Difference between revisions of "LEAK respiration"
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|abbr=''L'' | |abbr=''L'' | ||
|description='''LEAK respiration''' or LEAK oxygen flux, ''L'', compensating for proton leak, slip and cation cycling, is measured as mitochondrial respiration in the [[LEAK state]], in the presence of reducing substrate(s), but absence of inorganic phosphate or ADP, or after inhibition of the [[phosphorylation system]]. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined by the [[proton leak]] and the H<sup>+</sup>/O ratio. In this state of maximum protonmotive force, LEAK respiration is higher than the LEAK component in state ''P'' ([[OXPHOS capacity]]). | |description='''LEAK respiration''' or LEAK oxygen flux, ''L'', compensating for [[proton leak]], [[proton slip]] and cation cycling, is measured as mitochondrial respiration in the [[LEAK state]], in the presence of reducing substrate(s), but absence of inorganic phosphate or ADP, or after inhibition of the [[phosphorylation system]]. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined by the [[proton leak]] and the H<sup>+</sup>/O ratio. In this state of maximum protonmotive force, LEAK respiration is higher than the LEAK component in state ''P'' ([[OXPHOS capacity]]). | ||
|info=[http://www.oroboros.at/?Gnaiger_2012_MitoPathways Gnaiger 2012 MitoPathways], [[Gnaiger 2009 Int J Biochem Cell Biol]] | |info=[http://www.oroboros.at/?Gnaiger_2012_MitoPathways Gnaiger 2012 MitoPathways], [[Gnaiger 2009 Int J Biochem Cell Biol]] | ||
|type=Respiration | |type=Respiration | ||
Revision as of 13:04, 7 August 2013
- high-resolution terminology - matching measurements at high-resolution
LEAK respiration
Description
LEAK respiration or LEAK oxygen flux, L, compensating for proton leak, proton slip and cation cycling, is measured as mitochondrial respiration in the LEAK state, in the presence of reducing substrate(s), but absence of inorganic phosphate or ADP, or after inhibition of the phosphorylation system. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined by the proton leak and the H+/O ratio. In this state of maximum protonmotive force, LEAK respiration is higher than the LEAK component in state P (OXPHOS capacity).
Abbreviation: L
Reference: Gnaiger 2012 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory state"Respiratory state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
