Difference between revisions of "ROUTINE respiration"
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==Why not 'basal respiration', and what about 'State 3.5'?== | ==Why not 'basal respiration', and what about 'State 3.5'?== | ||
'''Basal respiration''' | '''Basal respiration''' or "basel metabolic rate" bis frequently used in the context of isolated mitochondria as [[LEAK respiration]] (State 4). Importantly, we have to make a clear distinction between (oligomycin-inhibited) LEAK respiration and physiologically controlled [[ROUTINE respiration]], none of which conform to the physiological definition of [[basal respiration]]. |
Revision as of 18:50, 11 October 2011
Description
In the intact cell, ROUTINE respiration in the physiological coupling state R, is controlled by cellular energy demand, energy turnover and the degree of coupling to phosphorylation (intrinsic uncoupling and pathological dyscoupling). R and growth of cells is supported by exogenous substrates in culture media. In media without energy substrates, R depends on endogenous substrates. R cannot be measured in permeabilized cells or isolated mitochondria.
Abbreviation: R
Reference: MiPNet12.15, MiPNet08.09, Gnaiger_2008_POS
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Why not 'basal respiration', and what about 'State 3.5'?
Basal respiration or "basel metabolic rate" bis frequently used in the context of isolated mitochondria as LEAK respiration (State 4). Importantly, we have to make a clear distinction between (oligomycin-inhibited) LEAK respiration and physiologically controlled ROUTINE respiration, none of which conform to the physiological definition of basal respiration.