Rasmussen 2003 Eur J Physiol

Rasmussen UF, Krustrup P, Kjaer M, Rasmussen HN (2003) Human skeletal muscle mitochondrial metabolism in youth and senescence: no signs of functional changes in ATP formation and mitochondrial oxidative capacity. Pflugers Arch. – Eur. J. Physiol. 446: 270-278.

Rasmussen UF, Krustrup P, Kjaer M, Rasmussen HN (2003) Eur. J. Physiol.

Abstract:

Labels:

Organism: Human  Tissue;cell: Skeletal Muscle"Skeletal Muscle" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property.  Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.  Enzyme: Complex I, Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property., Complex V; ATP Synthase"Complex V; ATP Synthase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.  Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Flux Control; Additivity; Threshold; Excess Capacity"Flux Control; Additivity; Threshold; Excess Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property. 

References

Both muscle strength and peak contraction velocity decline, in some muscles even from the age of 20

[8, 15, 16 17, 22, 23, 26, 27, 28, 29, 30, 32, 36, 37]

The response to training is independent of age

[8, 9, 15, 17, 22, 23, 30, 32, 36, 37].

Loss of type-II fibres is greater than that of type-I

[15, 16, 22, 23, 26, 27, 28, 37].

==Cytochrome oxidase deficient fibres appear later in increasing, but very small numbers

[8, 9, 10, 33, 35, 44, 52].

8. Brierley EJ, Johnson MA, James OFW, Turnbull DM (1996) Effects of physical activity and age on mitochondrial function. Q. J. Med. 89: 251–258.

9. Brierley EJ, Johnson MA, Bowman A, Ford GA, Subhan F, Reed JW, James OFW, Turnbull DM (1997) Mitochondrial function in muscle from elderly athletes. Ann. Neurol. 41: 114–116.

10. Brierley EJ, Johnson MA, Lightowlers RN, James OFW, Turnbull DM (1998) Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann. Neurol. 43: 217–223.

15. Coggan AR, Spina RJ, Rogers MA, King DS, Brown M, Nemeth PM, Holloszy JO (1990) Histochemical and enzymatic characteristics of skeletal muscle in master athletes. J. Appl. Physiol. 68: 1896–1901.

16. Coggan AR, Spina RJ, King DS, Rogers MA, Brown M, Nemeth PM, Holloszy JO (1992) Histochemical and enzymatic comparison of the gastrocnemius muscle of young and elderly men and women. J. Gerontol. 47: B71–B76.

17. Coggan AR, Abduljalil AM, Swanson SC, Earle MS, Farris JW, Mendenhall LA, Robitaille P-M (1993) Muscle metabolism during exercise in young and older untrained and endurance-trained men. J. Appl. Physiol. 75: 2125–2133.

22. Kent-Braun JA, NG AV (2000) Skeletal muscle oxidative capacity in young and older women and men. J. Appl. Physiol. 89: 1072–1078.

23. Klitgaard H, Mantoni M, Schiaffino S, Ausoni S, Gorza L, Laurent-Winter C, Schnohr P, Saltin B (1990) Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds. Acta Physiol. Scand. 140: 41–54.

26. Larsson L, Grimby G, Karlsson J (1979) Muscle strength and speed of movement in relation to age and muscle morphology. J. Appl. Physiol. 46: 451–456.

27. Lexell J (1995) Human aging, muscle mass, and fiber type composition. J. Gerontol. 50: A11–A16.

28. Lexell J, Taylor CC, Sjöström M (1988) What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J. Neurol. Sci. 84: 275–294.

29. McCully KK, Fielding RA, Evans WJ, Leigh JS, Posner JD (1993) Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles. J. Appl. Physiol. 75: 813–819.

30. Meredith CN, Frontera WR, Fisher EC, Hughes VA, Herland JC, Edwards J, Ewans WJ (1989) Peripheral effects of endurance training in young and old subjects. J. Appl. Physiol. 66: 2844–2849.

32. Örlander J, Aniansson A (1980) Effects of physical training on skeletal muscle metabolism and ultrastructure in 70 to 75-year-old men. Acta Physiol. Scand. 109: 149–154.

33. Ozawa T (1997) Genetic and functional changes in mitochondria associated with aging. Physiol. Rev. 77: 425–464.

35. Pesce V, Cormio A, Fracasso F, Vecchiet J, Felzani G, Lezza AMS, Cantatore P, Gadaleta MN (2001) Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle. Free Radic. Biol. Med. 30: 1223–1233.

36. Proctor DN, Joyner MJ (1997) Skeletal muscle mass and the reduction of VO2,max in trained older subjects. J. Appl. Physiol. 82: 1411–1415.

37. Proctor DN, Sinning WE, Walro JM, Sieck GC, Lemon PWR (1995) Oxidative capacity of human muscle fiber types: effects of age and training status. J. Appl. Physiol. 78: 2033–2038.

44. Rifai Z, Welle S, Kamp C, Thornton CA (1995) Ragged red fibers in normal aging and inflammatory myopathy. Ann. Neurol. 37: 24–29.

52. Wilson PD, Franks LM (1975) The effect of age on mitochondrial ultrastructure and enzymes. Adv. Exp. Med. Biol. 53: 171–183.