Difference between revisions of "Glycerophosphate"
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{{MitoPedia | {{MitoPedia | ||
|abbr=Gp | |abbr=Gp | ||
|description='''Glycerophosphate''' (synonym: Ī±-glycerophosphate; glycerol-3-phosphate; C<sub>3</sub>H<sub>9</sub>O<sub>6</sub>P) is an organophosphate and it is a component of glycerophospholipids. | |description='''Glycerophosphate''' (synonym: Ī±-glycerophosphate; glycerol-3-phosphate; C<sub>3</sub>H<sub>9</sub>O<sub>6</sub>P) is an organophosphate and it is a component of glycerophospholipids. Ā | ||
Ā | |||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
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'' | == Nomenclature issues == | ||
Ā | |||
Due to an ambiguity in the D, L nomenclature based on the FisherĀ projection the biologically active enantiomer can be labeled eitherĀ D-glycerol 1-phosphate or L-glycerol 3-phosphate. Alternatives are''sn''-glycerol 3-phosphate or DL-alpha-glycerophosphate.Ā Following the CahnāIngoldāPrelog priorityĀ rules the biologically active substance is always the (R) enantiomer,Ā independent of whether the substance is calledĀ glycerol 1-phosphate orĀ glycerol 3-phosphate. | |||
Ā | |||
== Availability == | |||
Ā | |||
''Sigma does not sell DL-alpha-glycerophosphate disodium salt hexahydrate (FW = 324.1; Sigma G-2138) any more (personal communication with [[Drahota Z|Dr. Zdenek Drahota]], Dept. of Bioenergetics, Institute of Physiology, Academy of Sciences of the Czech Rep.)!'' | ''Sigma does not sell DL-alpha-glycerophosphate disodium salt hexahydrate (FW = 324.1; Sigma G-2138) any more (personal communication with [[Drahota Z|Dr. Zdenek Drahota]], Dept. of Bioenergetics, Institute of Physiology, Academy of Sciences of the Czech Rep.)!'' | ||
[In Dr. Drahota's lab a 1 M stock solution is used and the final concentration inĀ the O2k-chamber is 10 mM.] | [In Dr. Drahota's lab a 1 M stock solution is used and the final concentration inĀ the O2k-chamber is 10 mM.] | ||
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Alternatives: | Alternatives: | ||
* | * enantiopure lithium salt: Sigma: 94124 | ||
Revision as of 13:30, 22 January 2014
- high-resolution terminology - matching measurements at high-resolution
Glycerophosphate
Description
Glycerophosphate (synonym: Ī±-glycerophosphate; glycerol-3-phosphate; C3H9O6P) is an organophosphate and it is a component of glycerophospholipids.
Abbreviation: Gp
MitoPedia topics: Substrate and metabolite
Glycerophosphate feeds electrons directly to ubiquinone and glycerophosphate dehydrogenase oxidizes glycerophosphate to dihydroxyacetone phosphate. See also glycerol phosphate shuttle.
Nomenclature issues
Due to an ambiguity in the D, L nomenclature based on the Fisher projection the biologically active enantiomer can be labeled either D-glycerol 1-phosphate or L-glycerol 3-phosphate. Alternatives aresn-glycerol 3-phosphate or DL-alpha-glycerophosphate. Following the CahnāIngoldāPrelog priority rules the biologically active substance is always the (R) enantiomer, independent of whether the substance is called glycerol 1-phosphate or glycerol 3-phosphate.
Availability
Sigma does not sell DL-alpha-glycerophosphate disodium salt hexahydrate (FW = 324.1; Sigma G-2138) any more (personal communication with Dr. Zdenek Drahota, Dept. of Bioenergetics, Institute of Physiology, Academy of Sciences of the Czech Rep.)! [In Dr. Drahota's lab a 1 M stock solution is used and the final concentration in the O2k-chamber is 10 mM.]
Search for an adequate replacement is underway.
Alternatives:
- enantiopure lithium salt: Sigma: 94124
