Difference between revisions of "Chance 1961 J Biol Chem-III"
From Bioblast
Gnaiger Caro (talk | contribs) |
Β |
||
(One intermediate revision by one other user not shown) | |||
Line 11: | Line 11: | ||
|keywords=Pyridine nucleotide, Succinate | |keywords=Pyridine nucleotide, Succinate | ||
}} | }} | ||
== Made history == | |||
::::* [[Mitochondria and bioblasts: Made history]] | |||
{{Labeling | {{Labeling | ||
|organism=Guinea pig | |organism=Guinea pig, Birds | ||
|tissues=Heart, Kidney | |tissues=Heart, Kidney | ||
|preparations=Isolated mitochondria | |preparations=Isolated mitochondria |
Latest revision as of 10:45, 6 July 2022
Chance B, Hollunger G (1961) The interaction of energy and electron transfer reactions in mitochondria III. Substrate requirements for pyridine nucleotide reduction in mitochondria. J Biol Chem 236:1555-61. |
Chance B, Hollunger G (1961) J Biol Chem
Abstract:
- A specific succinate requirement for energy-linked reduction of mitochondrial pyridine nucleotide is demonstrated in pigeon heart and guinea pig kidney mitochondria.
- The succinate used in this reduction can be generated in the oxidation of malate plus glutamate or of Ξ±-ketoglutarate.
- The role of succinate is identified by the specific inhibitory responses of the reaction to malonate, phosphate, and fumarate.
- At least two kinds of mitochondrial pyridine nucleotide are shown to be reducible in State 4: (a) about one-third in the absence of added succinate in a malonate-insensitive reaction in the presence of a substrate such as malate plus glutamate and (b) about two-thirds in the presence of added succinate in a malonate-sensitive, energy-linked reaction. These two kinds of pyridine nucleotide may be considered to be compartmented.
β’ Keywords: Pyridine nucleotide, Succinate
Made history
Labels:
Organism: Guinea pig, Birds
Tissue;cell: Heart, Kidney
Preparation: Isolated mitochondria
Enzyme: Complex II;succinate dehydrogenase
Regulation: Substrate
Coupling state: OXPHOS
Made history