Mu 2022 Biochim Biophys Acta Mol Basis Dis

Mu C, Tompkins TA, Rho JM, Scantlebury MH, Shearer J (2022) Gut-based manipulations spur hippocampal mitochondrial bioenergetics in a model of pediatric epilepsy. https://doi.org/10.1016/j.bbadis.2022.166446

» Biochim Biophys Acta Mol Basis Dis 1868:166446. PMID: 35589071

Mu Chunlong,  Tompkins Thomas A, Rho Jong M, Scantlebury Morris H,  Shearer Jane (2022) Biochim Biophys Acta Mol Basis Dis

Abstract: A growing body of evidence supports a role of the gut microbiota in regulating diverse physiological processes, including neural function and metabolism via the gut-brain axis. Infantile spasms syndrome is an early-onset epileptic encephalopathy associated with perturbed brain mitochondrial bioenergetics. Employing a neonatal rat model of infantile spasms, mitochondria respirometry and biochemical analyses, the present study reveals that gut microbiota manipulation by diet, antibiotics and probiotics have the potential to enhance hippocampal mitochondrial bioenergetics. Although preliminary in nature, our data reveal that microbial manipulation that regulates brain mitochondrial function may be a novel strategy for the treatment of epileptic disorders. • Keywords: Epilepsy, Gut microbiota, Ketogenic diet, Mitochondria bioenergetics, Probiotics • Bioblast editor: Plangger M • O2k-Network Lab: CA Calgary Shearer J

Labels: MiParea: Respiration  Pathology: Other 

Organism: Rat 

HRR: Oxygraph-2k 

2022-11, Labelling