- high-resolution terminology - matching measurements at high-resolution
Glycerophosphate pathway control state
Description
Gp: The glycero-phosphate shuttle represents an important pathway, particularly in liver, of making cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer system at the level of CoQ.
Abbreviation: Gp
Reference: Gnaiger 2014 MitoPathways - Chapter 4.4
MitoPedia topics: "Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory substrate-coupling state"Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Gp(L)
Gp(P)
Gp(E)
Details
Glycerophosphate oxidation is 10-fold higher in rabbit gracilis mitochondria (fast-twitch white muscle; 99% type IIb) compared to soleus (slow-twitch red muscle; 98% type I). Activity is comparatively low in human vastus lateralis. Glycerophosphate is an important substrate for respiration in brown adipose tissue mitochondria.
