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Difference between revisions of "Gnaiger 2000 Transplant Proc"

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{{Publication
{{Publication
|title=Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Tranplant. Proc. 32: 14.
|title=Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant Proc 32:14.
|authors=Gnaiger E, Kuznetsov AV, Koenigsrainer A, Margreiter R  
|info=[http://www.ncbi.nlm.nih.gov/pubmed/10700947 PMID: 10700947]
|authors=Gnaiger Erich, Kuznetsov AV, Koenigsrainer A, Margreiter R
|year=2000
|year=2000
|journal=Tranplant. Proc.
|journal=Transplant Proc
|mipnetlab=AT_Innsbruck_GnaigerE
|abstract=AUTOOXIDATION reactions of highly reduced organic compounds are a source of reactive oxygen species that contribute to ischemia/reperfusion injury. Antioxidants such as reduced glutathione (GSH; g-glutamylcysteinylglycine) are added to organ preservation solutions to reduce oxidative stress.<sup>1,2</sup> GSH is unstable, however, in University of Wisconsin (UW) solution in the presence of oxygen.<sup>3</sup> To our knowledge, no reports are available on the stability of GSH in other organ preservation solutions, such as histidine-tryptophan-ketoglutarate (HTK) or Celsior solution. The present study reports for the first time a quantitative comparison of autooxidation of GSH in a variety of established preservation solutions, demonstrating in particular the high stability of GSH in HTK solution.
|abstract=AUTOOXIDATION reactions of highly reduced organic compounds are a source of reactive oxygen species that contribute to ischemia/reperfusion injury. Antioxidants such as reduced glutathione (GSH; g-glutamylcysteinylglycine)
|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck Oroboros
are added to organ preservation solutions to reduce oxidative stress.1,2 GSH is unstable, however, in University of Wisconsin (UW) solution in the presence of
|discipline=Biomedicine, Pharmacology; Biotechnology
oxygen.3 To our knowledge, no reports are available on the stability of GSH in other organ preservation solutions, such as histidine-tryptophan-ketoglutarate (HTK) or Celsior solution. The present study reports for the first time a
quantitative comparison of autooxidation of GSH in a variety of established preservation solutions, demonstrating in particular the high stability of GSH in HTK solution.
|info=[http://www.ncbi.nlm.nih.gov/pubmed/10700947 PMID: 10700947]
}}
}}
{{Labeling
{{Labeling
|area=Pharmacology;toxicology
|preparations=Oxidase;biochemical oxidation
|injuries=Ischemia-reperfusion, Oxidative stress;RONS
|topics=Oxygen kinetics, pH, Substrate, Temperature
|instruments=Oxygraph-2k
|instruments=Oxygraph-2k
|discipline=Biomedicine, Pharmacology; Biotechnology
|discipline=Biomedicine, Pharmacology; Biotechnology
|preparations=Oxidase; Biochemical Oxidation
|injuries=Ischemia-Reperfusion; Preservation
|kinetics=Oxygen, Temperature, pH
}}
}}

Latest revision as of 12:28, 2 May 2021

Publications in the MiPMap
Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant Proc 32:14.

» PMID: 10700947

Gnaiger Erich, Kuznetsov AV, Koenigsrainer A, Margreiter R (2000) Transplant Proc

Abstract: AUTOOXIDATION reactions of highly reduced organic compounds are a source of reactive oxygen species that contribute to ischemia/reperfusion injury. Antioxidants such as reduced glutathione (GSH; g-glutamylcysteinylglycine) are added to organ preservation solutions to reduce oxidative stress.1,2 GSH is unstable, however, in University of Wisconsin (UW) solution in the presence of oxygen.3 To our knowledge, no reports are available on the stability of GSH in other organ preservation solutions, such as histidine-tryptophan-ketoglutarate (HTK) or Celsior solution. The present study reports for the first time a quantitative comparison of autooxidation of GSH in a variety of established preservation solutions, demonstrating in particular the high stability of GSH in HTK solution.


O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Oroboros


Labels: MiParea: Pharmacology;toxicology 

Stress:Ischemia-reperfusion, Oxidative stress;RONS 


Preparation: Oxidase;biochemical oxidation 

Regulation: Oxygen kinetics, pH, Substrate, Temperature 


HRR: Oxygraph-2k