Nuclear receptors: Difference between revisions

Latest revision as of 16:40, 28 May 2012

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Nuclear receptors

Description

Nuclear receptors are ligand-dependent transcription factors.

Abbreviation: NRs

Reference: Burris_2012_Chem Biol;

In contrast to extracellular receptors such as the insulin receptor, intracellular receptors directely bind endocrine hormones and dietary lipids. Nuclear receptors interact directly with lipophilic ligands and bind to specific DNA response elements to regulate expression of target genes. They include receptors for steroid hormones, thyroid hormone, various lipids and oxysterols. Nuclear receptors are promising drug targets for diseases such as inflammation, cancer, and metabolic disorders. All nuclear receptor members have a similar canonical domain structure that includes an N-terminal activation domain and conserved DNA and ligand-binding domains. Well known members of the nuclear-receptor superfamily include the three different ligand-activated peroxisome proliverator activated receptor (PPAR) subtypes, PPAR-α, PPAR-β/δ, and PPAR-γ or the retinoid X receptor (RXR).

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 {{MitoPedia
-|abbr=NR
+|abbr=NRs
 |description=Nuclear receptors are ligand-dependent transcription factors.
+|info=[http://www.ncbi.nlm.nih.gov/pubmed/22284354 Burris_2012_Chem Biol];
 }}
-{{MitoPedia methods}}
+In contrast to extracellular receptors such as the insulin receptor, intracellular receptors directely bind endocrine hormones and dietary lipids. Nuclear receptors interact directly with lipophilic ligands and bind to specific DNA response elements to regulate expression of target genes. They include receptors for steroid hormones, thyroid hormone, various lipids and oxysterols. Nuclear receptors are promising drug targets for diseases such as inflammation, cancer, and metabolic disorders. All nuclear receptor members have a similar canonical domain structure that includes an N-terminal activation domain and conserved DNA and ligand-binding domains.
-{{MitoPedia topics}}
+Well known members of the nuclear-receptor superfamily include the three different ligand-activated peroxisome proliverator activated receptor (PPAR) subtypes, [[PPAR-α]], [[PPAR-β/δ]], and [[PPAR-γ]] or the retinoid X receptor (RXR).
-In contrast to extracellular receptors such as the insulin receptor, these intracellular receptors can bind endocrine hormones and dietary lipids. Nuclear receptors interact directly with lipophilic ligands and bind to specific DNA response elements to regulate expression of target genes. All nuclear receptor members have a similar canonical domain structure that includes an N-terminal activation domain and conserved DNA and ligand-binding domains.
-Well known members of the nuclear-receptor superfamily include the three different ligand-activated peroxisome proliverator activated receptor (PPAR) subtypes, PPAR-α, PPAR-β/δ, and PPAR-γ or the retinoid X receptor (RXR).