Difference between revisions of "PMS-pathway control state"
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[[Pyruvate]] (P) is oxidatively decarboxylated to acetyl-CoA and CO<sub>2</sub>, yielding [[NADH]] catalyzed by pyruvate dehydrogenase. [[Malate]] (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009). | [[Pyruvate]] (P) is oxidatively decarboxylated to acetyl-CoA and CO<sub>2</sub>, yielding [[NADH]] catalyzed by pyruvate dehydrogenase. [[Malate]] (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009). | ||
|info=[[Gnaiger | |info=[[Gnaiger 2020 BEC MitoPathways]] | ||
[[File:PMS.jpg|right|400px|PMS]] | [[File:PMS.jpg|right|400px|PMS]] | ||
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::: ''More details'' | ::: ''More details'' | ||
::::» [[Additive effect of convergent electron flow]] | ::::» [[Additive effect of convergent electron flow]] | ||
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:::*[[SUIT-004]] | :::*[[SUIT-004]] | ||
::::* DL-Protocol for permeabilized fibers (pfi): [[SUIT-004 O2 pfi D010]] | ::::* DL-Protocol for permeabilized fibers (pfi): [[SUIT-004 O2 pfi D010]] | ||
{{MitoPedia concepts | |||
|mitopedia concept=SUIT state | |||
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Revision as of 19:56, 1 January 2021
- high-resolution terminology - matching measurements at high-resolution
PMS-pathway control state
Description
PMS: Pyruvate & Malate & Succinate.
MitoPathway control: CI&II
Pyruvate (P) is oxidatively decarboxylated to acetyl-CoA and CO2, yielding NADH catalyzed by pyruvate dehydrogenase. Malate (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009).
Abbreviation: PMS
Reference: Gnaiger 2020 BEC MitoPathways
PMSL
PMS pathway in the LEAK state can be evaluated in the following SUIT protocols:
PMSP
PMS pathway in the OXPHOS state can be evaluated in the following SUIT protocols:
PMSE
PMS pathway in the ET state can be evaluated in the following SUIT protocols:
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- DL-Protocol for permeabilized fibers (pfi): SUIT-004 O2 pfi D010
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MitoPedia concepts:
SUIT state
