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Oroboros Ecosystem Agenda - 2020 week 13
2024 Week 13
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2024 Week 14
- Apr-01 Mo April - Parkinson's Disease Awareness Month
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"Although the chain of events leading to this respiration deficit is currently not understood, the findings constitute a robust assay for the progressive pathology induced by PINK1 deficiency."
- Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken HH, Becker D, Voos W, Leuner K, Müller WE, Kudin AP, Kunz WS, Zimmermann A, Roeper J, Wenzel D, Jendrach M, García-Arencíbia M, Fernández-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rüb U, Chen A, Nussbaum RL, Auburger G (2009) Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. »Bioblast link«
- from the O2k-Network »US CA San Francisco Nussbaum RL« and »DE Frankfurt Eckert GP«
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"Why is it important to check the H2O2 sensitivity when conducting an Amplex UltraRed (AmR) assay?
The sensitivity is influenced by experimental time, medium composition, added chemicals and sample, requiring multiple H2O2 calibrations throughout the measurement. After the initial AmR calibration, ensure that the sensitivity is within the recommended range.
- »MiPNet24.10 H2O2 flux analysis«, »Amplex UltraRed«
- communicated by »Grings Mateus« and »Schmitt Sabine«
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Oroboros of the month
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- In the artwork "First Fruits of the Earth Offered to Saturn" at the Palazzo Vecchio, Saturn (Cronus in Greek mythology) is holding the Ouroboros in the hand, symbolizing the eternal cycle of renewal and the interconnectedness of beginning and end.
- » Oroboros pictures of the month
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In focus
- 0.5-mL and 2-mL O2k-chambers - flexibility in high-resolution respirometry
- featured MitoPedia page: »Cell count and normalization in HRR«
Last update March 29, 2024
Bioblast alert 2020(13)
Some terms in “Mitochondrial physiology” Bioenergetics Communications 2020.1 (States and rates) did not look familiar ― what is the elementary unit [x]?
Fundamental answers, a critical discussion on the SI unit for count, and the meaning of Euclid’s unit and Euclid’s number are presented in an unusual ‘canonical review’:
- Gnaiger Erich (2020) Canonical reviewer's comments on: Bureau International des Poids et Mesures (2019) The International System of Units (SI) 9th ed. MitoFit Preprint Arch 2020.4 doi:10.26124/mitofit:200004. - »Bioblast link«
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Stay alert
Funding acknowledgments
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