Gnaiger 2023 MitoFit CII: Difference between revisions
No edit summary |
(:::::: 500px|link=Yuan 2022 Oxid Med Cell Longev :::: '''e''' Yuan Q, Zeng ZL, Yang S, Li A, Zu X, Liu J (2022) Mitochondrial stress in metabolic inflammation: modest benefits and full losses. Oxid Med Cell Longev 2022:8803404. - »Bioblast link« <br>) |
||
Line 17: | Line 17: | ||
__TOC__ | __TOC__ | ||
=== Supplement Figure S1 === | === Supplement Figure S1 === | ||
Line 31: | Line 23: | ||
:::::: [[File:Arnold, Finley 2022 CORRECTION.png|600px|link=Arnold 2023 J Biol Chem]] | :::::: [[File:Arnold, Finley 2022 CORRECTION.png|600px|link=Arnold 2023 J Biol Chem]] | ||
:::: '''a''' Arnold PK, Finley LWS (2023) Regulation and function of the mammalian tricarboxylic acid cycle. J Biol Chem 299:102838. - [[Arnold 2023 J Biol Chem |»Bioblast link«]] | :::: '''a''' Arnold PK, Finley LWS (2023) Regulation and function of the mammalian tricarboxylic acid cycle. J Biol Chem 299:102838. - [[Arnold 2023 J Biol Chem |»Bioblast link«]] | ||
<br> | |||
:::::: [[File:Jarmuszkiewicz 2023 Front Biosci CORRECTION.png|700px|link=Jarmuszkiewicz 2023 Front Biosci (Landmark Ed)]] | |||
:::: '''b''' Jarmuszkiewicz W, Dominiak K, Budzinska A, Wojcicki K, Galganski L (2023) Mitochondrial coenzyme Q redox homeostasis and reactive oxygen species production. Front Biosci (Landmark Ed) 28:61. - [[Jarmuszkiewicz 2023 Front Biosci (Landmark Ed) |»Bioblast link«]] | |||
<br> | <br> | ||
:::::: [[File:Chen 2022 Am J Physiol Cell Physiol CORRECTION.png|500px|link=Chen 2022 Am J Physiol Cell Physiol]] | :::::: [[File:Chen 2022 Am J Physiol Cell Physiol CORRECTION.png|500px|link=Chen 2022 Am J Physiol Cell Physiol]] | ||
:::: ''' | :::: '''c''' Chen CL, Zhang L, Jin Z, Kasumov T, Chen YR (2022) Mitochondrial redox regulation and myocardial ischemia-reperfusion injury. Am J Physiol Cell Physiol 322:C12-23. - [[Chen 2022 Am J Physiol Cell Physiol |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File: | :::::: [[File:Yuan 2022 Oxid Med Cell Longev CORRECTION.png|400px|link=Yuan 2022 Oxid Med Cell Longev]] | ||
:::: ''' | :::: '''d''' Yuan Q, Zeng ZL, Yang S, Li A, Zu X, Liu J (2022) Mitochondrial stress in metabolic inflammation: modest benefits and full losses. Oxid Med Cell Longev 2022:8803404. - [[Yuan 2022 Oxid Med Cell Longev |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Ahmad 2022 StatPearls CORRECTION.png|400px|link=Ahmad 2022 StatPearls Publishing]] | :::::: [[File:Ahmad 2022 StatPearls CORRECTION.png|400px|link=Ahmad 2022 StatPearls Publishing]] | ||
:::: ''' | :::: '''e''' Ahmad M, Wolberg A, Kahwaji CI (2022) Biochemistry, electron transport chain. StatPearls Publishing StatPearls [Internet]. Treasure Island (FL) - [[Ahmad 2022 StatPearls Publishing |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File: | :::::: [[File:Turton 2022 Int J Mol Sci CORRECTION.png|500px|link=Turton 2022 Int J Mol Sci]] | ||
:::: ''' | :::: '''f''' Turton N, Cufflin N, Dewsbury M, Fitzpatrick O, Islam R, Watler LL, McPartland C, Whitelaw S, Connor C, Morris C, Fang J, Gartland O, Holt L, Hargreaves IP (2022) The biochemical assessment of mitochondrial respiratory chain disorders. Int J Mol Sci 23:7487. - [[Turton 2022 Int J Mol Sci |»Bioblast link«]] | ||
<br> | <br> | ||
:::: [[File:Chandel 2021 Cold Spring Harb Perspect Biol CORRECTION.png|1000px|link=Chandel 2021 Cold Spring Harb Perspect Biol]] | :::: [[File:Chandel 2021 Cold Spring Harb Perspect Biol CORRECTION.png|1000px|link=Chandel 2021 Cold Spring Harb Perspect Biol]] | ||
:::: ''' | :::: '''g''' Chandel NS (2021) Mitochondria. Cold Spring Harb Perspect Biol 13:a040543. - [[Chandel 2021 Cold Spring Harb Perspect Biol |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Yin 2021 FASEB J CORRECTION.png|500px|link=Yin 2021 FASEB J]] | :::::: [[File:Yin 2021 FASEB J CORRECTION.png|500px|link=Yin 2021 FASEB J]] | ||
:::: ''' | :::: '''h''' Yin M, O'Neill LAJ (2021) The role of the electron transport chain in immunity. FASEB J 35:e21974. - [[Yin 2021 FASEB J |»Bioblast link«]] | ||
:::::: [[File:Missaglia 2021 CORRECTION.png|500px|link=Missaglia 2021 Crit Rev Biochem Mol Biol]] | :::::: [[File:Missaglia 2021 CORRECTION.png|500px|link=Missaglia 2021 Crit Rev Biochem Mol Biol]] | ||
:::: ''' | :::: '''i''' Missaglia S, Tavian D, Angelini C (2021) ETF dehydrogenase advances in molecular genetics and impact on treatment. Crit Rev Biochem Mol Biol 56:360-72. - [[Missaglia 2021 Crit Rev Biochem Mol Biol |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Gasmi 2021 Arch Toxicol CORRECTION.png|500px|link=Gasmi 2021 Arch Toxicol]] | :::::: [[File:Gasmi 2021 Arch Toxicol CORRECTION.png|500px|link=Gasmi 2021 Arch Toxicol]] | ||
:::: ''' | :::: '''j''' Gasmi A, Peana M, Arshad M, Butnariu M, Menzel A, Bjørklund G (2021) Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis. Arch Toxicol 95:1161-78. - [[Gasmi 2021 Arch Toxicol |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Turton 2021 Expert Opinion Orphan Drugs CORRECTION.png|400px|link=Turton 2021 Expert Opinion Orphan Drugs]] | :::::: [[File:Turton 2021 Expert Opinion Orphan Drugs CORRECTION.png|400px|link=Turton 2021 Expert Opinion Orphan Drugs]] | ||
:::: ''' | :::: '''k''' Turton N, Bowers N, Khajeh S, Hargreaves IP, Heaton RA (2021) Coenzyme Q10 and the exclusive club of diseases that show a limited response to treatment. Expert Opinion on Orphan Drugs 9:151-60. - [[Turton 2021 Expert Opinion Orphan Drugs |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Martinez-Reyes, Chandel 2020 CORRECTION.png|600px|link=Martinez-Reyes 2020 Nat Commun]] | :::::: [[File:Martinez-Reyes, Chandel 2020 CORRECTION.png|600px|link=Martinez-Reyes 2020 Nat Commun]] | ||
:::: ''' | :::: '''l''' Martínez-Reyes I, Chandel NS (2020) Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun 11:102. - [[Martinez-Reyes 2020 Nat Commun |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Raimondi 2020 Br J Cancer CORRECTION.png|400px|link=Raimondi 2020 Br J Cancer]] | :::::: [[File:Raimondi 2020 Br J Cancer CORRECTION.png|400px|link=Raimondi 2020 Br J Cancer]] | ||
:::: ''' | :::: '''m''' Raimondi V, Ciccarese F, Ciminale V (2020) Oncogenic pathways and the electron transport chain: a dangeROS liaison. Br J Cancer 122:168-81. - [[Raimondi 2020 Br J Cancer |»Bioblast link«]] | ||
<br> | |||
:::::: [[File:Risiglione 2020 Int J Mol Sci CORRECTION.png|500px|link=Risiglione 2020 Int J Mol Sci]] | |||
:::: '''n''' Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. - [[Risiglione 2020 Int J Mol Sci |»Bioblast link«]] | |||
<br> | <br> | ||
:::::: [[File:Morelli 2019 Open Biol CORRECTION.png|500px|link=Morelli 2019 Open Biol]] | :::::: [[File:Morelli 2019 Open Biol CORRECTION.png|500px|link=Morelli 2019 Open Biol]] | ||
:::: ''' | :::: '''o''' Morelli AM, Ravera S, Calzia D, Panfoli I (2019) An update of the chemiosmotic theory as suggested by possible proton currents inside the coupling membrane. Open Biol 9:180221. - [[Morelli 2019 Open Biol |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Lewis 2019 CORRECTION.png|500px|link=Lewis 2019 Int J Mol Sci]] | :::::: [[File:Lewis 2019 CORRECTION.png|500px|link=Lewis 2019 Int J Mol Sci]] | ||
:::: ''' | :::: '''p''' Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Quantification of mitochondrial oxidative phosphorylation in metabolic disease: application to Type 2 diabetes. Int J Mol Sci 20:5271. - [[Lewis 2019 Int J Mol Sci |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Sarmah 2019 Transl Stroke Res CORRECTION.png|500px|link=Sarmah 2019 Transl Stroke Res]] | :::::: [[File:Sarmah 2019 Transl Stroke Res CORRECTION.png|500px|link=Sarmah 2019 Transl Stroke Res]] | ||
:::: ''' | :::: '''q''' Sarmah D, Kaur H, Saraf J, Vats K, Pravalika K, Wanve M, Kalia K, Borah A, Kumar A, Wang X, Yavagal DR, Dave KR, Bhattacharya P (2019) Mitochondrial dysfunction in stroke: implications of stem cell therapy. Transl Stroke Res doi: 10.1007/s12975-018-0642-y - [[Sarmah 2019 Transl Stroke Res |»Bioblast link«]] | ||
:::::: [[File:Yepez 2018 PLOS One Fig1B.jpg|300px|link=Yepez 2018 PLOS One]] | :::::: [[File:Yepez 2018 PLOS One Fig1B.jpg|300px|link=Yepez 2018 PLOS One]] | ||
:::: ''' | :::: '''r''' Yépez VA, Kremer LS, Iuso A, Gusic M, Kopajtich R, Koňaříková E, Nadel A, Wachutka L, Prokisch H, Gagneur J (2018) OCR-Stats: Robust estimation and statistical testing of mitochondrial respiration activities using Seahorse XF Analyzer. PLOS ONE 13:e0199938. - [[Yepez 2018 PLOS One |»Bioblast link«]] | ||
<br> | |||
:::::: [[File:Zhang 2018 Mil Med Res CORRECTION.png|400px|link=Zhang 2018 Mil Med Res]] | |||
:::: '''s''' Zhang H, Feng YW, Yao YM (2018) Potential therapy strategy: targeting mitochondrial dysfunction in sepsis. Mil Med Res 5:41. - [[Zhang 2018 Mil Med Res |»Bioblast link«]] | |||
<br> | <br> | ||
:::::: [[File:Chowdhury 2018 Oxid Med Cell Longev CORRECTION.png|400px|link=Chowdhury 2018 Oxid Med Cell Longev]] | :::::: [[File:Chowdhury 2018 Oxid Med Cell Longev CORRECTION.png|400px|link=Chowdhury 2018 Oxid Med Cell Longev]] | ||
:::: ''' | :::: '''t''' Roy Chowdhury S, Banerji V (2018) Targeting mitochondrial bioenergetics as a therapeutic strategy for chronic lymphocytic leukemia. Oxid Med Cell Longev 2018:2426712. - [[Chowdhury 2018 Oxid Med Cell Longev |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:De Villiers 2018 Adv Exp Med Biol CORRECTION.png|400px|link=De Villiers 2018 Adv Exp Med Biol]] | :::::: [[File:De Villiers 2018 Adv Exp Med Biol CORRECTION.png|400px|link=De Villiers 2018 Adv Exp Med Biol]] | ||
:::: ''' | :::: '''u''' de Villiers D, Potgieter M, Ambele MA, Adam L, Durandt C, Pepper MS (2018) The role of reactive oxygen species in adipogenic differentiation. Adv Exp Med Biol 1083:125-144. - [[De Villiers 2018 Adv Exp Med Biol |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Polyzos 2017 Mech Ageing Dev CORRECTION.png|400px|link=Polyzos 2017 Mech Ageing Dev]] | :::::: [[File:Polyzos 2017 Mech Ageing Dev CORRECTION.png|400px|link=Polyzos 2017 Mech Ageing Dev]] | ||
:::: ''' | :::: '''v''' Polyzos AA, McMurray CT (2017) The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease. Mech Ageing Dev 161:181-97. - [[Polyzos 2017 Mech Ageing Dev |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Jones, Bennett 2017 Chapter 4 CORRECTION.png|400px|link=Jones 2017 Elsevier]] | :::::: [[File:Jones, Bennett 2017 Chapter 4 CORRECTION.png|400px|link=Jones 2017 Elsevier]] | ||
:::: ''' | :::: '''w''' Jones PM, Bennett MJ (2017) Chapter 4 - Disorders of mitochondrial fatty acid β-oxidation. Elsevier In: Garg U, Smith LD , eds. Biomarkers in inborn errors of metabolism. Clinical aspects and laboratory determination:87-101. - [[Jones 2017 Elsevier |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:DeBerardinis, Chandel 2016 CORRECTION.png|600px|link=DeBerardinis 2016 Sci Adv]] | :::::: [[File:DeBerardinis, Chandel 2016 CORRECTION.png|600px|link=DeBerardinis 2016 Sci Adv]] | ||
:::: ''' | :::: '''x''' DeBerardinis RJ, Chandel NS (2016) Fundamentals of cancer metabolism. Sci Adv 2:e1600200. - [[DeBerardinis 2016 Sci Adv |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Nsiah-Sefaa 2016 Bioscie Reports CORRECTION.png|600px|link=Nsiah-Sefaa 2016 Biosci Rep]] | :::::: [[File:Nsiah-Sefaa 2016 Bioscie Reports CORRECTION.png|600px|link=Nsiah-Sefaa 2016 Biosci Rep]] | ||
:::: ''' | :::: '''y''' Nsiah-Sefaa A, McKenzie M (2016) Combined defects in oxidative phosphorylation and fatty acid β-oxidation in mitochondrial disease. Biosci Rep 36:e00313. - [[Nsiah-Sefaa 2016 Biosci Rep |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Prochaska 2013 Springer CORRECTION.png|400px|link=Prochaska 2013 Springer]] | :::::: [[File:Prochaska 2013 Springer CORRECTION.png|400px|link=Prochaska 2013 Springer]] | ||
:::: ''' | :::: '''z''' Prochaska LJ, Cvetkov TL (2013) Mitochondrial electron transport. In: Roberts, G.C.K. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16712-6_25 - [[Prochaska 2013 Springer |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Fisher-Wellman 2012 Trends Endocrinol Metab CORRECTION.png|400px|link=Fisher-Wellman 2012 Trends Endocrinol Metab]] [[File:Fisher-Wellman 2012 Trends Endocrinol Metab Fig2 CORRECTION.png|400px|link=Fisher-Wellman 2012 Trends Endocrinol Metab]] | :::::: [[File:Fisher-Wellman 2012 Trends Endocrinol Metab CORRECTION.png|400px|link=Fisher-Wellman 2012 Trends Endocrinol Metab]] [[File:Fisher-Wellman 2012 Trends Endocrinol Metab Fig2 CORRECTION.png|400px|link=Fisher-Wellman 2012 Trends Endocrinol Metab]] | ||
:::: ''' | :::: '''α,β''' Fisher-Wellman KH, Neufer PD (2012) Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol Metab 23:142-53. - [[Fisher-Wellman 2012 Trends Endocrinol Metab |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Benard 2011 Springer CORRECTION.png|500px|link=Benard 2011 Springer]] | :::::: [[File:Benard 2011 Springer CORRECTION.png|500px|link=Benard 2011 Springer]] | ||
:::: ''' | :::: '''γ''' Benard G, Bellance N, Jose C, Rossignol R (2011) Relationships between mitochondrial dynamics and bioenergetics. In: Lu Bingwei (ed) Mitochondrial dynamics and neurodegeneration. Springer ISBN 978-94-007-1290-4:47-68. - [[Benard 2011 Springer |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Nussbaum 2005 J Clin Invest CORRECTION.png|500px|link=Nussbaum 2005 J Clin Invest]] | :::::: [[File:Nussbaum 2005 J Clin Invest CORRECTION.png|500px|link=Nussbaum 2005 J Clin Invest]] | ||
:::: ''' | :::: '''δ''' Nussbaum RL (2005) Mining yeast in silico unearths a golden nugget for mitochondrial biology. J Clin Invest 115:2689-91. - [[Nussbaum 2005 J Clin Invest |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File: | :::::: [[File:Himms-Hagen, Harper 2001 CORRECTION.png|250px|link=Himms-Hagen 2001 Exp Biol Med (Maywood)]] | ||
:::: ''' | :::: '''ε''' Himms-Hagen J, Harper ME (2001) Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med (Maywood) 226:78-84. - [[Himms-Hagen 2001 Exp Biol Med (Maywood) |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File: | :::::: [[File:Sanchez et al 2001 CORRECTION.png|600px|link=Sanchez 2001 Br J Pharmacol]] | ||
:::: ''' | :::: '''ζ''' Sanchez H, Zoll J, Bigard X, Veksler V, Mettauer B, Lampert E, Lonsdorfer J, Ventura-Clapier R (2001) Effect of cyclosporin A and its vehicle on cardiac and skeletal muscle mitochondria: relationship to efficacy of the respiratory chain. Br J Pharmacol 133:781-8. - [[Sanchez 2001 Br J Pharmacol |»Bioblast link«]] | ||
<br> | <br> | ||
:::::: [[File:Brownlee 2001 Nature CORRECTION.png|400px|link=Brownlee 2001 Nature]] | :::::: [[File:Brownlee 2001 Nature CORRECTION.png|400px|link=Brownlee 2001 Nature]] | ||
:::: ''' | :::: '''η''' Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 14:813-20. - [[Brownlee 2001 Nature |»Bioblast link«]] | ||
:::: Ref. [34] Arden GB, Ramsey DJ (2015) Diabetic retinopathy and a novel treatment based on the biophysics of rod photoreceptors and dark adaptation. Webvision In: Kolb H, Fernandez E, Nelson R, eds. Webvision: The organization of the retina and visual system [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-. - [[Arden 2015 Webvision |»Bioblast link«]] | :::: Ref. [34] Arden GB, Ramsey DJ (2015) Diabetic retinopathy and a novel treatment based on the biophysics of rod photoreceptors and dark adaptation. Webvision In: Kolb H, Fernandez E, Nelson R, eds. Webvision: The organization of the retina and visual system [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-. - [[Arden 2015 Webvision |»Bioblast link«]] | ||
<br> | <br> |
Revision as of 12:08, 2 April 2023
Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. MitoFit Preprints 2023.3. https://doi.org/10.26124/mitofit:2023-0003 |
» MitoFit Preprints 2023.3.
Complex II ambiguities ― FADH2 in the electron transfer system
Gnaiger Erich (2023) MitoFit Prep
Abstract:
The current narrative that the reduced coenzymes NADH and FADH2 feed electrons from the tricarboxylic acid (TCA) cycle into the mitochondrial electron transfer system can create ambiguities around respiratory Complex CII. Succinate dehydrogenase or CII reduces FAD to FADH2 in the canonical forward TCA cycle. However, some graphical representations of the membrane-bound electron transfer system (ETS) depict CII as the site of oxidation of FADH2. This leads to the false believe that FADH2 generated by electron transferring flavoprotein (CETF) in fatty acid oxidation and mitochondrial glycerophosphate dehydrogenase (CGpDH) feeds electrons into the ETS through CII. In reality, NADH and succinate produced in the TCA cycle are the substrates of Complexes CI and CII, respectively, and the reduced flavin groups FMNH2 and FADH2 are downstream products of CI and CII, respectively, carrying electrons from CI and CII into the Q-junction. Similarly, CETF and CGpDH feed electrons into the Q-junction but not through CII. The ambiguities surrounding Complex II in the literature call for quality control, to secure scientific standards in current communications on bioenergetics and support adequate clinical applications.
• Keywords: coenzyme Q junction; Complex CII; electron transfer system; fatty acid oxidation; flavin adenine dinucleotide;
succinate dehydrogenase; tricarboxylic acid cycle
• O2k-Network Lab: AT Innsbruck Oroboros
ORCID: Gnaiger Erich, Oroboros Instruments, Innsbruck, Austria
- Acknowledgements: I thank Luiza H. Cardoso and Sabine Schmitt for stimulating discussions, and Paolo Cocco for expert help on the graphical abstract and Figure 1c. Contribution to the European Union’s Horizon 2020 research and innovation program Grant 857394 (FAT4BRAIN).
Supplement Figure S1
- Figure S1. Complex II ambiguities in graphical representations on FADH2 as a substrate of Complex II in the canonical forward electron transfer. Chronological sequence of publications from 2001 to 2023.
- a Arnold PK, Finley LWS (2023) Regulation and function of the mammalian tricarboxylic acid cycle. J Biol Chem 299:102838. - »Bioblast link«
- b Jarmuszkiewicz W, Dominiak K, Budzinska A, Wojcicki K, Galganski L (2023) Mitochondrial coenzyme Q redox homeostasis and reactive oxygen species production. Front Biosci (Landmark Ed) 28:61. - »Bioblast link«
- c Chen CL, Zhang L, Jin Z, Kasumov T, Chen YR (2022) Mitochondrial redox regulation and myocardial ischemia-reperfusion injury. Am J Physiol Cell Physiol 322:C12-23. - »Bioblast link«
- d Yuan Q, Zeng ZL, Yang S, Li A, Zu X, Liu J (2022) Mitochondrial stress in metabolic inflammation: modest benefits and full losses. Oxid Med Cell Longev 2022:8803404. - »Bioblast link«
- e Ahmad M, Wolberg A, Kahwaji CI (2022) Biochemistry, electron transport chain. StatPearls Publishing StatPearls [Internet]. Treasure Island (FL) - »Bioblast link«
- f Turton N, Cufflin N, Dewsbury M, Fitzpatrick O, Islam R, Watler LL, McPartland C, Whitelaw S, Connor C, Morris C, Fang J, Gartland O, Holt L, Hargreaves IP (2022) The biochemical assessment of mitochondrial respiratory chain disorders. Int J Mol Sci 23:7487. - »Bioblast link«
- g Chandel NS (2021) Mitochondria. Cold Spring Harb Perspect Biol 13:a040543. - »Bioblast link«
- h Yin M, O'Neill LAJ (2021) The role of the electron transport chain in immunity. FASEB J 35:e21974. - »Bioblast link«
- i Missaglia S, Tavian D, Angelini C (2021) ETF dehydrogenase advances in molecular genetics and impact on treatment. Crit Rev Biochem Mol Biol 56:360-72. - »Bioblast link«
- j Gasmi A, Peana M, Arshad M, Butnariu M, Menzel A, Bjørklund G (2021) Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis. Arch Toxicol 95:1161-78. - »Bioblast link«
- k Turton N, Bowers N, Khajeh S, Hargreaves IP, Heaton RA (2021) Coenzyme Q10 and the exclusive club of diseases that show a limited response to treatment. Expert Opinion on Orphan Drugs 9:151-60. - »Bioblast link«
- l Martínez-Reyes I, Chandel NS (2020) Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun 11:102. - »Bioblast link«
- m Raimondi V, Ciccarese F, Ciminale V (2020) Oncogenic pathways and the electron transport chain: a dangeROS liaison. Br J Cancer 122:168-81. - »Bioblast link«
- n Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. - »Bioblast link«
- o Morelli AM, Ravera S, Calzia D, Panfoli I (2019) An update of the chemiosmotic theory as suggested by possible proton currents inside the coupling membrane. Open Biol 9:180221. - »Bioblast link«
- p Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Quantification of mitochondrial oxidative phosphorylation in metabolic disease: application to Type 2 diabetes. Int J Mol Sci 20:5271. - »Bioblast link«
- q Sarmah D, Kaur H, Saraf J, Vats K, Pravalika K, Wanve M, Kalia K, Borah A, Kumar A, Wang X, Yavagal DR, Dave KR, Bhattacharya P (2019) Mitochondrial dysfunction in stroke: implications of stem cell therapy. Transl Stroke Res doi: 10.1007/s12975-018-0642-y - »Bioblast link«
- r Yépez VA, Kremer LS, Iuso A, Gusic M, Kopajtich R, Koňaříková E, Nadel A, Wachutka L, Prokisch H, Gagneur J (2018) OCR-Stats: Robust estimation and statistical testing of mitochondrial respiration activities using Seahorse XF Analyzer. PLOS ONE 13:e0199938. - »Bioblast link«
- s Zhang H, Feng YW, Yao YM (2018) Potential therapy strategy: targeting mitochondrial dysfunction in sepsis. Mil Med Res 5:41. - »Bioblast link«
- t Roy Chowdhury S, Banerji V (2018) Targeting mitochondrial bioenergetics as a therapeutic strategy for chronic lymphocytic leukemia. Oxid Med Cell Longev 2018:2426712. - »Bioblast link«
- u de Villiers D, Potgieter M, Ambele MA, Adam L, Durandt C, Pepper MS (2018) The role of reactive oxygen species in adipogenic differentiation. Adv Exp Med Biol 1083:125-144. - »Bioblast link«
- v Polyzos AA, McMurray CT (2017) The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease. Mech Ageing Dev 161:181-97. - »Bioblast link«
- w Jones PM, Bennett MJ (2017) Chapter 4 - Disorders of mitochondrial fatty acid β-oxidation. Elsevier In: Garg U, Smith LD , eds. Biomarkers in inborn errors of metabolism. Clinical aspects and laboratory determination:87-101. - »Bioblast link«
- x DeBerardinis RJ, Chandel NS (2016) Fundamentals of cancer metabolism. Sci Adv 2:e1600200. - »Bioblast link«
- y Nsiah-Sefaa A, McKenzie M (2016) Combined defects in oxidative phosphorylation and fatty acid β-oxidation in mitochondrial disease. Biosci Rep 36:e00313. - »Bioblast link«
- z Prochaska LJ, Cvetkov TL (2013) Mitochondrial electron transport. In: Roberts, G.C.K. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16712-6_25 - »Bioblast link«
- α,β Fisher-Wellman KH, Neufer PD (2012) Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol Metab 23:142-53. - »Bioblast link«
- γ Benard G, Bellance N, Jose C, Rossignol R (2011) Relationships between mitochondrial dynamics and bioenergetics. In: Lu Bingwei (ed) Mitochondrial dynamics and neurodegeneration. Springer ISBN 978-94-007-1290-4:47-68. - »Bioblast link«
- δ Nussbaum RL (2005) Mining yeast in silico unearths a golden nugget for mitochondrial biology. J Clin Invest 115:2689-91. - »Bioblast link«
- ε Himms-Hagen J, Harper ME (2001) Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med (Maywood) 226:78-84. - »Bioblast link«
- ζ Sanchez H, Zoll J, Bigard X, Veksler V, Mettauer B, Lampert E, Lonsdorfer J, Ventura-Clapier R (2001) Effect of cyclosporin A and its vehicle on cardiac and skeletal muscle mitochondria: relationship to efficacy of the respiratory chain. Br J Pharmacol 133:781-8. - »Bioblast link«
- η Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 14:813-20. - »Bioblast link«
- Ref. [34] Arden GB, Ramsey DJ (2015) Diabetic retinopathy and a novel treatment based on the biophysics of rod photoreceptors and dark adaptation. Webvision In: Kolb H, Fernandez E, Nelson R, eds. Webvision: The organization of the retina and visual system [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-. - »Bioblast link«
Supplement Figure S2
- Figure S2. Complex II ambiguities in graphical representations on FADH2 as a substrate of Complex II in the canonical forward electron transfer.
- Website 1: OpenStax Biology - Fig. 7.10 Oxidative phosphorylation (CC BY 3.0). - OpenStax Biology got it wrong in figures and text. The error is copied without quality assessment and propagated in several links.
- Website 2: Concepts of Biology - 1st Canadian Edition by Charles Molnar and Jane Gair - Fig. 4.19a
- Website 3: LibreTexts Biology - Figure 7.11.1
- Website 4: lumen Biology for Majors I - Fig. 1
- Website 5: Pharmaguideline
- Website 6: Khan Academy - Image modified from "Oxidative phosphorylation: Figure 1", by OpenStax College, Biology (CC BY 3.0). Figure and text underscore the FADH2-error: "FADH2 .. feeds them (electrons) into the transport chain through complex II."
- Website 7: Saylor Academy
- Website 8: Jack Westin MCAT Courses
- Website 1: OpenStax Biology - Fig. 7.12
- Website 6: Khan Academy - Image modified from "Oxidative phosphorylation: Figure 3," by Openstax College, Biology (CC BY 3.0)
- Website 7: Saylor Academy
- Website 9: expii - Image source: By CNX OpenStax
- Website 10: Labxchange - Figure 8.15 credit: modification of work by Klaus Hoffmeier
- Website 4: lumen Biology for Majors I - Fig. 3
- Website 9: expii - By OpenStax College CC BY 3.0, via Wikimedia Commons
- Website 11: wikimedia 30148497 - Anatomy & Physiology, Connexions Web site. http://cnx.org/content/col11496/1.6/, 2013-06-19
- Website 12: biologydictionary.net 2018-08-21
- Website 13: Quora
- Website 14: TeachMePhysiology - Fig. 1. 2023-03-13
- Website 15: ThoughtCo
- Website 16: toppr
- Website 17: researchtweet
- Website 18: Microbe Notes
- Website 19: BiochemDen.com
- Website 20: dreamstime
- Website 21: VectorMine
- Website 22: creative-biolabs
- Website 6: Khan Academy
- Website 7: Saylor Academy
- Website 9: expii - Whitney, Rolfes 2002
- Website 23: FlexBooks - CK-12 Biology for High School- 2.28 Electron Transport, Figure 2
- Website 24: hyperphysics
- Website 25: Labster Theory
- Website 26: nau.edu
- Website 27: Quizlet
- Website 28: ScienceDirect
- Website 29: ScienceFacts
- Website 30: SNC1D - BIOLOGY LESSON PLAN BLOG
- Website 31: unm.edu
- Website 33: YouTube Dirty Medicine Biochemistry - Uploaded 2019-07-18
- Website 34: YouTube sciencemusicvideos - Uploaded 2014-08-19
- Website 15: ThoughtCo - extender01 / iStock / Getty Images Plus
- Website 17: dreamstime
Labels:
FAT4BRAIN