MiP2014 Abstracts in the MiPMap

MiP2014 Session A

	Has title	Event	Mammal and model	Tissue and cell	Stress	Diseases
Alberici 2014 Abstract MiP2014	Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism.	C3 Poster	Rat	Skeletal muscle	Oxidative stress;RONS	Diabetes Obesity
Ali 2014 Abstract MiP2014	Oxygen-consuming and ROS-producing activities in synaptosomes.	B4 Oral		Nervous system	Oxidative stress;RONS
Amoedo 2014 Abstract MiP2014	The metabolic panorama during tumor progression towards malignancy.	B3 Oral		Other cell lines		Cancer
Balazova 2014 Abstract MiP2014	Balanced ratio of anionic mitochondrial phospholipids is important for mitochondrial functions in the yeast Saccharomyces cerevisiae.	A1 Poster	Saccharomyces cerevisiae		Temperature
Borutaite 2014 Abstract MiP2014	Controversies regarding cytochrome c test for mitochondrial membrane integrity.	C2 Oral	Rat	Heart Nervous system	Ischemia-reperfusion Permeability transition
Bresciani Martins de Andrade 2014 Abstract MiP2014	Mitochondrial function in white adipose tissue: palmitoleic acid (C16:1n7) treatment enhances white adipocyte oxygen consumption.	A4 Oral		Fat		Diabetes Obesity
Bristot 2014 Abstract MiP2014	High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations.	C1 Oral	Human	Fibroblast	Oxidative stress;RONS	Cancer
Brown DA 2014 Abstract MiP2014	The cardiolipin-targeting peptide Bendavia preserves post-ischemic mitochondrial energetics by sustaining respiratory supercomplexes.	C3 Oral	Rat	Heart	Ischemia-reperfusion
Brown G 2014 Abstract MiP2014	Complex I inhibition in microglia and inflammatory neuronal loss.	C1 Oral		Nervous system	Oxidative stress;RONS	Aging;senescence Parkinson's
Burtscher 2014 Abstract MiP2014	Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain.	A4 Oral	Mouse	Nervous system
Busch 2014 Abstract MiP2014	Mitochondrial fusion and fission dynamics are indispensable for homogenization of inner mitochondrial membrane proteins: insights from superresolution studies.		Human
Cherubini 2014 Abstract MiP2014	Striatal deregulation of Cdk5 alters mitochondrial dynamics in Huntington’s disease.	A2 P-flash		Nervous system	Mitochondrial disease	Neurodegenerative
Coen 2014 Abstract MiP2014	Exercise improves insulin sensitivity and muscle mitochondrial respiration following Roux-en-Y gastric bypass surgery.	A3 Oral	Human	Skeletal muscle		Diabetes
Contreras-Ferrat 2014 Abstract MiP2014	Insulin increases mitochondrial calcium levels regulating both mitochondrial function and intracellular signaling in muscle; this effect is disrupted in fibers from short-term high fat diet fed mice. Mitochondr Physiol Network 19.13.	C3 Oral	Mouse	Skeletal muscle		Diabetes
Dohlmann 2014 Abstract MiP2014	Mitochondrial adaptations to high-intensity training in young and elderly men and women.	A3 Oral	Human	Skeletal muscle HeLa Fibroblast		Aging;senescence
Eggimann 2014 Abstract MiP2014	Adaptation to nutrient availability in human fibroblasts with mitochondrial dysfunction: the role of sirtuins.	C1 Oral	Human	Fibroblast	Mitochondrial disease
Eide 2014 Abstract MiP2014	Reversible mitochondrial DNA mutagenesis.	A1 Oral	Human	Nervous system Stem cells		Aging;senescence
El-Bacha 2014 Abstract MiP2014	Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.	C3 Oral	Human	Liver	Cell death	Cancer
Felser 2014 Abstract MiP2014	Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry.	B4 Oral	Human	Endothelial;epithelial;mesothelial cell HeLa Fibroblast
Ferreira 2014 Abstract MiP2014	Impairment of bioenergetic parameters induced by acute carnosine administration in skeletal muscle of young rats.	C3 Poster	Rat	Skeletal muscle		Inherited
Figueira 2014 Abstract MiP2014	Mitochondrial respiration and calcium transport in rat tissues: conversely from skeletal muscle, heart and brain, isolated liver mitochondria exhibit gender dimorphism in respiratory activity.	C2 Oral	Rat	Heart Skeletal muscle Nervous system Liver	Permeability transition
Galina 2014 Abstract MiP2014	Effects of perinatal asphyxia in mitochondria of brain during development of the central nervous system.	B3 Oral	Rat	Nervous system	Ischemia-reperfusion Permeability transition
Gnaiger 2014 Abstract MiP2014	Cell ergometry: OXPHOS and ET-pathway coupling efficiency.	A4 Oral
Gnaiger 2014 Preface MiP2014	MiPArt - Mitchell's equation.
Grefte 2014 Abstract MiP2014	Myotube formation does not require mitochondrial ATP production but is inhibited by rotenone via the Rho-associated, coiled-coil containing protein kinase II.	B3 P-flash	Mouse	Skeletal muscle	Oxidative stress;RONS
Hahn 2014 Abstract MiP2014	Validation of oxygen consumption measurements in muscle and fibroblasts from patients with mitochondrial diseases.	C1 Poster	Human	Skeletal muscle Fibroblast	Mitochondrial disease
Harrison 2014 Abstract MiP2014	The relationship between cytochrome redox state and oxygen consumption in isolated mouse and beef heart mitochondria during hypoxia.	B4 Oral	Rat Bovines	Heart
Hepple 2014 Abstract MiP2014	Denervation modulates mitochondrial function when aging muscle atrophy becomes severe: implications for therapeutic intervention.	A3 Oral	Human	Skeletal muscle	Cell death Permeability transition Oxidative stress;RONS Mitochondrial disease	Aging;senescence
Herbst 2014 Abstract MiP2014	Analysis of mitochondrial function in multiple brain regions through in situ permeabilization.	A4 Oral	Mouse	Nervous system
Herminghaus 2014 Abstract MiP2014	Severity of polymicrobial sepsis modulates mitochondrial function in rat liver.	A4 Poster	Rat	Liver		Sepsis
Hickey 2014 Abstract MiP2014	Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart.	B4 Oral	Rat	Heart	Ischemia-reperfusion Oxidative stress;RONS	Cardiovascular Diabetes Myopathy
Holloway 2014 Abstract MiP2014	Acute diet-induced insulin resistance is associated with increased adipose tissue mitochondrial ROS emissions.	B2 Oral	Mouse	Fat	Oxidative stress;RONS	Diabetes Obesity
Holmstroem 2014 Abstract MiP2014	Homozygous missense mutation in the human NARS2 gene results in reduced homodimerization of mitochondrial AsnRS enzyme in a patient with Alpers syndrome.	A1 Oral	Human	Fibroblast		Neurodegenerative
Horscroft 2014 Abstract MiP2014	Substrate utilisation in the hypoxic heart: a glycolysis/glucose oxidation mismatch?	B3 Oral	Rat	Heart	Ischemia-reperfusion
Houghton 2014 Abstract MiP2014	The effect of bioactive phenolics on chronic mitochondrial stress associated with the onset of diabetes.	B2 Oral	Human	Liver	Oxidative stress;RONS	Diabetes
Houstek 2014 Abstract MiP2014	Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation.	A1 Poster
Iyer 2014 Abstract MiP2014	Bioenergetics: arts meets gentle science in sickness and in health.	C4 Oral	Human			Obesity
Jaburek 2014 Abstract MiP2014	The role of phospholipase A2γ in the regulation of mitochondrial uncoupling protein 2–dependent antioxidant function.	B2 Oral		Islet cell;pancreas;thymus	Oxidative stress;RONS	Diabetes
Jana Prado 2014 Abstract MiP2014	Defining the role of mitochondrial electron transfer Complex I on the modulation of Ca2+ homeostasis: effects of metformin on cancer cell metabolism. Mitochondr Physiol Network 19.13.	C3 P-flash				Cancer Diabetes
Jezek 2014 Abstract MiP2014	Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.	A2 Oral		Other cell lines	Ischemia-reperfusion
Kabir 2014 Abstract MiP2014	Declining follicular reserve triggers mitochondrial pathway of granulosa cell apoptosis and accelerates the rate of follicular decay.	C3 Oral	Rat	Genital	Cell death
Kandashvili 2014 Abstract MiP2014	Regulation of energy metabolism in human colorectal cancer cells in situ.	B3 Poster	Human	Endothelial;epithelial;mesothelial cell		Cancer
Kane 2014 Abstract MiP2014	Assessing mitochondrial lactate oxidation in permeabilized skeletal muscle fibers highlights important experimental considerations: malate concentration and the cytochrome c effect.	C2 Oral	Rat	Skeletal muscle
Kluckova 2014 Abstract MiP2014	Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.	C4 Oral		Other cell lines	Cell death Oxidative stress;RONS	Cancer
Komlodi 2014 Abstract MiP2014	Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation.	B1 Poster	Guinea pig	Nervous system	Ischemia-reperfusion	Alzheimer's Parkinson's
Koopman 2014 Abstract MiP2014	Redox regulation of mitochondrial dynamics and function.	A2 Oral			Oxidative stress;RONS
Kowaltowski 2014 Abstract MiP2014	Luévano-Martínez LA, Forni FM, dos Santos VT, Souza-Pinto NC, Kowaltowski AJ (2014) Cardiolipin is a key determinant for mitochondrial DNA stability and segregation.	A1 Oral	Saccharomyces cerevisiae		Temperature
Krumschnabel 2014 Abstract MiP2014	Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.	B4 Poster	Mouse	Nervous system	Oxidative stress;RONS
Kruszewski 2014 Abstract MiP2014	Complementation of nuclear-encoded proteins which maintain mitochondrial DNA in S. cerevisiae with homologous proteins from other fungi species.	A1 P-flash	Saccharomyces cerevisiae Fungi
Lai 2014 Abstract1 MiP2014	Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.	C2 Oral	Rat Dog	Heart Skeletal muscle Fibroblast
Lai 2014 Abstract2 MiP2014	Bioenergetic differences between permeabilized red and white fibers of a non-obese model of type II diabetes.	C2 Poster	Rat	Skeletal muscle		Diabetes Obesity
Laner 2014 Abstract MiP2014	Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers.	C2 Poster	Dog	Skeletal muscle
Larsen 2014 Abstract MiP2014	The effect of high intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue.	A3 Oral	Human	Skeletal muscle Fat		Obesity
MacDonald 2014 Abstract MiP2014	The mitochondrial enzyme 4-hydroxy-2-oxoglutarate aldolase (HOGA) – involvement in the TCA cycle.	B1 Oral	Rat	Heart Nervous system Liver Kidney
Maddalena 2014 Abstract MiP2014	Experimental considerations for evaluating bioenergetic effects of a mitochondria-targeted compound, TPP-IOA.	C3 Poster			Cell death
Mahdaviani 2014 Abstract MiP2014	Hormone‐induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.	A2 Oral	Mouse	Fat Other cell lines
Meszaros 2014 Abstract MiP2014	Methodological aspects of assessing mitochondrial function in small intestinal mucosal samples of rats and guinea pigs.	C2 Oral	Rat Guinea pig
Mracek 2014 Abstract MiP2014	Function of mitochondrial energy provision apparatus is compromised in patients with chronic heart failure. Mitochondr Physiol Network 19.13.	C4 P-flash	Human	Heart		Cardiovascular
Nagy 2014 Abstract MiP2014	Investigation of the energy metabolism of microglial cells.	C1 Poster	Human	Nervous system
Neufer 2014 Abstract MiP2014	Assessing ATP production and oxygen consumption simultaneously in permeabilized fibers: ATP/O.	A4 Oral	Mouse	Skeletal muscle
Oparka 2014 Abstract MiP2014	Investigation of the mitochondrial functions to understand p66Shc and reactive oxygen species interplay in tumor cells.	B2 Oral	Human		Oxidative stress;RONS	Cancer
Paju 2014 Abstract MiP2014	Characterization of the effects of pro-inflammatory cytokines on energy metabolism in human myoblasts.	C1 Oral	Human	Skeletal muscle		Aging;senescence
Pecina 2014 Abstract MiP2014	Manifestation of mitochondrial disorders of nuclear origin in lymphocytes.	C1 Oral	Human	Blood cells Lymphocyte
Perry 2014 Abstract MiP2014	Evaluation of critical experimental parameters for assessing mitochondrial bioenergetics in permeabilized myofibers.	B1 Oral	Human	Skeletal muscle
Pesta 2014 Abstract MiP 2014	Dysregulation of muscle ATP synthesis in hypophosphatemic mouse models and in a patient with hypophosphatemia due to a mutation in NaPi2c.	A1 Oral	Human Mouse	Skeletal muscle		Diabetes
Picard 2014 Abstract MiP2014	Quantitative regulation of nuclear gene expression by mitochondrial DNA heteroplasmy.	A1 Oral		Other cell lines
Power 2014 Abstract MiP2014	The hot heart: cardiac mitochondrial energetics during hyperthermia.	C4 Oral	Rat	Heart	Permeability transition Temperature
Purhonen 2014 Abstract MiP2014	Effect of ketogenic diet in mouse model of the mitochondrial hepatopathy GRACILE syndrome.
Rodrigues 2014 Abstract MiP2014	Bioenergetics’ traits of tongue cancer metastatic cells.	B3 Poster	Mouse	Lymphocyte		Cancer
Roy 2014 Abstract MiP2014	Differential expression of mitochondrial transporter proteins leads to incomplete fatty acid oxidation and insulin resistance in palmitate-treated muscle cells.	C3 Oral	Rat	Skeletal muscle		Diabetes
Schoepf 2014 Abstract MiP2014	OXPHOS analysis in small prostate biopsies.	A4 Oral	Human	Genital	Oxidative stress;RONS	Cancer
Shirihai 2014 Abstract MiP2014	Mitochondrial dynamics and quality control, a conflict of interest.	A2 Oral	Human	Fat		Aging;senescence Diabetes Obesity
Skulachev 2014 Abstract MiP2014	Mitochondria are sources, rather than sinks, of reactive oxygen species. Effects of mitochondria-targeted antioxidants.	B2 Oral	Mouse Rat		Oxidative stress;RONS	Aging;senescence Inherited
Sokolova 2014 Abstract MiP2014	Bioenergetic responses to cyclic hypoxia reveal mitochondrial mechanisms of hypoxia tolerance in marine bivalves.	B3 Oral	Other invertebrates		Ischemia-reperfusion Oxidative stress;RONS
Sparks 2014 Abstract MiP2014	NAMPT remodels substrate metabolism in skeletal muscle.	B1 Oral	Mouse	Skeletal muscle
Spendiff 2014 Abstract MiP2014	Lessons from the master athlete: mitochondrial contributions to aging.	A3 Oral	Human	Skeletal muscle	Oxidative stress;RONS	Aging;senescence
Starkov 2014 Abstract MiP2014	Mitochondria as H2O2 buffering system.	B2 Oral			Oxidative stress;RONS
Stiban 2014 Abstract MiP2014	Very long chain ceramides interfere with C16 ceramide-induced channel formation: rheostatic control of apoptosis.	C4 Oral			Cell death
Sumbalova 2014 Abstract MiP2014	Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.	B1 Oral	Rat	Nervous system Liver
Timon-Gomez 2014 Abstract MiP2014	The function of mitochondrial pyruvate carriers in the adaptation of respiration capacity and stress tolerance in yeast.	B3 P-flash	Saccharomyces cerevisiae		Oxidative stress;RONS
Tretter 2014 Abstract MiP2014	Cool or heat? Bioenergetic and ROS homeostatic approach to therapeutic hypothermia.	C4 Oral	Guinea pig	Nervous system	Oxidative stress;RONS Temperature
Trudeau 2014 Abstract MiP2014	Role of mitochondrial fusion and motility in distributing young mitochondrial protein and removing old protein from the mitochondrial network.	A2 P-flash
Volodina 2014 Abstract MiP2014	Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy.	B1 Oral	Rat	Liver	Oxidative stress;RONS
Widlund 2014 Abstract MiP2014	Resveratrol as a double edged sword on mitochondrial function.	B4 Oral		HeLa
Wieckowski 2014 Abstract MiP2014	Understanding the utility and limitations of autopsy samples for mitochondrial studies - evaluation of oxidative stress in the central nervous system of patients with diagnosed or highly probable mitochondrial diseases.	C4 P-flash	Mouse	Nervous system	Oxidative stress;RONS
Wohlwend 2014 Abstract MiP2014	Exercise modality specific mitochondrial adaptations in skeletal muscle of elderly people.	A3 Oral	Human	Skeletal muscle		Aging;senescence
Wojtala 2014 Abstract MiP2014	Proteomic analysis of mitochondrial Complex I deficient mouse model - impact of Complex I deficiency on p66Shc-Ser36 phosphorylation pathway in NDUFS4-/- mouse tissues.	A1 P-flash	Mouse		Oxidative stress;RONS
Zapisek 2014 Abstract MiP2014	YER077C encodes a novel PPR protein essential for mitochondrial genome expression in Saccharomyces cerevisiae.	A1 Poster	Saccharomyces cerevisiae
Zorzano 2014 Abstract MiP2014	Metabolic implications of mitofusin 2 dysfunction.	A2 Oral	Mouse	Skeletal muscle		Diabetes Obesity