Raffa 2010 Bull Hist Chem
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| Raffa RB, Tallarida RJ (2010) ‘Affinity’: historical development in chemistry and pharmacology. Bull Hist Chem 35:7-16. |
Raffa RB, Tallarida RJ (2010) Bull Hist Chem
Abstract: Colloquial use of the term affinity evolved historically from meaning ‘proximity‘ to meaning ‘attraction.’ Scientific use of affinity underwent a similar evolution and as traced in this review further evolved in chemistry and thermodynamics to quantify the driving force of chemical reactions. Pharmacology developed a related, but different definition for affinity. The different fields could continue to define and use affinity in different ways, but confusion might arise as thermodynamics is increasingly used in practical applications in drug-discovery (5, 45). Recognition of the differences and some type of unification would seem worthwhile.
• Bioblast editor: Gnaiger E
Attraction, affinity, force
* Affinity * Force
