mitochondrion	2020	Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Pola 2020 Invest New Drugs	2020	Pola M, Kolarova H, Ruzicka J, Zholobenko A, Modriansky M, Mosinger J, Bajgar R (2020) Effects of zinc porphyrin and zinc phthalocyanine derivatives in photodynamic anticancer therapy under different partial pressures of oxygen in vitro. Invest New Drugs [Epub ahead of print].	LEAK ROUTINE ET	ROX	Intact cells	Human	HeLa
Ost 2020 EMBO Rep	2020	Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Mouithys-Mickalad 2020 Chem Biol Interact	2020	Mouithys-Mickalad A, Ceusters J, Charif M, El Moualij B, Schoumacher M, Plyte S, Franck T, Bettendorff L, Pirotte B, Serteyn D, de Tullio P (2020) Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chem Biol Interact 331:109272.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Szibor 2020 J Biol Chem	2020	Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97.	LEAK OXPHOS	N S Gp CIV NS ROX	Isolated mitochondria Intact cells	Mouse	Nervous system
Keppner 2020 Thesis	2020	Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Anand 2020 Toxicol In Vitro	2020	Anand CR, Bhavya B, Jayakumar K, Harikrishnan VS, Gopala S (2020) Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia. Toxicol In Vitro [Epub ahead of print].	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Locatelli 2020 FASEB J	2020	Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria Intact cells	Human	Endothelial;epithelial;mesothelial cell
Yadav 2020 Cell Death Dis	2020	Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Human	Heart Stem cells
Brum 2020 Mol Neurobiol	2020	Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, Scussel R, Machado-de-Ávila RA, Dalla Corte CL, Soares FAA, Oliveira SM (2020) Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol Neurobiol 57:4202-17.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Nervous system
Esselun 2020 Neuromolecular Med	2020	Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med [Epub ahead of print].	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Hoffmann 2020 J Clin Endocrinol Metab	2020	Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Reutzel 2020 Oxid Med Cell Longev	2020	Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.	LEAK ET OXPHOS	N S CIV ROX	Isolated mitochondria	Mouse	Nervous system
Chen 2020 Chem Biol Interact	2020	Chen HY, Ho YJ, Chou HC, Liao EC, Tsai YT, Wei YS, Lin LH, Lin MW, Wang YS, Ko ML, Chan H (2020) TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact 331:109249.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Nervous system
Makrecka-Kuka 2020 Cardiovasc Drugs Ther	2020	Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther [Epub ahead of print].	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Heart
Lensu 2020 Nutrients	2020	Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Zhang 2020 Chemosphere	2020	Zhang Y, Li Y, Feng Q, Shao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere 248:126009.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Hexapods
Edmunds 2020 Mol Metab	2020	Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab 41:101051.	LEAK OXPHOS ET	F N ROX	Homogenate	Mouse	Liver
Cipullo 2020 Nucleic Acids Res	2020	Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res [Epub ahead of print].	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	HEK
Kanellopoulos 2020 Cell	2020	Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Drosophila	Nervous system Other cell lines
Guo 2020 Hum Gene Ther	2020	Guo Y, Zhang K, Gao X, Zhou Z, Liu Z, Yang K, Huang K, Yang Q, Long Q (2020) Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure-overload via improving mitochondrial function. Hum Gene Ther [Epub ahead of print].	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Heart
Ledur 2020 Sci Rep	2020	Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Musi 2020 Aging Cell	2020	Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Doig 2020 Skelet Muscle	2020	Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Brand 2020 J Clin Med	2020	Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.	LEAK OXPHOS ET	N CIV ROX	Permeabilized cells	Human	Lymphocyte
Dawid 2020 Biochim Biophys Acta Bioenerg	2020	Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.	LEAK ROUTINE OXPHOS ET	N S Gp NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human Mouse	Nervous system HEK
Battaglia 2020 Cell Death Dis	2020	Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells	Rat	Nervous system
Hayes 2020 Nutrients	2020	Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.	LEAK ROUTINE OXPHOS ET	N S Gp CIV ROX	Permeabilized cells Intact cells	Human	HeLa
Zhang 2020 Acta Pharmacol Sin	2020	Zhang L, Wang YN, Ju JM, Shabanova A, Li Y, Fang RN, Sun JB, Guo YY, Jin TZ, Liu YY, Li TY, Shan HL, Liang HH, Yang BF (2020) Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation. Acta Pharmacol Sin [Epub ahead of print].	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Heart
Al-Azab 2020 FEBS J	2020	Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.	LEAK ROUTINE OXPHOS ET	N ROX	Permeabilized cells Intact cells	Human	Other cell lines
Briones-Herrera 2020 Free Radic Biol Med	2020	Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Rat	Kidney
Stankova 2020 Int J Mol Sci	2020	Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.	LEAK OXPHOS	F N S Gp NS ROX	Homogenate	Mouse	Liver
Coppin 2020 Cell Death Dis	2020	Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.	LEAK ROUTINE OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells Intact cells	Human	Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell
Wei 2020 Cell Rep	2020	Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Rat	Kidney
Rondot 2020 Thesis	2020	Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Hexapods	Skeletal muscle
Palavicini 2020 JCI Insight	2020	Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Nervous system
Wang 2020 J Mol Med (Berl)	2020	Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61.	LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Yurre 2020 Arq Bras Cardiol	2020	Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37.	LEAK OXPHOS	N NS ROX	Isolated mitochondria	Mouse	Heart
Parker 2020 Thesis	2020	Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Piel 2020 PLoS One	2020	Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Liver Platelet
Chang 2020 J Biol Chem	2020	Chang L, Liu X, Diggle CP, Boyle JP, Hopkins PM, Shaw MA, Allen PD (2020) Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia. J Biol Chem [Epub ahead of print].	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Franco 2020 bioRxiv	2020	Franco JLM, Genoula M, Corral D, Duette G, Ferreyra M, Maio M, Dolotowicz MB, Aparicio-Trejo OE, Patiño-Martínez E, Fuentes F, Soldan V, Moraña EJ, Palmero D, Ostrowski M, Schierloh P, Sánchez-Torres C, Hernández-Pando R, Pedraza-Chaverri J, Rombouts Y, Layre E, Hudrisier D, Vérollet C, Neyrolles O, Sasiain MC, Lugo-Villarino G, Balboa L (2020) Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity. bioRxiv doi: https://doi.org/10.1101/2020.03.23.001818 .	LEAK ROUTINE	N S CIV ROX	Intact cells	Human	Macrophage-derived
Alahmad 2020 EMBO Mol Med	2020	Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med [Epub ahead of print].	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Fecker 2020 Biomolecules	2020	Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 10:E818.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Hroudova 2020 Mol Neurobiol	2020	Hroudová J, Nováková T, Korábečný J, Maliňák D, Górecki L, Fišar Z (2020) Effects of novel tacrine derivatives on mitochondrial energy metabolism and monoamine oxidase activity-in vitro study. Mol Neurobiol [Epub ahead of print].	OXPHOS	N S ROX	Isolated mitochondria	Pig	Nervous system
Karabatsiakis 2020 Transl Psychiatry	2020	Karabatsiakis DA, Schönfeldt-Lecuona PDC (2020) Depression, mitochondrial bioenergetics, and electroconvulsive therapy: a new approach towards personalized medicine in psychiatric treatment - a short review and current perspective. Transl Psychiatry 10:226.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Gnaiger 2020 BEC MitoPathways	2020	Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2: 112 pp. doi:10.26124/bec:2020-0002	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells	Human Mouse	Heart Skeletal muscle Fibroblast
Protasoni 2020 EMBO J	2020	Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Woessner 2020 J Appl Physiol (1985)	2020	Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Hijazi 2020 J Cell Sci	2020	Hijazi I, Knupp J, Chang A (2020) Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress. J Cell Sci 133:jcs241539.	ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Owiredu 2020 Toxicol Rep	2020	Owiredu S, Ranganathan A, Greenwood JC, Piel S, Janowska JI, Eckmann DM, Kelly M, Ehinger JK, Kilbaugh TJ, Jang DH (2020) In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning. Toxicol Rep 7:1263-71.	ROUTINE ET	CIV ROX	Intact cells	Human	Blood cells Other cell lines
Dawson 2020 Exp Gerontol	2020	Dawson NJ, Salmón P (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Exp Gerontol 133:110883.	LEAK ROUTINE ET	ROX	Intact cells	Birds	Blood cells
Bose 2020 Aging Cell	2020	Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell [Epub ahead of print].	LEAK OXPHOS	F N CIV NS ROX	Permeabilized tissue	Mouse	Heart
Vulczak 2020 Cells	2020	Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628.	LEAK OXPHOS ET	N ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Jespersen 2020 Sci Rep	2020	Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Rat	Heart
Rodriguez 2020 J Gerontol A Biol Sci Med Sci	2020	Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci [Epub ahead of print].	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Molluscs
Maeda 2020 J Cell Mol Med	2020	Maeda H, Kami D, Maeda R, Murata Y, Jo JI, Kitani T, Tabata Y, Matoba S, Gojo S (2020) TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes. J Cell Mol Med 24:5007-20.	LEAK ROUTINE OXPHOS ET	N ROX	Isolated mitochondria Intact cells	Rat	Heart
Pajuelo 2020 Cells	2020	Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	HEK
Ulgherait 2020 Nat Commun	2020	Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Drosophila
Assis-de-Lemos 2020 Curr Protoc Toxicol	2020	Assis-de-Lemos G, Ledur PF, Karmirian K, Rehen SK, Galina A (2020) A protocol to study mitochondrial function in human neural progenitors and iPSC-derived astrocytes. Curr Protoc Toxicol 85:e97.	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Janowska 2020 Toxicol In Vitro	2020	Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794.	LEAK ROUTINE ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet Blood cells
Fuchs 2020 J Funct Foods	2020	Fuchs C, Bakuradze T, Steinke R, Grewal R, Eckert GP, Richling E (2020) Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. J Funct Foods 70:103988.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Liver
Peruzzotti-Jametti 2020 bioRxiv	2020	Peruzzotti-Jametti L, Bernstock JD, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Kittel A, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2020) Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells. bioRxiv doi: https://doi.org/10.1101/2020.01.29.923441 .	LEAK	N S Gp CIV ROX	Permeabilized cells	Mouse	Stem cells
Falcao-Tebas 2020 J Physiol	2020	Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol [Epub ahead of print].	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Fisher 2020 J Physiol	2020	Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe JSM, Holland OJ, Perkins AV (2020) Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. J Physiol [Epub ahead of print].	OXPHOS ET	N NS ROX	Isolated mitochondria	Human	Genital
Baggio 2020 Neurotoxicology	2020	Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Zebrafish	Nervous system
Bianchi 2020 IUBMB Life	2020	Bianchi SE, Pegues MA, Dias CK, Mascia F, Doneda E, Pittol V, Rao A, Klamt F, Bassani VL (2020) Achyrocline satureioides compounds, achyrobichalcone and 3-O-methylquercetin, induce mitochondrial dysfunction and apoptosis in human breast cancer cell lines. IUBMB Life [Epub ahead of print].	ROUTINE	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Purhonen 2020 Nat Commun	2020	Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Liver Kidney
Almoiliqy 2020 Acta Pharmacol Sin	2020	Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Endothelial;epithelial;mesothelial cell
Magnesa 2020 Thesis	2020	Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Aparicio-Trejo 2020 Free Radic Biol Med	2020	Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.	LEAK OXPHOS	F N S ROX	Isolated mitochondria	Rat	Kidney
Gumpp 2020 Proc Natl Acad Sci U S A	2020	Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-Fernández L, Welz T, Gündel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Chabi 2019 MitoFit Preprint Arch EA	2019-10-10	Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MitoEAGLE.0001.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Gnaiger 2019 MitoFit Preprints	2019-08-30	Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6. — Published in BEC: 2020-05-20 Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1	LEAK OXPHOS ET	F N S Gp DQ CIV NS Other combinations ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria
Doerrier 2019 MitoFit Preprint Arch EA	2019-07-04	Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
MiPNet20.13 Safranin mt-membranepotential	2019-06-24	O2k-FluoRespirometry: HRR and simultaneous determination of mt-membrane potential with safranin or TMRM.	LEAK ET	S ROX	Homogenate	Mouse	Nervous system
Schoepf 2019 MitoFit Preprint Arch	2019-06-11	Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Eichelbrönner I, Sorn P, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2019) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. MitoFit Preprint Arch doi:10.26124/mitofit:190003. - 2020-03-20 Published in »Nature Communications 11:1487«	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Genital
Carteri 2019 Toxicol Lett	2019	Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Nervous system
Rose 2019 Am J Physiol Endocrinol Metab	2019	Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells Permeabilized tissue Intact cells	Human	Skeletal muscle Blood cells Platelet
Tiebe 2019 Sci Rep	2019	Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Crebl2 regulates cell metabolism in muscle and liver cells. Sci Rep 9:19869.	LEAK OXPHOS ROUTINE	F N Gp ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle Liver
Ahmed 2019 Mol Nutr Food Res	2019	Ahmed N, Tcheng M, Roma A, Buraczynski M, Jayanth P, Rea K, Akhtar TA, Spagnuolo PA (2019) Avocatin B protects against lipotoxicity and improves insulin sensitivity in diet-induced obesity. Mol Nutr Food Res 63:e1900688.	LEAK ROUTINE ET	N ROX	Intact cells	Mouse Rat	Skeletal muscle Islet cell;pancreas;thymus
Bajzikova 2019 Cell Metab	2019	Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416.	OXPHOS ET	N S ROX	Permeabilized cells Homogenate	Mouse	Endothelial;epithelial;mesothelial cell Genital Other cell lines
Reda 2019 Sci Rep	2019	Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Weinstein 2019 bioRxiv	2019	Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Other cell lines Lymphocyte
Castellano-Gonzalez 2019 Neurotox Res	2019	Castellano-Gonzalez G, Jacobs KR, Don E, Cole NJ, Adams S, Lim CK, Lovejoy DB, Guillemin GJ (2019) Kynurenine 3-monooxygenase activity in human primary neurons and effect on cellular bioenergetics identifies new neurotoxic mechanisms. Neurotox Res 35:530-41.	LEAK ET ROUTINE	ROX	Intact cells	Human	HEK
Li 2019 Int Urol Nephrol	2019	Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W (2019) Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol 51:1059-70.	ROUTINE OXPHOS ET LEAK	N S CIV NS ROX	Intact cells Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Brunetta 2019 J Funct Foods	2019	Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Anton 2019 Front Physiol	2019	Anton L, DeVine A, Polyak E, Olarerin-George A, Brown AG, Falk MJ, Elovitz MA (2019) HIF-1α stabilization increases miR-210 eliciting first trimester extravillous trophoblast mitochondrial dysfunction. Front Physiol 10:699.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Genital
Alvarez 2019 Chem Biol Interact	2019	Álvarez Santos MR, Duarte YB, Güiza FM, Romero Bohórquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Goldberg 2019 Biochem J	2019	Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2019) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.	LEAK ET	F N S NS Other combinations ROX	Isolated mitochondria	Mouse	Heart
Chroeis 2019 Basic Clin Pharmacol Toxicol	2019	Chroeis KM, Larsen S, Pedersen JS, Rygg MO, Boilsen AEB, Bendtsen F, Dela F (2019) Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue. Basic Clin Pharmacol Toxicol [Epub ahead of print].	LEAK OXPHOS	N S ROX	Intact cells	Human	Liver
Blais-Lecours 2019 Am J Respir Cell Mol Biol	2019	Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Burgess JK, Halayko AJ, Soliz J, Marsolais D (2019) Metabolic adaptation of airway smooth muscle cells to a SPHK2 substrate precedes cytostasis. Am J Respir Cell Mol Biol 62:35-42.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells	Human	Other cell lines
Heden 2019 Sci Adv	2019	Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019) Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv 5:eaax8352.	LEAK OXPHOS	F N S DQ CIV NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Dannheisig 2019 Cells	2019	Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019) Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux. Cells 8:E894.	LEAK ROUTINE ET	N S CIV NS ROX	Intact cells Permeabilized cells	Human	HeLa
Skrivergaard 2019 Viruses	2019	Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Intact cells	Human	Other cell lines HeLa
Ng 2019 J Biol Chem	2019	Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Perry 2019 J Mol Cell Cardiol	2019	Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.	LEAK OXPHOS	N S ROX	Isolated mitochondria Permeabilized cells	Rat	Heart
Gregg 2019 J Biol Chem	2019	Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66.	OXPHOS ET LEAK	N S NS ROX	Permeabilized tissue	Mouse	Islet cell;pancreas;thymus
Gonzalez-Armenta 2019 J Nutr	2019	Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502.	LEAK OXPHOS ET	F N S Gp NS ROX	Permeabilized tissue	Other mammals	Skeletal muscle
Latham 2019 J Anim Sci	2019	Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print].	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Havird 2019 Mitochondrion	2019	Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11.	LEAK OXPHOS	N S CIV NS ROX	Isolated mitochondria	Plants
Qaed 2019 Oxid Med Cell Longev	2019	Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxid Med Cell Longev 2019:6521218.	LEAK OXPHOS ET ROUTINE	N S NS ROX	Homogenate Isolated mitochondria Permeabilized cells Intact cells	Rat	Heart
Fisar 2019 Clin Biochem	2019	Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet Blood cells
Rocco-Machado 2019 Free Radic Biol Med	2019	Rocco-Machado N, Cosentino-Gomes D, Nascimento MT, Paes-Vieira L, Khan YA, Mittra B, Andrews NW, Meyer-Fernandes JR (2019) Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity. Free Radic Biol Med 143:341-53.	LEAK ROUTINE ET	ROX	Intact organism Intact cells	Eubacteria
Jaskiewicz 2019 J Clin Med	2019	Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694.	ROUTINE OXPHOS ET LEAK	N S NS ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle Other cell lines
Kirby 2019 Comp Biochem Physiol C Toxicol Pharmacol	2019	Kirby AR, Cox GK, Nelson D, Heuer RM, Stieglitz JD, Benetti DD, Grosell M, Crossley DA 2nd (2019) Acute crude oil exposure alters mitochondrial function and ADP affinity in cardiac muscle fibers of young adult Mahi-mahi (Coryphaena hippurus). Comp Biochem Physiol C Toxicol Pharmacol 218:88-95.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Heart
Sonjak 2019 J Gerontol A Biol Sci Med Sci	2019	Sonjak V, Jacob KJ, Spendiff S, Vuda M, Perez A, Miguez K, Minozzo FC, Spake C, Morais JA, Hepple RT (2019) Reduced mitochondrial content, elevated ROS, and modulation by denervation in skeletal muscle of pre-frail/frail elderly women. J Gerontol A Biol Sci Med Sci 74:1887-95.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Azevedo 2019 Food Chem Toxicol	2019	Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol 132:110694.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Rat	Liver
Braz-De-Melo 2019 Sci Rep	2019	Braz-De-Melo HA, Pasquarelli-do-Nascimento G, Corrêa R, das Neves Almeida R, de Oliveira Santos I, Prado PS, Picolo V, de Bem AF, Pizato N, Magalhães KG (2019) Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Sci Rep 9:20119.	LEAK ET	ROX	Intact cells	Human	Neuroblastoma
McManus 2019 Cell Metab	2019	McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90.	LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Dent 2019 J Appl Physiol (1985)	2019	Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) 127:1117-27.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Ruegsegger 2019 FASEB J	2019	Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72.	LEAK OXPHOS	N NS ROX	Isolated mitochondria	Mouse	Nervous system
Harhous 2019 J Mol Cell Cardiol	2019	Harhous Z, Badawi S, Bona NG, Pillot B, Augeul L, Paillard M, Booz GW, Canet-Soulas E, Ovize M, Kurdi M, Bidaux G (2019) Critical appraisal of STAT3 pattern in adult cardiomyocytes. J Mol Cell Cardiol 131:91-100.	OXPHOS ET	N CIV ROX	Isolated mitochondria	Mouse	Heart
Miranda-Silva 2019 Acta Physiologica	2019	Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact organ Permeabilized tissue Isolated mitochondria	Rat	Heart
Bettinazzi 2019 Proc Biol Sci	2019	Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708.	LEAK OXPHOS ET	N Gp CIV NS ROX	Permeabilized cells	Molluscs	Lung;gill Genital
Fiorenza 2019 FASEB J	2019	Fiorenza M, Lemminger AK, Marker M, Eibye K, Iaia FM, Bangsbo J, Hostrup M (2019) High-intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature-dependent manner in human skeletal muscle: implications for exercise performance. FASEB J 33:8976-89.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Deutschman 2019 J Cell Sci	2019	Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Bousseau 2019 FASEB J	2019	Bousseau S, Marchand M, Soleti R, Vergori L, Hilairet G, Recoquillon S, Le Mao M, Gueguen N, Khiati S, Clarion L, Bakalara N, Martinez MC, Germain S, Lenaers G, Andriantsitohaina R (2019) Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization. FASEB J 33:5864-75.	LEAK ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Teulier 2019 Comp Biochem Physiol A Mol Integr Physiol	2019	Teulier L, Thoral E, Queiros Q, McKenzie DJ, Roussel D, Dutto G, Gasset E, Bourjea J, Saraux C (2019) Muscle bioenergetics of two emblematic Mediterranean fish species: Sardina pilchardus and Sparus aurata. Comp Biochem Physiol A Mol Integr Physiol 235:174-79.	LEAK OXPHOS ET	F N NS ROX	Intact cells	Fishes	Skeletal muscle
Hsu 2019 J Clin Med	2019	Hsu CC, Tsai HH, Fu TC, Wang JS (2019) Exercise training enhances platelet mitochondrial bioenergetics in stroke patients: a randomized controlled trial. J Clin Med 8:E2186.	LEAK OXPHOS ET	F N S Gp NS ROX	Permeabilized cells	Human	Platelet Blood cells
Miranda Mendonca 2019 Neurochem Int	2019	Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17.	LEAK OXPHOS ET	N CIV ROX	Permeabilized tissue	Mouse	Nervous system
Benoist 2019 Sci Rep	2019	Benoist L, Chadet S, Genet T, Lefort C, Heraud A, Danila MD, Muntean DM, Baron C, Angoulvant D, Babuty D, Bourguignon T, Ivanes F (2019) Stimulation of P2Y11 receptor protects human cardiomyocytes against hypoxia/reoxygenation injury and involves PKCε signaling pathway. Sci Rep 9:11613.	LEAK ROUTINE ET	ROX	Intact cells	Human	Heart
McBride 2019 Arch Biochem Biophys	2019	McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.	LEAK OXPHOS	F N CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Diebold 2019 Nat Metab	2019	Diebold LP, Gil HJ, Gao P, Martinez CA, Weinberg SE, Chandel NS (2019) Mitochondrial Complex III is necessary for endothelial cell proliferation during angiogenesis. Nat Metab 1:158–71.	LEAK ROUTINE	ROX	Intact cells	Human	HUVEC
Ederle 2019 J Clin Med	2019	Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Blood cells
Malagrino 2019 Oxid Med Cell Longev	2019	Malagrinò F, Zuhra K, Mascolo L, Mastronicola D, Vicente JB, Forte E, Giuffrè A (2019) Hydrogen sulfide oxidation: adaptive changes in mitochondria of SW480 colorectal cancer cells upon exposure to hypoxia. Oxid Med Cell Longev 2019:8102936.	ROUTINE	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Robinson 2019 Am J Physiol Cell Physiol	2019	Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.	LEAK OXPHOS ET	F N S Gp NS Other combinations ROX	Permeabilized cells	Mouse Rat	Skeletal muscle
Kumari 2019 Am J Physiol Heart Circ Physiol	2019	Kumari S, Braun RK, Tetri L, Barton GP, Hacker TA, Goss KN (2019) Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart. Am J Physiol Heart Circ Physiol 317:H1272-81.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized tissue	Rat	Heart
Svensson 2019 Am J Physiol Endocrinol Metab	2019	Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S (2019) Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab 318:E145-51.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Driescher 2019 Heliyon	2019	Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357.	LEAK OXPHOS ET	F N CIV ROX	Permeabilized tissue	Rat	Heart
Laouafa 2019 Acta Physiol (Oxf)	2019	Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255.	LEAK OXPHOS ET	N S NS ROX CIV	Permeabilized tissue	Rat	Nervous system
Aubin 2019 Thesis	2019	Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99.	ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Lymphocyte
Bahhir 2019 PLoS Genet	2019	Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet 15:e1008410.	LEAK OXPHOS	N Gp CIV ROX	Homogenate	Drosophila
Mayer 2019 Lipids	2019	Mayer K, Sommer N, Hache K, Hecker A, Reiche S, Schneck E, Weissmann N, Seeger W, Hecker M (2019) Resolvin E1 improves mitochondrial function in human alveolar epithelial cells during severe inflammation. Lipids 54:53-65.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lung;gill Endothelial;epithelial;mesothelial cell Other cell lines
Detaille 2019 PLoS One	2019	Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385.	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Rat	Heart
Mazzoli 2019 Nutrients	2019	Mazzoli A, Crescenzo R, Cigliano L, Spagnuolo MS, Cancelliere R, Gatto C, Iossa S (2019) Early hepatic oxidative stress and mitochondrial changes following western diet in middle aged rats. Nutrients 11:E2670.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Moretti-Almeida 2019 Fungal Genet Biol	2019	Moretti-Almeida G, Thomazella DPT, Pereira GAG, Monteiro G (2019) Heterologous expression of an alternative oxidase from Moniliophthora perniciosa in Saccharomyces cerevisiae: antioxidant function and in vivo platform for the study of new drugs against witches' broom disease. Fungal Genet Biol 126:50-55.	OXPHOS	ROX	Isolated mitochondria	Saccharomyces cerevisiae
Fang 2019 Nat Commun	2019	Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA (2019) NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nat Commun 10:5284.	LEAK OXPHOS	F N S CIV ROX	Homogenate	Mouse	Heart Nervous system Liver
Huerta 2019 Aquat Toxicol	2019	Huerta B, Chung-Davidson YW, Bussy U, Zhang Y, Bazil JN, Li W (2019) Sea lamprey cardiac mitochondrial bioenergetics after exposure to TFM and its metabolites. Aquat Toxicol 219:105380.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Fishes	Heart
Hall 2019 Methods Mol Biol	2019	Hall A, Moghimi SM (2019) Determination of polycation-mediated perturbation of mitochondrial respiration in intact cells by high-resolution respirometry (Oxygraph-2k, OROBOROS). Methods Mol Biol 1943:313-22.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Ramalho 2019 J Leukoc Biol	2019	Ramalho T, Ramalingam L, Filgueiras L, Festuccia W, Jancar S, Moustaid-Moussa N (2019) Leukotriene-B4 modulates macrophage metabolism and fat loss in type 1 diabetic mice. J Leukoc Biol 106:665-75.	ROUTINE	ROX	Intact cells	Mouse	Macrophage-derived
Chen 2019 Ecotoxicol Environ Saf	2019	Chen H, Liu G, Qiao N, Kang Z, Hu L, Liao J, Yang F, Pang C, Liu B, Zeng Q, Li Y, Li Y (2019) Toxic effects of arsenic trioxide on spermatogonia are associated with oxidative stress, mitochondrial dysfunction, autophagy and metabolomic alterations. Ecotoxicol Environ Saf 190:110063.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Genital
Esteves 2019 Oncogene	2019	Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene 39:617-36.	LEAK ROUTINE OXPHOS ET	N ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Ma 2019 Biochem Biophys Res Commun	2019	Ma T, Lin S, Wang B, Wang Q, Xia W, Zhang H, Cui Y, He C, Wu H, Sun F, Zhao Z, Gao P, Zhu Z, Liu D (2019) TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction. Biochem Biophys Res Commun 519:674-81.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Heart
Zverova 2019 Neuropsychiatr Dis Treat	2019	Zvěřová M, Hroudová J, Fišar Z, Hansíková H, Kališová L, Kitzlerová E, Lambertová A, Raboch J (2019) Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder. Neuropsychiatr Dis Treat 15:233-40.	LEAK ROUTINE ET	ROX	Intact cells	Human	Platelet Blood cells
Nold 2019 Psychoneuroendocrinology	2019	Nold V, Sweatman C, Karabatsiakis A, Böck C, Bretschneider T, Lawless N, Fundel-Clemens K, Kolassa IT, Allers KA (2019) Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress. Psychoneuroendocrinology 107:148-59.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Grandoch 2019 Nat Metab	2019	Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M5, Haendeler J, Fischer JW (2019) 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1:546-59.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Fat
Berg 2019 Front Physiol	2019	Berg J, Undebakke V, Rasch-Halvorsen Ø, Aakerøy L, Sandbakk Ø, Tjønna AE (2019) Comparison of mitochondrial respiration in M. triceps brachii and M. vastus lateralis between elite cross-country skiers and physically active controls. Front Physiol 10:365.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Ahn 2019 J Cachexia Sarcopenia Muscle	2019	Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28.	OXPHOS LEAK	N S CIV NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Vaka 2019 Am J Physiol Regul Integr Comp Physiol	2019	Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.	LEAK OXPHOS ET	N CIV ROX	Intact cells Isolated mitochondria	Human Rat	Endothelial;epithelial;mesothelial cell Genital
Kunz 2019 Am J Physiol Endocrinol Metab	2019	Kunz HE, Dasari S, Lanza IR (2019) EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver. Am J Physiol Endocrinol Metab 317:E460-E472.	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Mouse	Skeletal muscle Liver
Naszai 2019 Sci Rep	2019	Nászai A, Terhes E, Kaszaki J, Boros M, Juhász L (2019) Ca(2+)N it be measured? Detection of extramitochondrial calcium movement with high-resolution FluoRespirometry. Sci Rep 9:19229.	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Rat	Liver
Repp 2019 Thesis	2019	Repp BM (2019) Identification and verification of novel disease-causing genes and therapy options for patients with mitochondrial disorders – Focus on ACAD9. PhD Thesis 178.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	HEK
Chang 2019 Br J Anaesth	2019	Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.	LEAK OXPHOS ET	N S CIV NS ROX		Human	Skeletal muscle
Bouitbir 2019 Toxicology	2019	Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology 426:152281.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells Permeabilized tissue	Rat Mouse	Heart
Campos 2019 Thesis	2019	Campos DF (2019) Os peixes amazônicos vivem perto dos seus limites térmicos? O efeito das mudanças climáticas sobre a ecofisiologia de peixes de Igarapé da Amazônia Central. PhD Thesis 106.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells	Fishes	Lung;gill
Pedrotti 2019 Sci Adv	2019	Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells	Mouse	Fat
Gvozdjakova 2019 Bratisl Lek Listy	2019	Gvozdjakova A, Sumbalova Z, Kucharska J, Chladekova A, Rausova Z, Vancova O, Komlosi M, Ulicna O, Mojto V (2019) Platelet mitochondrial bioenergetic analysis in patients with nephropathies and non-communicable diseases: a new method. Bratisl Lek Listy 120:630-35.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet Blood cells
Madlala 2019 Integr Food Nutr Metab	2019	Madlala HP, Maarman GJ, Ojuka E (2019) Fructose impairs mitochondrial respiration and substrate utilization in hepatocytes via the enzyme, glutamate oxaloacetate transaminase. Integr Food Nutr Metab doi: 10.15761/IFNM.1000228.	LEAK OXPHOS ET	N CIV ROX	Permeabilized cells	Human	Liver
Reyes-Fermin 2019 Antioxidants (Basel)	2019	Reyes-Fermín LM, Avila-Rojas SH, Aparicio-Trejo OE, Tapia E, Rivero I, Pedraza-Chaverri J (2019) The protective effect of alpha-mangostin against cisplatin-induced cell death in LLC-PK1 cells is associated to mitochondrial function preservation. Antioxidants (Basel) 8:E133.	LEAK ROUTINE ET	CIV ROX	Intact cells	Pig	Kidney
Dollerup 2019 J Physiol	2019	Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Pichaud 2019 Front Genet	2019	Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.	LEAK OXPHOS ET	N Gp CIV ROX	Permeabilized tissue	Drosophila	Skeletal muscle
Cardinale 2019 Front Physiol	2019	Cardinale DA, Larsen FJ, Lännerström J, Manselin T, Södergård O, Mijwel S, Lindholm P, Ekblom B, Boushel R (2019) Influence of hyperoxic-supplemented high-intensity interval training on hemotological and muscle mitochondrial adaptations in trained cyclists. Front Physiol 10:730.	LEAK OXPHOS ET	F N CIV NS ROX	Permeabilized tissue Isolated mitochondria	Human	Skeletal muscle
Simon 2019 J Biol Chem	2019	Simon MC, Reinbeck AL, Wessel C, Heindirk J, Jelenik T, Kaul K, Arreguin-Cano J, Strom A, Blaut M, Bäckhed F, Burkart V, Roden M (2019) Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in non-obese diabetic mice. J Biol Chem 295:969-80.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Luevano-Martinez 2019 Fungal Biol	2019	Luévano-Martínez LA, Caldeira da Silva CC, Nicastro GG, Schumacher RI, Kowaltowski AJ, Gomes SL (2019) Mitochondrial alternative oxidase is determinant for growth and sporulation in the early diverging fungus Blastocladiella emersonii. Fungal Biol 123:59-65.	ET	ROX CIV	Intact cells	Fungi
Shuvo 2019 J Bioenerg Biomembr	2019	Shuvo SR, Wiens LM, Subramaniam S, Treberg JR, Court DA (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less Neurospora crassa mitochondria. J Bioenerg Biomembr 51:341-54.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Fungi
Hamraz 2019 FASEB J	2019	Hamraz M, Abolhassani R, Andriamihaja M, Ransy C, Lenoir V, Schwartz L, Bouillaud F (2019) Hypertonic external medium represses cellular respiration and promotes Warburg/Crabtree effect. FASEB J 34:222-36.	LEAK ET OXPHOS	ROX N CIV	Isolated mitochondria Intact cells	Other mammals Human Rat	Endothelial;epithelial;mesothelial cell Liver HEK Neuroblastoma
D'Amico 2019 Mol Cell	2019	D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J (2019) The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Mol Cell 73:775-87.	OXPHOS	S NS ROX	Homogenate	Mouse	Skeletal muscle
Gaviraghi 2019 Anal Biochem	2019	Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes. Anal Biochem 576:33-41.	LEAK OXPHOS ET	N Gp CIV ROX	Permeabilized tissue	Hexapods	Skeletal muscle
Ruegsegger 2019 JCI Insight	2019	Ruegsegger GN, Vanderboom PM, Dasari S, Klaus KA, Kabiraj P, McCarthy CB, Lucchinetti CF, Nair KS (2019) Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. JCI Insight 4:130681.	LEAK OXPHOS ET	ROX	Isolated mitochondria	Mouse	Nervous system
Crescenzo 2019 Mol Neurobiol	2019	Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Mueller 2019 Neurochem Int	2019	Mueller TE, Nunes MEM, Rodrigues NR, Fontana BD, Hartmann DD, Franco JL, Rosemberg DB (2019) Neurochemical mechanisms underlying acute and chronic ethanol-mediated responses in zebrafish: The role of mitochondrial bioenergetics. Neurochem Int 131:104584.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Zebrafish	Nervous system
Holsgrove 2019 Thesis	2019	Holsgrove A (2019) The effect of temperature on cardiac energetics in the rainbow trout, Onchorhynchus mykiss. Phd Thesis 166.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Fishes	Heart
Greenway 2019 J Evol Biol	2019	Greenway EVG, Cirino LA, Wilner D, Somjee U, Anagnostou ME, Hepple RT, Miller CW (2019) Extreme variation in testes size in an insect is linked to recent mating activity. J Evol Biol 33:142-50.	LEAK OXPHOS	N CIV NS ROX	Permeabilized cells	Hexapods	Genital
Gaiser 2019 Adv Ther (Weinh)	2019	Gaiser A, Hafner S, Schmiech M, Büchele B, Schäfer P, Arnim CA, Calzia, E, Feuring‐Buske M, Buske C, Vick B, Jeremias I, Syrovets T, Simmet T (2019) Gold nanoparticles with selective antileukemic activity in vitro and in vivo target mitochondrial respiration. Adv Ther (Weinh) doi:10.1002/adtp.201800149.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Scavuzzo 2019 J Neurophysiol	2019	Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Nervous system
Axton 2019 J Nutr	2019	Axton ER, Beaver LM, St Mary L, Truong L, Logan CR, Spagnoli S, Prater MC, Keller RM, Garcia-Jaramillo M, Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM, Tanguay RL, Stevens JF, Hord NG (2019) Treatment with nitrate, but not nitrite, lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish. J Nutr 00:1–13.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Zebrafish	Skeletal muscle
Inigo 2019 Mol Metab	2019	Inigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg EE (2019) Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab 34:1-15.	LEAK OXPHOS	F N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Catalao 2019 Brain Res	2019	Catalão CHR, Souza AO, Santos-Júnior NN, da Silva SC, da Costa LHA, Alberici LC, Rocha MJA, da Silva Lopes L (2019) Kaolin-induced hydrocephalus causes acetylcholinesterase activity dysfunction following hypothalamic damage in infant rats. Brain Res 1724:146408.	LEAK OXPHOS ET	N ROX	Homogenate	Rat	Nervous system
Veyrat-Durebex 2019 Mol Neurobiol	2019	Veyrat-Durebex C, Bris C, Codron P, Bocca C, Chupin S, Corcia P, Vourc'h P, Hergesheimer R, Cassereau J, Funalot B, Andres CR, Lenaers G, Couratier P, Reynier P, Blasco H (2019) Metabo-lipidomics of fibroblasts and mitochondrial-endoplasmic reticulum extracts from ALS patients shows alterations in purine, pyrimidine, energetic, and phospholipid metabolisms. Mol Neurobiol 56:5780-91.	LEAK ET ROUTINE	ROX	Intact cells	Human	Fibroblast
Halle 2019 Am J Physiol Regul Integr Comp Physiol	2019	Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue Intact cells	Mouse	Skeletal muscle Liver Fat
Noz 2019 J Am Heart Assoc	2019	Noz MP, Hartman YAW, Hopman MTE, Willems PHGM, Tack CJ, Joosten LAB, Netea MG, Thijssen DHJ, Riksen NP (2019) Sixteen-week physical activity intervention in subjects with increased cardiometabolic risk shifts innate immune function towards a less proinflammatory state. J Am Heart Assoc 8:e013764.	LEAK ET	ROX	Intact cells	Human	Blood cells
Poudel 2019 Can J Physiol Pharmacol	2019	Poudel A, Zhou JY, Mekala N, Welchko R, Rosca MG, Li L (2019) Berberine hydrochloride protects against cytokine-induced inflammation through multiple pathways in undifferentiated C2C12 myoblast cells. Can J Physiol Pharmacol 97:699-707.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Spinazzi 2019 Proc Natl Acad Sci U S A	2019	Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells Permeabilized cells Isolated mitochondria	Mouse	Nervous system
Long 2019 Methods Mol Biol	2019	Long Q, Huang L, Huang K, Yang Q (2019) Assessing mitochondrial bioenergetics in isolated mitochondria from mouse heart tissues using Oroboros Oxygraph-2k. Methods Mol Biol 1966:237-46.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Heart
Thomas 2019 Redox Biol	2019	Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155.	LEAK OXPHOS ET	N S NS ROX	Intact cells	Rat	Liver
Kopinski 2019 Proc Natl Acad Sci U S A	2019	Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Other cell lines
Monteiro 2019 J Bioenerg Biomembr	2019	Monteiro J, Assis-de-Lemos G, de-Souza-Ferreira E, Marques AM, Neves GA, Silveira MS, Galina A (2019) Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. J Bioenerg Biomembr 52:1-15.	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Mouse	Nervous system
Wessels 2019 Obesity (Silver Spring)	2019	Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Human	Fat
Garnham 2019 J Cachexia Sarcopenia Muscle	2019	Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle 11:79-88.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Szibor 2019 Biochim Biophys Acta Bioenerg	2019	Szibor Marten, Gainutdinov Timur, Fernandez-Vizarra Erika, Dufour Eric, Gizatullina Zemfira, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Viscomi Carlo, Gellerich Frank Norbert, Moore Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Rawat 2019 J Mol Biol	2019	Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015.	OXPHOS LEAK	N S CIV ROX	Permeabilized cells	Mouse	Nervous system Other cell lines
Bettinazzi 2019 Cryobiology	2019	Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.	LEAK OXPHOS ET	N Gp CIV NS ROX S Other combinations	Permeabilized tissue	Molluscs	Lung;gill
McMurray 2019 FASEB J	2019	McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26.	LEAK OXPHOS	F N S CIV ROX	Permeabilized tissue	Mouse	Skeletal muscle
Lemieux 2019 bioRxiv	2019	Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse	Blood cells
Dechandt 2019 Front Neurol	2019	Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007.	LEAK OXPHOS ET	N ROX	Permeabilized tissue	Rat	Nervous system
Cesnekova 2019 Thesis	2019	Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133.	OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	HEK
Halling 2019 Am J Physiol Endocrinol Metab	2019	Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Langley 2019 Biochim Biophys Acta Mol Basis Dis	2019	Langley MR, Yoon H, Kim HN, Choi CI, Simon W, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA (2019) High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochim Biophys Acta Mol Basis Dis 1866:165630.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Nervous system
Fernando 2019 Exp Gerontol	2019	Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Gururaja Rao 2019 Cells	2019	Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Drosophila
Kluckova 2019 FASEB J	2019	Kluckova K, Thakker A, Vettore L, Escribano-Gonzalez C, Hindshaw RL, Tearle JLE, Goncalves J, Kaul B, Lavery GG, Favier J, Tennant DA (2019) Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase function. FASEB J 34:303-315.	LEAK ROUTINE OXPHOS ET	F N NS ROX	Permeabilized cells Intact cells	Mouse	Nervous system
Zhu 2019 Aging Cell	2019	Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883.	LEAK OXPHOS ET	N NS S ROX	Isolated mitochondria	Mouse	Liver
Sundstroem 2019 Acta Neuropathol Commun	2019	Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55.	ET LEAK	N S NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Oakey 2019 Wellcome Open Res	2019	Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG (2019) Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion. Wellcome Open Res 3:147.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Lerchner 2019 Anal Bioanal Chem	2019	Lerchner J, Sartori MR, Volpe POL, Lander N, Mertens F, Vercesi AE (2019) Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. Anal Bioanal Chem 411:3763-68.	LEAK OXPHOS ET	ROX	Intact cells	Protists
Wolf 2019 Cells	2019	Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289.	LEAK ROUTINE ET OXPHOS	ROX N NS	Intact cells Permeabilized cells	Mouse	Fibroblast
Glombik 2019 Neurotox Res	2019	Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Nervous system
Cormier 2019 Sci Rep	2019	Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531.	LEAK OXPHOS ET	N Gp NS ROX CIV	Permeabilized tissue	Drosophila	Skeletal muscle
Germain 2019 Int J Med Sci	2019	Germain N, Dessein AF, Vienne JC, Dobbelaere D, Mention K, Joncquel M, Dekiouk S, Laine W, Kluza J, Marchetti P (2019) First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: A preliminary study. Int J Med Sci 16:931-38.	LEAK ET	ROX N	Intact cells	Human	Fibroblast
Baekkerud 2019 Cardiovasc Toxicol	2019	Bækkerud FH, Salerno S, Ceriotti P, Morland C, Storm-Mathisen J, Bergersen LH, Høydal MA, Catalucci D, Stølen TO (2019) High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovasc Toxicol 19:422-31.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Heart
Kumar 2019 Free Radic Biol Med	2019	Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99.	LEAK ROUTINE OXPHOS ET	F N S DQ CIV NS ROX	Permeabilized cells Permeabilized tissue Intact cells	Mouse	Skeletal muscle
Kladnicka 2019 Physiol Res	2019	Kladnická I, Čedíková M, Kripnerová M, Dvořáková J, Kohoutová M, Tůma Z, Müllerová D, Kuncová J (2019) Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res 68:287-96.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fat Stem cells
Hafen 2019 J Appl Physiol (1985)	2019	Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Karusheva 2019 Am J Clin Nutr	2019	Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M (2019) Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr 110:1098-107.	LEAK OXPHOS ET	F N NS ROX	Permeabilized tissue Isolated mitochondria	Human	Skeletal muscle
Thome 2019 Am J Physiol Cell Physiol	2019	Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13.	LEAK ROUTINE OXPHOS ET	N NS ROX	Isolated mitochondria Intact cells	Mouse	Skeletal muscle
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis	2019	Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Doig 2019 bioRxiv	2019	Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Sanchez-de-Diego 2019 iScience	2019	Sánchez-de-Diego C, Artigas N, Pimenta-Lopes C, Valer JA, Torrejon B, Gama-Pérez P, Villena JA, Garcia-Roves PM, Rosa JL, Ventura F (2019) Glucose restriction promotes osteocyte specification by activating a PGC-1α-dependent transcriptional program. iScience 15:79-94.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Other cell lines
Zhang 2019 Nephron	2019	Zhang R, Wang X, Gao Q, Jiang H, Zhang S, Lu M, Liu F, Xue X (2019) Taurine supplementation reverses diabetes-induced podocytes injury via modulation of the CSE/TRPC6 axis and improvement of mitochondrial function. Nephron 144:84-95.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Intact cells Permeabilized cells	Mouse	Kidney
Krylova 2019 Mitochondrion	2019	Krylova TD, Sheremet NL, Tabakov VY, Lyamzaev KG, Itkis YS, Tsygankova PG, Andreeva NA, Shmelkova MS, Nevinitsyna TA, Kadyshev VV, Zakharova EY (2019) Three rare pathogenic mtDNA substitutions in LHON patients with low heteroplasmy. Mitochondrion 50:139-144.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Chao 2019 J Appl Physiol (1985)	2019	Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) 126:1541-49.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Pig	Skeletal muscle
Papadimitriou 2019 Sci Rep	2019	Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol	2019	Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21.	OXPHOS ET LEAK	N S Gp CIV NS ROX	Permeabilized tissue	Other invertebrates	Skeletal muscle
Cruz-Gregorio 2019 Biomolecules	2019	Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Coronado-Martinez I, Pedraza-Chaverri J, Lizano M (2019) E6 oncoproteins from high-risk human papillomavirus induce mitochondrial metabolism in a head and neck squamous cell carcinoma model. Biomolecules 9:E351.	LEAK ROUTINE	CIV ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Calabria 2019 Front Neurosci	2019	Calabria Elisa, Scambi Ilaria, Bonafede Roberta, Schiaffino Lorenzo, Peroni Daniele, Potrich Valentina, Capelli Carlo, Schena Federico, Mariotti Raffaella (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an in vitro model of ALS. Front Neurosci 13:1070.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Nervous system
Gonzalez-Mariscal 2019 FASEB J	2019	González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Jansen 2019 Am J Physiol Heart Circ Physiol	2019	Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Heart
Pharaoh 2019 Mol Neurobiol	2019	Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue Isolated mitochondria Intact cells	Mouse	Skeletal muscle Nervous system Fat
Teh 2019 Mol Cancer Ther	2019	Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.	LEAK ROUTINE OXPHOS ET	N S DQ ROX	Intact cells Permeabilized cells Permeabilized tissue	Human Mouse	Other cell lines
Dlaskova 2019 Biochim Biophys Acta Bioenerg	2019	Dlasková A, Špaček T, Engstová H, Špačková J, Schröfel A, Holendová B, Smolková K, Plecitá-Hlavatá L, Ježek P (2019) Mitochondrial cristae narrowing upon higher 2-oxoglutarate load. Biochim Biophys Acta Bioenerg 1860:659-78.	LEAK ET	N ROX	Intact cells	Human	Liver
Shrum 2019 Biomolecules	2019	Shrum S, Rusch NJ, MacMillan-Crow LA (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury in vitro. Biomolecules 9:E825.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Rat	Kidney
Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol	2019	Johansen JL, Esbaugh AJ (2019) Oil-induced responses of cardiac and red muscle mitochondria in red drum (Sciaenops ocellatus). Comp Biochem Physiol C Toxicol Pharmacol 219:35-41.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Fishes	Heart Skeletal muscle
Zhang 2019 Biochem Biophys Res Commun	2019	Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Liver
Krycer 2019 J Biol Chem	2019	Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE (2019) Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes. J Biol Chem 295:99-110.	LEAK ET	ROX	Intact cells	Rat	Fat
Mann 2019 Oncogene	2019	Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX F	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Itkis 2019 Mitochondrion	2019	Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17.	LEAK ROUTINE OXPHOS ET	N CIV NS ROX	Intact cells Permeabilized cells	Human	Fibroblast
Gustafson 2019 PLoS One	2019	Gustafson MA, McCormick EM, Perera L, Longley MJ, Bai R, Kong J, Dulik M, Shen L, Goldstein AC, McCormack SE, Laskin BL, Leroy BP, Ortiz-Gonzalez XR, Ellington MG, Copeland WC, Falk MJ (2019) Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes. PLoS One 14:e0221829.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast Lymphocyte
Tyrrell 2019 Circ Res	2019	Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314.	OXPHOS ET	N S NS ROX		Mouse	Endothelial;epithelial;mesothelial cell
Courtes 2019 Biomed Pharmacother	2019	Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46.	OXPHOS LEAK	N S NS ROX	Isolated mitochondria	Rat	Liver
Cikankova 2019 Naunyn Schmiedebergs Arch Pharmacol	2019	Cikánková T, Fišar Z, Bakhouche Y, Ľupták M, Hroudová J (2019) In vitro effects of antipsychotics on mitochondrial respiration. Naunyn Schmiedebergs Arch Pharmacol 392:1209-23.	OXPHOS	N S ROX	Isolated mitochondria	Pig	Nervous system
Moscheni 2019 Cancers (Basel)	2019	Moscheni C, Malucelli E, Castiglioni S, Procopio A, De Palma C, Sorrentino A, Sartori P, Locatelli L, Pereiro E, Maier JA, Iotti S (2019) 3D quantitative and ultrastructural analysis of mitochondria in a model of doxorubicin sensitive and resistant human colon carcinoma cells. Cancers (Basel) 11:E1254.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Zhao 2019 Pharmacol Res	2019	Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J (2019) MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res 146:104276.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Liver Other cell lines
Nunes 2019 Oxid Med Cell Longev	2019	Nunes MEM, Schimith LE, da Costa-Silva DG, Lopes AR, Leandro LP, Martins IK, de Mello RS, Hartmann DD, de Carvalho NR, Carvalho da Rosa P, Trevisan R, Di Giulio RT, Posser T, Franco JL (2019) Acute exposure to permethrin modulates behavioral functions, redox, and bioenergetics parameters and induces DNA damage and cell death in larval zebrafish. Oxid Med Cell Longev 2019:9149203.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Homogenate	Zebrafish
Garcia-Roche 2019 PLoS One	2019	García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780.	LEAK OXPHOS ET	N S NS ROX	Intact cells	Bovines	Liver
Rodinova 2019 Dis Model Mech	2019	Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.	LEAK OXPHOS ET	N S CIV ROX	Isolated mitochondria	Pig	Skeletal muscle
Isei 2019 Free Radic Biol Med	2019	Isei MO, Kamunde C (2019) Effects of copper and temperature on heart mitochondrial hydrogen peroxide production. Free Radic Biol Med 147:114-28.		N S ROX	Isolated mitochondria	Fishes	Heart
De Moura Escobar 2019 Toxicol In Vitro	2019	de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro 61:104640.	LEAK OXPHOS	N S ROX	Permeabilized cells	Human	Neuroblastoma
Lauridsen 2019 Mitochondrion	2019	Lauridsen PE, Rasmussen LJ, Desler C (2019) Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. Mitochondrion 47:47-53.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Berru 2019 Sci Rep	2019	Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE (2019) Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics. Sci Rep 9:15547.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Rutai 2019 Shock	2019	Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95.	LEAK OXPHOS	N S ROX	Homogenate	Rat	Liver
Zhao 2019 Basic Res Cardiol	2019	Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Rat	Heart Fibroblast
MiPNet12.01 Suppl T-issue	2018-11-18	MitoPathways at the Q-junction: mouse skeletal muscle fibers.	LEAK ROUTINE ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Wilmanns 2018 Mol Metab	2018	Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW (2018) Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Mol Metab 20:102-14.	LEAK OXPHOS ET	F N NS ROX	Permeabilized tissue	Mouse	Heart
Monaco 2018b Diabetologia	2018	Monaco CMF, Hughes MC, Ramos SV, Varah NE, Lamberz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ, Perry CGR (2018) Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia 61:1411-23.	OXPHOS	N S Gp NS ROX	Permeabilized tissue	Human	Skeletal muscle
Boeck 2018 Psychoneuroendocrinology	2018	Boeck C, Gumpp AM, Calzia E, Radermacher P, Waller C, Karabatsiakis A, Kolassa IT (2018) The association between cortisol, oxytocin, and immune cell mitochondrial oxygen consumption in postpartum women with childhood maltreatment. Psychoneuroendocrinology 96:69-77.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Brunetta 2018 Exp Physiol	2018	Brunetta HS, de Paula GC, de Oliveira J, Martins EL, Dos Santos GJ, Filho AG, Rafacho A, de Bem AF, Nunes EA (2018) Decrement in resting and insulin-stimulated soleus muscle mitochondrial respiration is an early event in diet-induced obesity in mice. Exp Physiol 104:306-21.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Mavroudis 2018 Eur J Cardiothorac Surg	2018	Mavroudis CD, Karlsson M, Ko T, Hefti M, Gentile JI, Morgan RW, Plyler R, Mensah-Brown KG, Boorady TW, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Nicolson SC, Spray TL, Sutton RM, Berg RA, Licht DJ, Gaynor JW, Kilbaugh TJ (2018) Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine. Eur J Cardiothorac Surg 54:162-68.	LEAK ET OXPHOS	N S CIV NS ROX	Homogenate	Pig	Nervous system
Logan 2018 Thesis	2018	Logan C (2018) Nitrate and nitrite differentially affect respiration in zebrafish during exercise. Honors Baccalaureate of Science in Nutrition p44.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Zebrafish	Skeletal muscle
Pardo 2018 FASEB J	2018	Pardo R, Vilà M, Cervela L, de Marco M, Gama-Pérez P, González-Franquesa A, Statuto L, Vilallonga R, Simó R, Garcia-Roves PM, Villena JA (2018) Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue. FASEB J 33:2343-58.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Fat
Sirsat 2018 Comp Biochem Physiol A Mol Integr Physiol	2018	Sirsat SKG, Dzialowski EM (2018) Ontogeny of skeletal and cardiac muscle mitochondria oxygen fluxes in two breeds of chicken. Comp Biochem Physiol A Mol Integr Physiol 215:20-7.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Birds	Heart Skeletal muscle
Magnifico 2018 Oxid Med Cell Longev	2018	Magnifico MC, Xhani M, Popov M, Saso L, Sarti P, Arese M (2018) Nonylphenol and octylphenol differently affect cell redox balance by modulating the nitric oxide signaling. Oxid Med Cell Longev 2018:1684827.	ROUTINE OXPHOS	N S CIV ROX	Permeabilized cells Intact cells	Human	Liver Other cell lines
Paech 2018b Toxicology	2018	Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology 409:13-23.	LEAK OXPHOS ET	N S DQ CIV ROX NS	Isolated mitochondria	Mouse	Liver
Reyes 2018 EMBO Mol Med	2018	Reyes A, Melchionda L, Burlina A, Robinson AJ, Ghezzi D, Zeviani M (2018) Mutations in TIMM50 compromise cell survival in OxPhos-dependent metabolic conditions. EMBO Mol Med 10:e8698.	LEAK ET	ROX	Intact cells	Human	Fibroblast
Hsiao 2018 Anal Biochem	2018	Hsiao CP, Hoppel C (2018) Analyzing mitochondrial function in human peripheral blood mononuclear cells. Anal Biochem 549:12-20.	OXPHOS ET	F N S DQ CIV NS ROX	Intact cells	Human	Blood cells
Rajasekaran 2018 FASEB J	2018	Rajasekaran R, Felser A, Nuoffer JM, Dufour JF, St-Pierre MV (2018) The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism. FASEB J 32:5143-61.	LEAK OXPHOS ET	N S CIV ROX	Isolated mitochondria	Mouse	Liver
Reutzel 2018 Oxid Med Cell Longev	2018	Reutzel M, Grewal R, Silaidos C, Zotzel J, Marx S, Tretzel J, Eckert GP (2018) Effects of long-term treatment with a blend of highly purified olive secoiridoids on cognition and brain ATP levels in aged NMRI mice. Oxid Med Cell Longev 2018:4070935.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Manoharan 2018 Thesis	2018	Manoharan N (2018) Characterization of mitochondrial respiration in atlantic salmon (Salmo salar) fed with glutamate and succinate enhanced diet. Master's Thesis 52.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Fishes	Heart Liver
Salin 2018 Funct Ecol	2018	Salin K, Villasevil EM, Anderson GJ, Auer SK, Selman C, Hartley RC, Mullen W, Chinopoulos C, Metcalfe NB (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Funct Ecol DOI: 10.1111/1365-2435.13125.	LEAK OXPHOS	CIV NS ROX	Homogenate	Fishes	Liver
Tsuda 2018 J Cachexia Sarcopenia Muscle	2018	Tsuda M, Fukushima A, Matsumoto J, Takada S, Kakutani N, Nambu H, Yamanashi K, Furihata T, Yokota T, Okita K, Kinugawa S, Anzai T (2018) Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure. J Cachexia Sarcopenia Muscle 9:844-59.	OXPHOS LEAK	F N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Giordano 2018 Am J Respir Cell Mol Biol	2018	Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M (2018) Alternative oxidase attenuates cigarette smoke-induced lung dysfunction and tissue damage. Am J Respir Cell Mol Biol 60:515-22.	OXPHOS	N S CIV ROX	Permeabilized cells	Mouse	Fibroblast
Rubio-Villena 2018 Hum Mol Genet	2018	Rubio-Villena C, Viana R, Bonet J, Garcia-Gimeno MA, Casado M, Heredia M, Sanz P (2018) Astrocytes: new players in progressive myoclonus epilepsy of Lafora type. Hum Mol Genet 27:1290-1300.	LEAK ROUTINE ET	ROX		Mouse	Nervous system
Barca 2018 Hum Mol Genet	2018	Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12.	LEAK ROUTINE OXPHOS ET	F N S DQ NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Merz 2018 Intensive Care Med Exp	2018	Merz T, Wepler M, Nußbaum B, Vogt J, Calzia E, Wang R, Szabo C, Radermacher P, McCook O (2018) Cystathionine-γ-lyase expression is associated with mitochondrial respiration during sepsis-induced acute kidney injury in swine with atherosclerosis. Intensive Care Med Exp 6:43.	LEAK OXPHOS ET	F N S NS ROX	Homogenate	Pig	Kidney
Uribe-Alvarez 2018 Microbiologyopen	2018	Uribe-Alvarez C, Chiquete-Félix N, Morales-García L, Bohórquez-Hernández A, Delgado-Buenrostro NL, Vaca L, Peña A, Uribe-Carvajal S (2018) Wolbachia pipientis grows in Saccharomyces cerevisiae evoking early death of the host and deregulation of mitochondrial metabolism. Microbiologyopen 8:e00675.	OXPHOS ET	CIV ROX N NS	Isolated mitochondria	Saccharomyces cerevisiae
Thrush 2018 Int J Obes (Lond)	2018	Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack R, Al-Dirbashi OY, Dent R, McPherson R, Harper ME (2018) Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism. Int J Obes (Lond) 42:353-62.	LEAK OXPHOS ET	F N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Scheiber 2018 J Cardiovasc Transl Res	2018	Scheiber D, Zweck E, Jelenik T, Horn P, Albermann S, Masyuk M, Boeken U, Saeed D, Kelm M Roden M, Szendroedi J, Westenfeld R (2018) Reduced myocardial mitochondrial ROS production in mechanically unloaded hearts. J Cardiovasc Transl Res 12:107-15.	LEAK OXPHOS ET	F N NS ROX	Permeabilized tissue	Human	Heart
Burtscher 2018 Front Mol Neurosci	2018	Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C (2018) Proenkephalin derived peptides are involved in the modulation of mitochondrial respiratory control during epileptogenesis. Front Mol Neurosci doi:10.3389/fnmol.2018.00351.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Pamenter 2018 PLoS One	2018	Pamenter ME, Lau GY, Richards JG (2018) Effects of cold on murine brain mitochondrial function. PLoS One 13:e0208453.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized tissue	Mouse	Nervous system
JanssenDuijghuijsen 2018 Thesis	2018	JanssenDuijghuijsen LM (2018) Good, Bad, or Risky? Intestinal permeability to protein: Human and in vitro studies. Doctoral Thesis p154.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Monzio Compagnoni 2018 Biochim Biophys Acta Mol Basis Dis	2018	Monzio Compagnoni G, Kleiner G, Bordoni A, Fortunato F, Ronchi D, Salani S, Guida M, Corti C, Pichler I, Bergamini C, Fato R, Pellecchia MT, Vallelunga A, Del Sorbo F, Elia A, Reale C, Garavaglia B, Mora G, Albanese A, Cogiamanian F, Ardolino G, Bresolin N, Corti S, Comi GP, Quinzii CM, Di Fonzo A (2018) Mitochondrial dysfunction in fibroblasts of multiple system atrophy. Biochim Biophys Acta Mol Basis Dis 1864:3588-97.	OXPHOS ET ROUTINE	N S NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Farias 2018 Int J Biol Macromol	2018	Farias CLA, Martinez GR, Cadena SMSC, Mercê ALR, de Oliveira Petkowicz CL, Noleto GR (2018) Cytotoxicity of xyloglucan from Copaifera langsdorffii and its complex with oxovanadium (IV/V) on B16F10 cells. Int J Biol Macromol 121:1019-28.	LEAK ET ROUTINE	ROX	Intact cells	Mouse	Endothelial;epithelial;mesothelial cell
Leckey 2018 FASEB J	2018	Leckey JJ, Hoffman NJ, Parr EB, Devlin BL, Trewin AJ, Stepto NK, Morton JP, Burke LM, Hawley JA (2018) High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J 32:2979-91.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Weber 2018 Int J Mol Sci	2018	Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE (2018) Succinate accumulation is associated with a shift of mitochondrial respiratory control and HIF-1α upregulation in PTEN negative prostate cancer cells. Int J Mol Sci 19:2129.	ROUTINE OXPHOS ET	F N S NS Other combinations ROX	Intact cells Permeabilized cells	Human	Genital
Reguis Yadao 2018 Thesis	2018	Reguis Yadao DR (2018) Smooth muscle cell mitochondrial respiration – effects of aerobic training and type I diabetes. Master's Thesis 71.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Other cell lines
Tai 2018 Acta Pharm Sin B	2018	Tai Y, Li L, Peng X, Zhu J, Mao X, Qin N, Ma M, Huo R, Bai Y, Dong D (2018) Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells. Acta Pharm Sin B 8:909-18.	LEAK ET	ROX	Intact cells	Mouse	Endothelial;epithelial;mesothelial cell
Ryan 2018 JCI Insight	2018	Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM (2018) Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants. JCI Insight 3:123235.	OXPHOS LEAK	N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Stepanova 2018 J Neurochem	2018	Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A (2018) The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem 148:731-45.	LEAK OXPHOS	N S Gp NS ROX	Isolated mitochondria	Mouse	Nervous system
Zhuang 2018 Thesis	2018	Zhuang Y (2018) Potential application of alternative oxidase (AOX) in neurodegenerative diseases. Master's Thesis p71.	OXPHOS	N S CIV ROX	Isolated mitochondria	Mouse	Nervous system
Furlanetto 2018 Physiol Plant	2018	Furlanetto ALDM, Cadena SMSC, Martinez GR, Ferrando B, Stevnsner T, Møller IM (2018) Short-term high temperature treatment reduces viability and inhibits respiration and DNA repair enzymes in Araucaria angustifolia cells. Physiol Plant 166:513-24.	ET ROUTINE	N CIV ROX	Intact cells	Plants
Bialas 2018 Int J Chron Obstruct Pulmon Dis	2018	Białas AJ, Siewiera K, Watała C, Rybicka A, Grobelski B, Kośmider L, Kurek J, Miłkowska-Dymanowska J, Piotrowski WJ, Górski P (2018) Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs – a pilot study. Int J Chron Obstruct Pulmon Dis 13:3707—17 .	LEAK ROUTINE ET	ROX	Intact cells	Guinea pig	Platelet
Blunsom 2018 Biochim Biophys Acta	2018	Blunsom NJ, Gomez-Espinosa E, Ashlin TG, Cockcroft S (2018) Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1. Biochim Biophys Acta 1863:284-98.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Komlodi 2018 Methods Mol Biol	2018	Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized cells Permeabilized tissue	Human Mouse	Skeletal muscle HEK
Eimre 2018 Oxid Med Cell Longev	2018	Eimre M, Paju K, Peet N, Kadaja L, Tarrend M, Kasvandik S, Seppet J, Ivask M, Orlova E, Kõks S (2018) Increased mitochondrial protein levels and bioenergetics in the musculus rectus femoris of Wfs1-deficient mice. Oxid Med Cell Longev 2018:3175313.	OXPHOS LEAK	N S CIV ROX	Permeabilized tissue	Mouse	Skeletal muscle
Silva 2018 Nat Cell Biol	2018	Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, Pérez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-Gené S, Raught B, González-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH (2018) EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Nat Cell Biol 20:162-74.	OXPHOS ET	N S NS ROX	Permeabilized tissue		Islet cell;pancreas;thymus
Durand 2018 Blood Purif	2018	Durand PY, Nicco C, Serteyn D, Attaf D, Edeas M (2018) Microbiota quality and mitochondrial activity link with occurrence of muscle cramps in hemodialysis patients using citrate dialysate: a pilot study. Blood Purif 46:301-8.	LEAK ROUTINE OXPHOS ET	S ROX	Intact cells	Human	Platelet Blood cells
Simard 2018 J Vis Exp	2018	Simard CJ, Pelletier G, Boudreau LH, Hebert-Chatelain E, Pichaud N (2018) Measurement of mitochondrial oxygen consumption in permeabilized fibers of Drosophila using minimal amounts of tissue. J Vis Exp 134.	LEAK OXPHOS	N Gp CIV NS ROX	Permeabilized tissue	Drosophila
Haschka 2018 Mov Disord	2018	Haschka D, Volani C, Stefani A, Tymoszuk P, Mitterling T, Holzknecht E, Heidbreder A, Coassin S, Sumbalova Z, Seifert M, Dichtl S, Theurl I, Gnaiger E, Kronenberg F, Frauscher B, Högl B, Weiss G (2018) Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome. Mov Disord 34:114-23.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Doerrier 2018 Methods Mol Biol	2018	Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells	Human Mouse Rat Saccharomyces cerevisiae	Heart Skeletal muscle Endothelial;epithelial;mesothelial cell Blood cells HEK Platelet
Casal 2018 J Anim Sci	2018	Casal A, Garcia-Roche M, Navajas EA, Cassina A, Carriquiry M (2018) Hepatic mitochondrial function in Hereford steers with divergent residual feed intake phenotypes. J Anim Sci 96:4431-43.	LEAK OXPHOS ET	N S ROX	Intact cells	Bovines	Liver
Laouafa 2018 Adv Exp Med Biol	2018	Laouafa S, Roussel D, Marcouiller F, Soliz J, Bairam A, Joseph V (2018) Role of estradiol receptor beta (ERβ) on arterial pressure, respiratory chemoreflex and mitochondrial function in young and aged female mice. Adv Exp Med Biol 1071:115-27.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized tissue	Mouse	Nervous system
Champigny 2018 Mar Drugs	2018	Champigny CM, Cormier RPJ, Simard CJ, St-Coeur PD, Fortin S, Pichaud N (2018) Omega-3 monoacylglyceride effects on longevity, mitochondrial metabolism and oxidative stress: insights from Drosophila melanogaster. Mar Drugs 16:E453.	LEAK OXPHOS ET	N S NS ROX Gp	Permeabilized tissue	Drosophila
Mayer 2018 Endocrinology	2018	Mayer AL, Zhang Y, Feng EH, Higgins CB, Adenekan O, Pietka TA, Beatty WL, DeBosch BJ (2018) Enhanced hepatic PPARα activity links GLUT8 deficiency to augmented peripheral fasting responses in male mice. Endocrinology 159:2110-26.	OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Liver
Martins 2018 Oxid Med Cell Longev	2018	Martins IK, de Carvalho NR, Macedo GE, Rodrigues NR, Ziech CC, Vinadé L, Filho VMB, Menezes IA, Franco J, Posser T (2018) Anacardium microcarpum promotes neuroprotection dependently of AKT and ERK phosphorylation but does not prevent mitochondrial damage by 6-OHDA. Oxid Med Cell Longev 2018:2131895.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Chicken	Nervous system
Setz 2018 Hear Res	2018	Setz C, Benischke AS, Pinho Ferreira Bento AC, Brand Y, Levano S, Paech F, Leitmeyer K, Bodmer D (2018) Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti. Hear Res 361:52-65.	OXPHOS ET	F N S NS ROX	Permeabilized cells	Mouse	Other cell lines
Yang 2018 Cell Death Dis	2018	Yang F, Wu R, Jiang Z, Chen J, Nan J, Su S, Zhang N, Wang C, Zhao J, Ni C, Wang Y, Hu W, Zeng Z, Zhu K, Liu X, Hu X, Zhu W, Yu H, Huang J, Wang J (2018) Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death Dis 9:556.		N S CIV NS ROX	Intact cells	Mouse
Trewin 2018 Am J Physiol Regul Integr Comp Physiol	2018	Trewin AJ, Parker L, Shaw CS, Hiam D, Garnham AP, Levinger I, McConell GK, Stepto NK (2018) Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration and cell signaling as endurance exercise even with less work. Am J Physiol Regul Integr Comp Physiol 315:R1003-R1016.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Pless-Petig 2018 Cell Transplant	2018	Pless-Petig G, Walter B, Bienholz A, Rauen U (2018) Mitochondrial impairment as a key factor for the lack of attachment after cold storage of hepatocyte suspensions. Cell Transplant 26:1855-67.		ROX	Intact cells	Rat	Liver
Hafen 2018 J Appl Physiol (1985)	2018	Hafen PS, Preece CN, Sorensen JR, Hancock CR, Hyldahl RD (2018) Repeated exposure to heat stress induces mitochondrial adaptation in human skeletal muscle. J Appl Physiol (1985) 125:1447-55.	OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Zhang 2018 Aging Dis	2018	Zhang L, Hao J, Zheng Y, Su R, Liao Y, Gong X, Liu L, Wang X (2018) Fucoidan protects dopaminergic neurons by enhancing the mitochondrial function in a rotenone-induced rat model of Parkinson’s disease. Aging Dis 9:590-604.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue Homogenate	Rat	Nervous system
Tetri 2018 Front Physiol	2018	Tetri LH, Diffee GM, Barton GP, Braun RK, Yoder HE, Haraldsdottir K, Eldridge MW, Goss KN (2018) Sex-specific skeletal muscle fatigability and decreased mitochondrial oxidative capacity in adult rats exposed to postnatal hyperoxia. Front Physiol 9:326.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized tissue	Rat	Skeletal muscle
Manakov 2018 J Physiol Biochem	2018	Manakov D, Kolar D, Zurmanova J, Pravenec M, Novotny J (2018) Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36. J Physiol Biochem 74:479-89.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Rat	Heart
Becker 2018 EMBO Rep	2018	Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A (2018) CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep 19. pii: e45126.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Liver Fat
Song 2018 J Cell Physiol	2018	Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z (2018) Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo. J Cell Physiol 234:777-88.	LEAK ET	ROX	Intact cells	Human	Islet cell;pancreas;thymus
Niu 2018 Cancer Metab	2018	Niu X, Chen YJ, Crawford PA, Patti GJ (2018) Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells. Cancer Metab 6:19.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Human	HeLa
Wu 2018 Adv Sci	2018	Wu S, Zhang A, Li S, Chatterjee S, Qi R, Segura-Ibarra V, Ferrari M, Gupte A, Blanco E, Hamilton DJ (2018) Polymer functionalization of isolated mitochondria for cellular transplantation and metabolic phenotype alteration. Adv Sci 1700530.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Liver
Kong 2018 Proteomics	2018	Kong D, Tian X, Li Y*, Zhang S, Cheng Y, Huo L, Ma H, Yang Z, Ren L, Zhang M, Zhang W (2018) Revealing the inhibitory effect of ginseng on mitochondrial respiration through synaptosomal proteomics. Proteomics 18:e1700354.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Bjoerndal 2018 Nutr Metab (Lond)	2018	Bjørndal B, Alterås EK, Lindquist C, Svardal A, Skorve J, Berge RK (2018) Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice. Nutr Metab (Lond) 15:10.	OXPHOS ET	F N ROX	Homogenate	Mouse	Liver
Pileggi 2018 Free Radic Biol Med	2018	Pileggi CA, Hedges CP, D'Souza RF, Durainayagam BR, Markworth JF, Hickey AJR, Mitchell CJ, Cameron-Smith D (2018) Exercise recovery increases skeletal muscle H2O2 emission and mitochondrial respiratory capacity following two-weeks of limb immobilization. Free Radic Biol Med 124:241-8.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Sokolov 2018 Mitochondrion	2018	Sokolov EP, Sokolova IM (2018) Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45:29-37.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Molluscs	Lung;gill
Ounpuu 2018 Biochem Cell Biol	2018	Ounpuu L, Truu L, Shevchuk I, Chekulayev V, Klepinin A, Koit A, Tepp K, Puurand M, Rebane-Klemm E, Käämbre T (2018) Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochem Cell Biol [Epub ahead of print].	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Bombaca 2018 Free Radic Biol Med	2018	Bombaça ACS, Viana PG, Santos ACC, Silva TL, Rodrigues ABM, Guimarães ACR, Goulart MOF, Da Silva Júnior EN, Menna-Barreto RFS (2018) Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles. Free Radic Biol Med 130:408-18.	ROUTINE	ROX	Intact organism	Protists
Braz-Mota 2018 Sci Total Environ	2018	Braz-Mota S, Campos DF, MacCormack TJ, Duarte RM, Val AL, Almeida-Val VMF (2018) Mechanisms of toxic action of copper and copper nanoparticles in two Amazon fish species: Dwarf cichlid (Apistogramma agassizii) and cardinal tetra (Paracheirodon axelrodi). Sci Total Environ 630:1168-80.	LEAK OXPHOS ET	N NS ROX		Fishes	Lung;gill
Burney 2018 Thesis	2018	Burney E (2018) Characterization of mitochondrial metabolism in L6 rat myoblasts. Bachelor's Thesis p50.	LEAK ROUTINE OXPHOS ET	F N S Gp NS Other combinations ROX	Permeabilized cells Intact cells	Rat	Other cell lines
Friederich 2018 Nat Commun	2018	Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, González C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B Jr, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernández-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK (2018) Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Nat Commun 9:4065.	ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human Fungi	Fibroblast
Jang 2018 J Med Toxicol	2018	Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM (2018) Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. J Med Toxicol 14:144-51.	LEAK ROUTINE OXPHOS ET	N S Gp CIV NS ROX	Intact cells Permeabilized cells	Human	Blood cells
Tarpey 2018 Skelet Muscle	2018	Tarpey MD, Amorese AJ, Balestrieri NP, Ryan TE, Schmidt CA, McClung JM, Spangenburg EE (2018) Characterization and utilization of the flexor digitorum brevis for assessing skeletal muscle function. Skelet Muscle 8:14.	OXPHOS	N S CIV NS ROX		Mouse	Skeletal muscle
Sims 2018 JCI Insight	2018	Sims CA, Guan Y, Mukherjee S, Singh K, Botolin P, Davila A Jr, Baur JA (2018) Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock. JCI Insight 3:120182.	OXPHOS	N S CIV ROX	Permeabilized cells Isolated mitochondria	Rat	Liver Kidney
Groennebaek 2018 Front Physiol	2018	Groennebaek T, Jespersen NR, Jakobsgaard JE, Sieljacks P, Wang J, Rindom E, Musci RV, Bøtker HE, Hamilton KL, Miller BF, de Paoli FV, Vissing K (2018) Skeletal muscle mitochondrial protein synthesis and respiration increase with low-load blood flow restricted as well as high-load resistance training. Front Physiol 9:1796.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Krug 2018 Thesis	2018	Krug KP (2018) Adaptation of metabolism and respiratory chain functions in pulmonary arterial vascular muscle cells under chronic hypoxia: especially considering the cytochrome c oxidase subunit 4 isoform 2. Doctoral Dissertation 136.	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Intact cells Permeabilized cells	Rat	Other cell lines
Woodman 2018 FASEB J	2018	Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2018) Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver. FASEB J 32:3254-63.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Rat	Liver Kidney
Boeck 2018 Sci Rep	2018	Boeck C, Salinas-Manrique J, Calzia E, Radermacher P, von Arnim CAF, Dietrich DE, Kolassa IT, Karabatsiakis A (2018) Targeting the association between telomere length and immunocellular bioenergetics in female patients with Major Depressive Disorder. Sci Rep 8:9419.	LEAK ROUTINE ET	N ROX	Intact cells	Human	Blood cells
Guitart-Mampel 2018 Biochim Biophys Acta	2018	Guitart-Mampel M, Gonzalez-Tendero A, Niñerola S, Morén C, Catalán-Garcia M, González-Casacuberta I, Juárez-Flores DL, Ugarteburu O, Matalonga L, Cascajo MV, Tort F, Cortés A, Tobias E, Milisenda JC, Grau JM, Crispi F, Gratacós E, Garrabou G, Cardellach F (2018) Cardiac and placental mitochondrial characterization in a rabbit model of intrauterine growth restriction. Biochim Biophys Acta 1862:1157-67.		N ROX	Permeabilized tissue	Rabbit	Heart Genital
Klepinin 2018 J Bioenerg Biomembr	2018	Klepinin A, Ounpuu L, Mado K, Truu L, Chekulayev V, Puurand M, Shevchuk I, Tepp K, Planken A, Kaambre T (2018) The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins. J Bioenerg Biomembr 50:339-54.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Heart Neuroblastoma
Fischer 2018 BMC Musculoskelet Disord	2018	Fischer MJ, Horvath G, Krismer M, Gnaiger E, Goebel G, Pesta DH (2018) Evaluation of mitochondrial function in chronic myofascial trigger points - a prospective cohort pilot study using high-resolution respirometry. BMC Musculoskelet Disord 19:388.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Lobo-Jarne 2018 Cell Rep	2018	Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A (2018) Human COX7A2L regulates complex III biogenesis and promotes supercomplex organization remodeling without affecting mitochondrial bioenergetics. Cell Rep 25:1786-99.	LEAK OXPHOS ET	N S NS ROX Gp	Permeabilized cells	Human	HEK Other cell lines
Dejos 2018 Sci Rep	2018	Dejos C, Kuny S, Han WH, Capel H, Lemieux H, Sauvé Y (2018) Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3). Sci Rep 8:5944.	OXPHOS	N S CIV NS ROX	Homogenate	Mouse	Endothelial;epithelial;mesothelial cell
Goncalves 2018 Neurotoxicology	2018	Gonçalves DF, Courtes AA, Hartmann DD, da Rosa PC, Oliveira DM, Soares FAA, Dalla Corte CL (2018) 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. Neurotoxicology 70:1-11.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Nervous system
Oemer 2018 Proc Nat Acad Sci U S A	2018	Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Intact cells Permeabilized cells	Human	HeLa
Robb 2018 J Biol Chem	2018	Robb EL, Hall AR, Prime TA, Eaton S, Szibor M, Viscomi C, James AM, Murphy MP (2018) Control of mitochondrial superoxide production by reverse electron transport at complex I. J Biol Chem 293:9869-79.	ET	N S ROX	Isolated mitochondria	Rat	Heart
Nielsen 2018 Neurosci Lett	2018	Nielsen B, Cejvanovic V, Wörtwein G, Hansen AR, Marstal KK, Weimann A, Bjerring PN, Dela F, Poulsen HE, Jørgensen MB (2018) Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. Neurosci Lett 690:1-5.	LEAK OXPHOS ET	N NS ROX S	Homogenate	Rat	Nervous system
Chen 2018 iScience	2018	Chen YC, Cheng TH, Lin WL, Chen CL, Yang WY, Blackstone C, Chang CR (2018) Srv2 Is a pro-fission factor that modulates yeast mitochondrial morphology and respiration by regulating actin assembly. iScience 11:305-17.	LEAK ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Goncalves 2018 Life Sci	2018	Gonçalves DF, de Carvalho NR, Leite MB, Courtes AA, Hartmann DD, Stefanello ST, da Silva IK, Franco JL, Soares FAA, Dalla Corte CL (2018) Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics. Life Sci 193:234-41.	LEAK OXPHOS	N S NS ROX	Homogenate	Mouse	Liver
Coleman 2018 Sci Rep	2018	Coleman V, Sa-Nguanmoo P, Koenig J, Schulz TJ, Grune T, Klaus S, Kipp AP, Ost M (2018) Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Sci Rep 8:2446.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Chou 2018 Int J Cardiol	2018	Chou CH, Fu TC, Tsai HH, Hsu CC, Wang CH, Wang JS (2018) High-intensity interval training enhances mitochondrial bioenergetics of platelets in patients with heart failure. Int J Cardiol 274:214-20.	LEAK ROUTINE OXPHOS ET	F N S NS ROX	Intact cells Permeabilized cells	Human	Platelet Blood cells
Ko 2018 Pflugers Arch	2018	Ko TH, Marquez JC, Kim HK, Jeong SH, Lee S, Youm JB, Song IS, Seo DY, Kim HJ, Won DN, Cho KI, Choi MG, Rhee BD, Ko KS, Kim N, Won JC, Han J (2018) Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts. Pflugers Arch 470:263-75.	LEAK OXPHOS	N ROX	Isolated mitochondria	Rat	Heart
Machado-Neto 2018 Cell Death Dis	2018	Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F (2018) Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. Cell Death Dis 9:311.	LEAK ROUTINE ET	ROX	Intact cells	Human Mouse	Other cell lines
Karlsson 2018 J Neurotrauma	2018	Karlsson M, Pukenas B, Chawla S, Ehinger JK, Plyler R, Stolow M, Gabello M, Hugerth M, Elmér E, Hansson MJ, Margulies S, Kilbaugh T (2018) Neuroprotective effects of cyclosporine in a porcine pre-clinical trial of focal traumatic brain injury. J Neurotrauma [Epub ahead of print].	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Pig	Nervous system
Teulier 2018 J Fish Biol	2018	Teulier L, Guillard L, Leon C, Romestaing C, Voituron Y (2018) Consequences of electroshock-induced narcosis in fish muscle: from mitochondria to swim performance. J Fish Biol 92:1805-18.	OXPHOS ET	N NS ROX	Intact cells	Fishes Zebrafish	Skeletal muscle
Lee 2018 Reprod Sci	2018	Lee HC, Lin SC, Wu MH, Tsai SJ (2018) Induction of pyruvate dehydrogenase kinase 1 by hypoxia alters cellular metabolism and inhibits apoptosis in endometriotic stromal cells. Reprod Sci 26:734-44.	LEAK ROUTINE	ROX	Intact cells	Human	Genital
Thompson 2018 EMBO Mol Med	2018	Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW (2018) OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Mol Med 10:e9060.	LEAK OXPHOS	N CIV ROX Gp Other combinations	Homogenate	Drosophila
Christen 2018 Free Radic Biol Med	2018	Christen F, Desrosiers V, Dupont-Cyr BA, Vandenberg GW, Le François NR, Tardif JC, Dufresne F, Lamarre SG, Blier PU (2018) Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production. Free Radic Biol Med 116:11-8.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Fishes	Heart
Martinez 2018 Arch Biochem Biophys	2018	Martínez JH, Fuentes F, Vanasco V, Alvarez S, Alaimo A, Cassina A, Coluccio Leskow F, Velazquez F (2018) Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment. Arch Biochem Biophys 651:1-12.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Rat	Nervous system
Kahancova 2018 FEBS Lett	2018	Kahancova A, Sklenar F, Jezek P, Dlaskova A (2018) Regulation of glucose-stimulated insulin secretion by ATPase Inhibitory Factor 1 (IF1). FEBS Lett 592:999-1009.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Other cell lines
Salin 2018 Integr Comp Biol	2018	Salin K, Villasevil EM, Anderson GJ, Selman C, Chinopoulos C, Metcalfe NB (2018) The RCR and ATP/O indices can give contradictory messages about mitochondrial efficiency. Integr Comp Biol 58:486-94.	LEAK OXPHOS	N S NS ROX	Homogenate	Fishes	Liver
Fox 2018 Thesis	2018	Fox JC (2018) FROST450, a novel microtubule targeting agent: resistance and cross-resistance in an ovarian cancer cell line. Bachelor's Thesis 27.	LEAK OXPHOS ET	N NS ROX	Intact cells	Human	Genital
Kener 2018 J Vis Exp	2018	Kener KB, Munk DJ, Hancock CR, Tessem JS (2018) High-resolution respirometry to measure mitochondrial function of intact beta cells in the presence of natural compounds. J Vis Exp 131.	LEAK ET	ROX	Intact cells		Islet cell;pancreas;thymus
Rundle 2018 Environ Sci Technol	2018	Rundle K, Sharaf M, Stevens D, Kamunde C, Van Den Heuvel MR (2018) Oil sands-derived naphthenic acids are oxidative uncouplers and impair electron transport in isolated mitochondria. Environ Sci Technol 52:10803-11.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Fishes	Liver
Aparicio-Trejo 2018 Free Radic Biol Med	2018	Aparicio-Trejo OE, Reyes-Fermín LM, Briones-Herrera A, Tapia E, León-Contreras JC, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2018) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379-96.	LEAK OXPHOS	N S NS ROX	Intact cells Isolated mitochondria	Rat	Kidney
Zimin 2018 Br J Anaesth	2018	Zimin PI, Woods CB, Kayser EB, Ramirez JM, Morgan PG, Sedensky MM (2018) Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I. Br J Anaesth 120:1019-32.	OXPHOS LEAK	N S ROX	Isolated mitochondria	Mouse	Nervous system
Liu 2018 J Periodontol	2018	Liu J, Zeng J, Wang X, Zheng M, Luan Q (2018) P53 mediates lipopolysaccharide-induced inflammation in human gingival fibroblasts. J Periodontol 89:1142-51.	LEAK ET	ROX	Intact cells	Human	Fibroblast
Sant'Anna-Silva 2018 Front Oncol	2018	Sant'Anna-Silva ACB, Santos GC, Campos SPC, Oliveira Gomes AM, Pérez-Valencia JA, Rumjanek FD (2018) Metabolic profile of oral squamous carcinoma cell lines relies on a higher demand of lipid metabolism in metastatic cells. Front Oncol 8:13.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines Fibroblast
Gatterer 2018 J Sports Sci Med	2018	Gatterer H, Menz V, Salazar-Martinez E, Sumbalova Z, Garcia-Souza LF, Cizmarova B, Gnaiger E, Burtscher M (2018) Exercise performance, muscle oxygen extraction and blood cell mitochondrial respiration after repeated-sprint and sprint interval training in hypoxia: a pilot study. J Sports Sci Med 17:339-347.	ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
MacMillan-Crow 2018 Intern Med Rev (Wash D C)	2018	MacMillan-Crow LA, Mayeux PR (2018) Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis. Intern Med Rev (Wash D C) 4.	OXPHOS LEAK	N S ROX	Permeabilized tissue	Mouse	Kidney
Razak 2018 RUMeS	2018	Razak SHA, Hassan H, Hakimi NH, Rani NA, Ibrahim NF, Ngah WZW, Makpol S, Damanhuri MHA, Karim NA, Tan JK (2018) Isolation of mitochondria and measurement of oxygen consumption rate by high-resolution respirometry in rat hippocampus. RUMeS 6:11-18.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Nervous system
Smenes 2018 Interact Cardiovasc Thorac Surg	2018	Smenes BT, Bækkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Høydal M, Wisløff U, Rognmo Ø, Wahba A (2018) Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg 27:95-101.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Heart
Kriel 2018 Sci Rep	2018	Kriel J, Mueller-Nedebock K, Maarman G, Mbizana S, Ojuka E, Klumperman B, Loos B (2018) Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics. Sci Rep 8:10348.	LEAK OXPHOS ET ROUTINE	N ROX	Permeabilized cells	Human	Nervous system Other cell lines
Ejarque 2018 Int J Obes (Lond)	2018	Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S (2018) Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells. Int J Obes (Lond) 43:1256-68.	LEAK ROUTINE ET	CIV ROX	Intact cells	Human	Fat
Lu 2018 Cell Rep	2018	Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Doucet 2018 Mol Pharmacol	2018	Doucet MS, Jougleux JL, Poirier SJ, Cormier M, Leger JL, Surette ME, Pichaud N, Touaibia M, Boudreau LH (2018) Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets. Mol Pharmacol 95:139-50.	LEAK ROUTINE ET	ROX	Intact cells	Human	Platelet Blood cells
Cunatova 2018 Thesis	2018	Čunátová K (2018) The role of tissue specific isoforms of subunit 4 in assembly and function of cytochrome c oxidase. PhD Thesis p107.	LEAK ROUTINE ET	CIV ROX	Intact cells	Human	HEK
Kulkarni 2018 Haematologica	2018	Kulkarni PP, Tiwari A, Singh N, Gautam D, Sonkar VK, Agarwal V, Dash D (2018) Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents. Haematologica 104:806-18.	LEAK ROUTINE ET	ROX	Intact cells	Human	Platelet Blood cells
Rodrigues 2018 Free Radic Biol Med	2018	Rodrigues NR, Macedo GE, Martins IK, Gomes KK, de Carvalho NR, Posser T, Franco JL (2018) Short-term sleep deprivation with exposure to nocturnal light alters mitochondrial bioenergetics in Drosophila. Free Radic Biol Med 120:395-406.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Drosophila
Stepanova 2018 J Cereb Blood Flow Metab	2018	Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A (2018) Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain. J Cereb Blood Flow Metab 39:1790-802.	OXPHOS ET LEAK	N S ROX	Isolated mitochondria	Rat	Nervous system
Hedges 2018 FASEB J	2018	Hedges CP, Bishop DJ, Hickey AJR (2018) Voluntary wheel running prevents the acidosis-induced decrease in skeletal muscle mitochondrial reactive oxygen species emission. FASEB J 33:4996-5004.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Kamunde 2018 Free Radic Biol Med	2018	Kamunde C, Sharaf M, MacDonald N (2018) H2O2 metabolism in liver and heart mitochondria: Low emitting-high scavenging and high emitting-low scavenging systems. Free Radic Biol Med 124:135-48.	LEAK	N ROX	Isolated mitochondria	Fishes	Heart Liver
Houghton 2018 Free Radic Biol Med	2018	Houghton MJ, Kerimi A, Tumova S, Boyle JP, Williamson G (2018) Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells. Free Radic Biol Med 129:296-309.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Zhou 2018 Cell Death Dis	2018	Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H, Lyu J (2018) Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. Cell Death Dis 9:161.	LEAK ROUTINE	ROX	Intact cells	Human	Islet cell;pancreas;thymus Other cell lines
Van der Pluijm 2018 Cardiovasc Res	2018	van der Pluijm I, Burger J, van Heijningen PM, IJpma A, van Vliet N, Milanese C, Schoonderwoerd K, Sluiter W, Ringuette LJ, Dekkers DHW, Que I, Kaijzel EL, Te Riet L, MacFarlane E, Das D, van der Linden R, Vermeij M, Demmers JA, Mastroberardino PG, Davis EC, Yanagisawa H, Dietz H, Kanaar R, Essers J (2018) Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation. Cardiovasc Res 114:1776-93.	OXPHOS	N S NS ROX	Homogenate	Mouse	Skeletal muscle
Rocha 2018 J Physiol Biochem	2018	Rocha C, Koury OH, Scheede-Bergdahl C, Bergdahl A (2018) Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice. J Physiol Biochem 75:65-72.	LEAK OXPHOS ET	F N CIV NS ROX	Permeabilized tissue	Mouse	Heart
Dechandt 2018 Am J Physiol Regul Integr Comp Physiol	2018	Dechandt CR, Vicentini TM, Lanfredi GP, da Silva RMP Jr, Espreafico EM, de Oliveira JAC, Faça VM, Garcia-Cairasco N, Alberici LC (2018) The highly efficient power house in the Wistar Audiogenic Rat (WAR), an epileptic rat strain. Am J Physiol Regul Integr Comp Physiol 316:R243-R254.	LEAK OXPHOS ET	N ROX	Permeabilized tissue Isolated mitochondria	Rat	Heart Skeletal muscle Liver
Petiz 2018 Chem Biol Interact	2018	Petiz LL, Pires ADRA, Echevarria A, Rodrigues-Santos CE, Eliane Merlin Rocha M, Acco A, Cadena SMSC (2018) Effects of a new antiprotozoal drug, N,N'-diphenyl-4-methoxy-benzamidine, on energy-linked functions of rat liver mitochondria. Chem Biol Interact 279:34-42.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Liver
Corrochano 2018 Hum Mol Genet	2018	Corrochano S, Blanco G, Williams D, Wettstein J, Simon M, Kumar S, Moir L, Agnew T, Stewart M, Landman A, Kotiadis VN, Duchen MR, Wackerhage H, Rubinsztein DC, Brown SDM, Acevedo-Arozena A (2018) A genetic modifier suggests that endurance exercise exacerbates Huntington's disease. Hum Mol Genet 27:1723-31.	OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Dias 2018 Anal Biochem	2018	Dias C, Lourenco CF, Barbosa RM, Laranjinha J, Ledo A (2018) Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices. Anal Biochem 551:43-50.	LEAK ROUTINE ET	ROX	Intact cells	Mouse Rat	Nervous system
Dogan 2018 Cell Metab	2018	Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C (2018) Perturbed redox signaling exacerbates a mitochondrial myopathy. Cell Metab 28:764-77.	LEAK OXPHOS	N S CIV ROX	Isolated mitochondria	Mouse	Skeletal muscle
Hancock 2018 Elife	2018	Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M (2018) Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. Elife 7:e41044.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Heart
Sumbalova 2018 Recent Advances Mitochondr Med Coenzyme Q10	2018	Sumbalová Z, Garcia-Souza LF, Cizmarova B, Volani C, Gnaiger E (2018) Analysis of mitochondrial function in human blood cells. In: Recent advances in mitochondrial medicine and Coenzyme Q10. Gvozdjáková A, Cornelissen G, Singh RB eds, Nova Sciences:255-68.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Stanford 2018 Cell Metab	2018	Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ (2018) 12,13-diHOME: an exercise-induced lipokine that increases skeletal muscle fatty acid uptake. Cell Metab 27:1111-20.	LEAK OXPHOS ET	F ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Giacco 2018 FASEB J	2018	Giacco A, Delli Paoli G, Senese R, Cioffi F, Silvestri E, Moreno M, Ruoppolo M, Caterino M, Costanzo M, Lombardi A, Goglia F, Lanni A, de Lange P (2018) The saturation degree of fatty acids and their derived acylcarnitines determines the direct effect of metabolically active thyroid hormones on insulin sensitivity in skeletal muscle cells. FASEB J 33:1811-23.	LEAK ET ROUTINE	ROX	Intact cells	Rat	Skeletal muscle
Fernandes-Siqueira 2018 mSphere	2018	Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT (2018) Anaplerotic role of glucose in the oxidation of endogenous fatty acids during Dengue virus infection. mSphere 3.pii: e00458-17.	LEAK ET	F ROX	Intact cells	Human	Liver Other cell lines
Seite 2018 Sci Rep	2018	Seite S, Mourier A, Camougrand N, Salin B, Figueiredo-Silva AC, Fontagne-Dicharry S, Panserat S, Seiliez I (2018) Dietary methionine deficiency affects oxidative status, mitochondrial integrity and mitophagy in the liver of rainbow trout (Oncorhynchus mykiss). Sci Rep 8:10151.		N S CIV NS ROX	Homogenate	Fishes	Liver
Papadimitriou 2018 Thesis	2018	Papadimitriou ID (2018) The influence of ACTN3 R577X genotype on performance and muscle adaptations to a single bout of exercise . PhD Thesis 125.	OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Fuhrmann 2018 Cell Mol Life Sci	2018	Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, Brüne B (2018) Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia. Cell Mol Life Sci 75:3051-67.	LEAK ROUTINE OXPHOS ET	N S ROX	Isolated mitochondria Intact cells	Human
Qu 2018 FASEB J	2018	Qu C, Zhang S, Wang W, Li M, Wang Y, van der Heijde-Mulder M, Shokrollahi E, Hakim MS, Raat NJH, Peppelenbosch MP, Pan Q (2018) Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target. FASEB J 33:1008-19.	LEAK ROUTINE	CIV ROX	Intact cells	Human	Liver
Holland 2018 Cell Death Dis	2018	Holland OJ, Cuffe JSM, Dekker Nitert M, Callaway L, Kwan Cheung KA, Radenkovic F, Perkins AV (2018) Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery. Cell Death Dis 9:1150.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Genital
Garcia-Roche 2018 Redox Biol	2018	García-Roche M, Casal A, Carriquiry M, Radi R, Celia Quijano C, Cassina A (2018) Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies. Redox Biol 17:207-12.	LEAK OXPHOS ET	N NS ROX S	Permeabilized tissue	Rat Bovines	Liver
D'Souza 2018 J Lipid Res	2018	D'Souza K, Nzirorera C, Cowie AM, Varghese GP, Trivedi P, Eichmann TO, Biswas D, Touaibia M, Morris AJ, Aidinis V, Kane DA, Pulinilkunnil T, Kienesberger PC (2018) Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism. J Lipid Res 59:1805-17.	LEAK OXPHOS	F N S ROX	Permeabilized tissue	Mouse	Skeletal muscle
Fuhr 2018 EBioMedicine	2018	Fuhr L, El-Athman R, Scrima R, Cela O, Carbone A, Knoop H, Li Y, Hoffmann K, Laukkanen MO, Corcione F, Steuer R, Meyer TF, Mazzoccoli G, Capitanio N, Relógio A (2018) The circadian clock regulates metabolic phenotype rewiring via HKDC1 and modulates tumor progression and drug response in colorectal cancer. EBioMedicine 33:105-121.		ROX	Intact cells	Human	Other cell lines
Konopka 2018 Aging Cell	2018	Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF (2018) Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell 18:e12880.	OXPHOS ET LEAK	F N NS S ROX	Permeabilized tissue	Human	Skeletal muscle
Ost 2018 Curr Opin Clin Nutr Metab Care	2018	Ost M, Doerrier C, Gama-Perez P, Moreno-Gomez S (2018) Analysis of mitochondrial respiratory function in tissue biopsies and blood cells. Curr Opin Clin Nutr Metab Care 21:336-42.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Permeabilized tissue Isolated mitochondria Intact cells		Blood cells Platelet Skeletal muscle Liver Fat
Martinez-Palma 2018 Neurotherapeutics	2018	Martínez-Palma L, Miquel E, Lagos-Rodríguez V, Barbeito L, Cassina A, Cassina P (2018) Mitochondrial modulation by dichloroacetate reduces toxicity of aberrant glial cells and gliosis in the SOD1G93A rat model of amyotrophic lateral sclerosis. Neurotherapeutics 16:203-15.	LEAK ET	ROX	Intact cells	Rat	Nervous system
... further results

Abstracts: Residual oxygen consumption

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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Doerrier 2020 PaduaMuscleDays Poster	2020	Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Lelcu 2019 MiP2019	2019	Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Human	Platelet
Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT	2019	Cellular succinate transport and mitochondrial respiratory function in prostate cancer.	ROUTINE	S ROX	Intact cells	Human	Genital
Cardoso 2019 MiP2019	2019	Effects of glucose concentration in cell culture media on hepatocellular carcinoma HuH7 cells evaluated by high-resolution respirometry.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Dominguez-Amorocho 2019 MiP2019	2019	Role of Sirtuin 1/3 in CD4+ T cells activation and differentiation in obese and transplanted animals.	LEAK ET OXPHOS	ROX		Mouse	Lymphocyte
Van der Ende 2019 MiPschool Coimbra	2019	Mitochondrial respiration in muscle tissue of colon cancer patients.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Kramer 2019 Abstract IOC141	2019	Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.	LEAK OXPHOS ET	N CIV NS ROX		Human	Skeletal muscle
Goncalves Debora 2019 MiPschool Coimbra	2019	Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Drosophila
Sumbalova 2019a MiP2019	2019	Platelet mitochondrial function, coenzyme Q10, and oxidative stress in patients with chronic kidney diseases.	LEAK OXPHOS	F N S Gp CIV NS ROX	Intact cells	Human	Platelet
Betiu 2019 MiP2019	2019	Cell-permeable succinate improves amiodarone-induced mitochondrial Complex I and II inhibition in human platelets.	LEAK ET	ROX	Permeabilized cells Intact cells	Human	Platelet
Garcia-Roves 2019 MiPschool Coimbra	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Sumbalova 2019b MiP2019	2019	The decline of mitochondrial respiration in isolated platelets after short-term storage.	LEAK OXPHOS	F N S Gp CIV NS ROX	Intact cells	Human	Platelet
Chabi 2019 MiP2019	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Timohhina 2019 MiP2019	2019	Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.	LEAK OXPHOS ET	ROX		Human	Endothelial;epithelial;mesothelial cell
Doerrier 2019 MiP2019	2019	Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers.	LEAK ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT	2018	pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells	Human	HEK Kidney
Garcia-Roves 2018 MiP2018b	2018	Generating mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. Working Group 2 report. Garcia-Roves_Presentation	OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Doerrier 2018 ESCI2018	2018	High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease	LEAK ROUTINE OXPHOS ET	F N S Gp ROX CIV	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria	Human Mouse	Heart Skeletal muscle Nervous system Blood cells HEK
Krajcova 2018 ICO134	2018	Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Human	Skeletal muscle
Doerrier 2018 EBEC2018	2018	Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system Blood cells HEK Platelet
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4	2018	Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.	LEAK ROUTINE OXPHOS ET	S ROX	Intact cells	Human	Genital
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT	2018	Cellular succinate transport and mitochondrial respiratory function in prostate cancer.	ROUTINE LEAK OXPHOS ET	S ROX	Permeabilized cells Intact cells	Human	HEK Genital
Garipi 2018 MiPschool Tromso E2	2018	Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production	LEAK ROUTINE OXPHOS ET	CIV NS ROX	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Doerrier 2018 MiP2018a	2018	Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Schoepf 2018 33rd Annual EAU Congress Copenhagen	2018	Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.	LEAK OXPHOS ET	F N NS Other combinations ROX	Permeabilized cells Permeabilized tissue	Human	Genital
Krajcova 2018 MiPschool Tromso E2	2018	High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.	LEAK OXPHOS ET	N NS ROX	Homogenate	Human	Heart
Doerrier 2018 MiP2018c	2018	Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Hoel 2017 MiPschool Obergurgl	2017	A study on mitochondrial stress responses due to OXPHOS inhibition.	LEAK	ROX		Human	Nervous system
Nogueras 2017 MiPschool Obergurgl	2017	Mitochondrial dysfunction in peripheral blood mononuclear cells from multiple sclerosis patients.	LEAK ROUTINE ET	ROX	Intact cells		Blood cells
Michalak 2017 MiP2017	2017	The effect of anticoagulants on mitochondrial respiration in intact peripheral blood mononuclear cells.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Gnaiger 2017 MiPschool A4	2017	Respiratory pathway control in mitochondrial core energy metabolism: from bioenergetics to mitochondrial physiology.		F N S Gp CIV NS Other combinations ROX	Permeabilized cells Permeabilized tissue Isolated mitochondria
Gasparrini 2017 MiPschool Obergurgl	2017	Anti-inflammatory effects of strawberry and honey extracts in RAW 264.7 macrophages stressed with LPS.	LEAK	ROX		Mouse	Macrophage-derived
Garcia-Souza 2017 MiPschool Obergurgl	2017	Assessment of mitochondrial respiratory function in cryopreserved platelets.	ROUTINE ET	S CIV ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Rybacka-Mossakowska 2017 MiP2017	2017	Mitochondrial respiration in intact peripheral blood mononuclear cells in multiple sclerosis patients.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Sobotka 2017 Abstract MITOEAGLE Barcelona	2017	The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation	OXPHOS ET	F N S Gp ROX	Isolated mitochondria	Rat	Liver
Gnaiger 2017 MiPschool C1	2017	Apparent Complex IV excess capacity and biochemical thresholds.		N S CIV NS ROX	Permeabilized cells Permeabilized tissue Isolated mitochondria
Giampieri 2017 MiPschool Obergurgl	2017	Strawberry extract protects human dermal fibroblasts against oxidative stress and improves mitochondrial functionality.	LEAK	ROX			Fibroblast
Karavyraki 2017 MiPschool Obergurgl	2017	Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells.	LEAK	ROX	Intact cells	Human
Irving 2017 MiP2017	2017	Impact of acute exercise on PBMC respiratory function and methodological considerations.	LEAK ROUTINE OXPHOS ET	N NS ROX			Blood cells
Michalak 2017 Abstract MITOEAGLE Barcelona	2017	Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells	Human	Blood cells
Labieniec-Watala 2017 MiP2017	2017	Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation	OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Genital
Afrin 2017 MiPschool Obergurgl	2017	Induction of mitochondrial dysfunction by Manuka honey as a strategy for prevention of colon cancer in vitro model: a rising role on reactive oxygen species, apoptosis, and cell metabolism.	LEAK	ROX
Komlodi 2017 MiPschool Obergurgl	2017	Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production.	LEAK OXPHOS	N S Gp Other combinations ROX	Isolated mitochondria	Mouse	Nervous system
Chowdhury 2017 Blood	2017	Importance of mitochondrial metabolism as a selective therapeutic approach in chronic lymphocytic leukemia patients.	LEAK	ROX	Intact cells	Human	Lymphocyte
Collins 2017 MiPschool Obergurgl	2017	The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.	OXPHOS	F N S Gp CIV NS ROX	Intact cells
Garcia-Roves 2017 MiP2017	2017	Mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. MitoEAGLE WG2 pilot study. Garcia-Roves_Presentation	OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Bento 2017 MITOEAGLE Obergurgl	2017	Isolation of human urine-derived stem cells for mitochondrial function profile assessment.	LEAK ET	ROX	Intact cells	Human	Stem cells
Reboredo-Rodriguez 2017 MiPschool Obergurgl	2017	Protective effect of a polyphenol-rich strawberry extract on oxidative and endoplasmic reticulum stresses in HepG2 cell line.	LEAK ET	ROX		Human	Liver
Markova 2017 MiPschool Obergurgl	2017	Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Heart
Markova 2017 MiP2017	2017	Porcine sepsis and associated myocardial depression.	LEAK OXPHOS	N S CIV NS ROX		Pig	Heart
Gnaiger 2017 MiPschool A1	2017	Elemental steps towards understanding mitochondrial core energy metabolism: coupling control.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells Permeabilized cells Permeabilized tissue Isolated mitochondria
Laner 2016 Abstract MitoFit Science Camp 2016	2016	OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Krumschnabel 2016b Abstract MitoFit Science Camp 2016	2016	O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.	LEAK OXPHOS ET	N S NS ROX		Human	Kidney HEK
Sumbalova 2016b Abstract MitoFit Science Camp 2016	2016	Human blood cells: isolation and HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Bezuidenhout 2016b Abstract MitoFit Science Camp 2016	2016	Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Mouse	Skeletal muscle
Sobotka 2016 Abstract IOC116	2016	Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11	LEAK OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Isolated mitochondria	Rat	Liver
Lamberti 2016 Abstract MitoFit Science Camp 2016	2016	Development of a reference sample for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX		Human	Kidney HEK
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.	LEAK OXPHOS ET	F N S NS ROX		Mouse	Nervous system
Krumschnabel 2016a Abstract MitoFit Science Camp 2016	2016	O2k-Protocols: Mitochondrial preparations for HRR.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate Isolated mitochondria	Mouse	Heart
Laner 2016 Abstract Mito Xmas Meeting Innsbruck	2016	OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Doerrier 2016 Abstract MitoFit Science Camp 2016	2016	Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria	Human Mouse	Heart Blood cells HEK Platelet
Hoppel 2016c Abstract MitoFit Science Camp 2016	2016	Mitochondrial respiration in permeabilized skin fibroblasts.	OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck	2016	Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Mouse	Heart
Blecha 2015 Abstract MiP2015	2015	Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.	LEAK ET	ROX
Calzia 2015 Abstract MiP2015	2015	Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.	LEAK OXPHOS ET	N S ROX		Human	Skeletal muscle
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Karabatsiakis 2015 Abstract MiP2015	2015	Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.	LEAK ROUTINE OXPHOS ET	ROX		Human	Blood cells
Van Dyk 2015 Abstract MiPschool Cape Town 2015	2015	Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer.	LEAK ROUTINE ET	N ROX	Isolated mitochondria	Human	Other cell lines Fibroblast
Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Rat	Heart
Rohlena 2015 Abstract MiP2015	2015	Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.	ROUTINE OXPHOS ET	S ROX	Permeabilized cells Isolated mitochondria	Human	Other cell lines
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II	2015	On coupling control of mitochondrial respiration. What is wrong with the RCR?	LEAK ROUTINE OXPHOS ET	N S ROX
Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F N S NS ROX	Permeabilized cells Permeabilized tissue		Blood cells Lymphocyte Platelet
Laner 2015 Abstract MiP2015	2015	Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Dyrstad 2015 Abstract MiPschool London 2015	2015	Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells.	LEAK ROUTINE ET	N ROX		Human	Endothelial;epithelial;mesothelial cell Other cell lines
Galina 2015 Abstract MiP2015	2015	High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles.	LEAK	N S ROX	Permeabilized tissue	Rat	Skeletal muscle
Doerrier 2014 Abstract SECF	2014	Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Heart
Felser 2014 Abstract MiP2014	2014	Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry.	ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell HeLa Fibroblast
Amoedo 2013 Abstract MiP2013	2013	Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Enzyme Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Other cell lines
Krumschnabel 2013 Abstract MiP2013	2013	Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse Fishes	Heart Nervous system Liver
Rodrigues 2013 Abstract MiP2013	2013	Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.	LEAK ROUTINE ET	ROX	Intact cells		Genital
Jezek 2013 Abstract MiP2013	2013	Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S ROX	Isolated mitochondria Intact cells	Mouse	Lung;gill Islet cell;pancreas;thymus
Pecina 2013 Abstract MiP2013	2013	Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S Gp NS Other combinations ROX	Permeabilized cells Homogenate	Human	Blood cells Lymphocyte
Slinde 2013 Abstract MiP2013	2013	Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N ROX	Permeabilized tissue Isolated mitochondria	Other mammals Fishes	Heart Liver Blood cells
Christen 2013 Abstract MiP2013	2013	Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08.	OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Other mammals Fishes	Heart
Szibor 2013 Abstract MiP2013	2013	Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	ROX	Isolated mitochondria Oxidase;biochemical oxidation	Mouse	Heart Skeletal muscle Nervous system Liver Lung;gill
Larsen FJ 2013 Abstract MiP2013	2013	Larsen FJ, Schiffer TA, Lundberg JO, Weitzberg E (2013) Human mitochondria has a unique response to ischemia-reperfusion injury compared to mitochondria from rat, mouse and pig . Mitochondr Physiol Network 18.08.	OXPHOS	ROX	Isolated mitochondria	Human Pig Mouse Rat
Votion 2013 Abstract MiP2013	2013	Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08.	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Oliveira MF 2013 Abstract MiP2013	2013	Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV ROX	Intact organism Intact organ Permeabilized cells Permeabilized tissue Homogenate Intact cells	Human Drosophila Hexapods Other invertebrates	Skeletal muscle Neuroblastoma
Cavalcanti de Albuquerque 2013 Abstract MiP2013	2013	Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N S Gp NS ROX	Intact organism Permeabilized tissue	Rat	Skeletal muscle
Pichaud 2013 Abstract MiP2013	2013	Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Drosophila Hexapods	Skeletal muscle
Watala 2012 Abstract Bioblast	2012	Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12.	ROUTINE ET	NS ROX	Isolated mitochondria Enzyme Intact cells	Human Rat	Endothelial;epithelial;mesothelial cell Blood cells Platelet
Pesta 2011Abstract Mitochondrial Medicine-Training	2011	Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle