Difference between revisions of "GM-pathway control state"
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|description='''GM''': [[Glutamate]] & [[Malate]]. | |description=[[File:GM.jpg|left|200px|GM]] '''GM''': [[Glutamate]] & [[Malate]]. | ||
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When glutamate&malate are added to isolated mitochondria or permeabilized cells, glutamate and transaminase are responsible for the metabolism of [[oxaloacetate]], comparable to the metabolism with acetyl-CoA and citrate synthase | When glutamate&malate are added to isolated mitochondria or permeabilized cells, glutamate and transaminase are responsible for the metabolism of [[oxaloacetate]], comparable to the metabolism with acetyl-CoA and citrate synthase | ||
|info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 3.4]] | |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 3.4]] | ||
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Revision as of 13:19, 21 April 2016
- high-resolution terminology - matching measurements at high-resolution
GM-pathway control state
Description
MitoPathway control: CI
When glutamate&malate are added to isolated mitochondria or permeabilized cells, glutamate and transaminase are responsible for the metabolism of oxaloacetate, comparable to the metabolism with acetyl-CoA and citrate synthase
Abbreviation: GM
Reference: Gnaiger 2014 MitoPathways - Chapter 3.4
MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
GM(L)
GM(P)
GM(E)
Discussion
In human skeletal muscle mitochondria, respiration with GM in the presence of ADP (GM(P)) is identical or 10% higher than with PM (PM(P)). These results on isolated mitochondria agree with permeabilized fibres, although there are reports on respiratory capacity for PMP being 16% to 25% higher than for GM(P). In fibroblasts, GM(P) supports a higher respiratory flux than PM(P).
