Difference between revisions of "MiPNet12.15 RespiratoryStates"
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|authors=Gnaiger E | |authors=Gnaiger E | ||
|year=* | |year=* | ||
|journal=Mitochondr. Physiol. Network | |||
|mipnetlab=AT_Innsbruck_Oroboros | |mipnetlab=AT_Innsbruck_Oroboros | ||
|info=[http://www.oroboros.at/index.php? | |abstract=In [[oxidative phosphorylation]], the endergonic process of phosphorylation of ADP to ATP is coupled to the exergonic process of electron transfer to oxygen. [[Coupling]] is achieved through the proton pumps generating and utilizing the protonmotive force in a proton circuit across the inner mitochondrial membrane. This proton circuit is partially uncoupled by [[proton leak]]s. Three different meanings of uncoupling (or coupling) are distinguished by defining intrinsically [[uncoupled]], pathologically [[dyscoupled]], and experimentally [[non-coupled]] respiration. | ||
Respiratory steady states have been clearly defined by Chance and Williams (1955) according to a protocol for oxygraphic experiments with isolated mitochondria. The present state of terminology, however (e.g. [[State 2]], requires clarification, particularly for extending bioenergetics to mitochondrial respiratory physiology of the living cell. | |||
|info=[http://www.oroboros.at/index.php?respiratorystates MiPNet12.15] | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|discipline=Mitochondrial Physiology | |||
|topics=Respiration; OXPHOS; ETS Capacity, Coupling; Membrane Potential, Substrate; Glucose; TCA Cycle, Redox State | |||
|instruments=Theory | |instruments=Theory | ||
|articletype=Protocol; Manual, MiPNet-online Publication | |articletype=Protocol; Manual, MiPNet-online Publication | ||
}} | }} | ||
Revision as of 10:39, 21 October 2010
| Gnaiger E. MitoPathways: Respiratory states and flux control ratios. Mitochondr. Physiol. Network 12.15. |
) Mitochondr. Physiol. Network
Abstract: In oxidative phosphorylation, the endergonic process of phosphorylation of ADP to ATP is coupled to the exergonic process of electron transfer to oxygen. Coupling is achieved through the proton pumps generating and utilizing the protonmotive force in a proton circuit across the inner mitochondrial membrane. This proton circuit is partially uncoupled by proton leaks. Three different meanings of uncoupling (or coupling) are distinguished by defining intrinsically uncoupled, pathologically dyscoupled, and experimentally non-coupled respiration.
Respiratory steady states have been clearly defined by Chance and Williams (1955) according to a protocol for oxygraphic experiments with isolated mitochondria. The present state of terminology, however (e.g. State 2, requires clarification, particularly for extending bioenergetics to mitochondrial respiratory physiology of the living cell.
• O2k-Network Lab: AT_Innsbruck_Oroboros
Labels:
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Redox State"Redox State" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
HRR: Theory
