Barkova 2023 MiP203
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Link: MiPschool Obergurgl 2023
Barkova Daria (2023)
Event: MiPschool Obergurgl 2023
Introduction:
Regular exercise supports healthy ageing and reduces risk of elderly chronic diseases. Respirometry is an important tool in understanding the physiological adaptations in response to physical activity at cellular level. Previously, we showed that 3-month exercise training increases muscle metabolism in the elderly. Present study is aimed to assess the effects of long-term training on muscle oxidative capacity in the subset of individuals continuing regular training for 5 years.
Methods:
Volunteers (n=60, 66.9±1.2 years, 27.1±3.9 kg/m2) were recruited for 3-month intervention study: 36 of them underwent aerobic-strength training, 24 volunteers were active controls. A volunteer subpopulation continued aerobic-strength training for next 5 years (n=15), and is compared to non-exercising controls (n=15). Body composition, glucose tolerance, insulin sensitivity and other metabolic parameters were assessed. Samples of m. vastus lateralis obtained by biopsy were used for measurement of muscle mitochondria oxygen consumption by O2k high-resolution respirometry, applying RP1 SUIT protocol.
Results and discussion:
Three-month exercise training enhanced muscle mitochondrial respiration rate in the elderly undergoing exercise training compared to controls. So far, two individuals completed follow up phenotyping after 5 years training. A slight deterioration in anthropometric (increased BMI by ~ 8 % and visceral fat content by ~ 36%) and metabolic parameters was observed, together with a reduction in muscle mitochondrial respiration (by ~ 15 %).
Short-term training improved the whole-body and muscle metabolism in the elderly. Obtaining data from exercising and non-exercising cohorts (currently ongoing) will allow us to assess the impact of a long-term intervention.
• Keywords: Exercise, physical activity, respiration, training, elderly metabolism
Labels: MiParea: Exercise physiology;nutrition;life style
Organism: Human
Tissue;cell: Skeletal muscle
Event: E2
