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Ajime 2020 Nicotine Tob Res - Revision history
2024-03-29T06:43:29Z
Revision history for this page on the wiki
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Plangger Mario at 14:07, 6 December 2021
2021-12-06T14:07:34Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:07, 6 December 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/31965191 PMID: 31965191]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/31965191 PMID: 31965191]</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Ajime_2020_Nicotine_Tob_Res&diff=191365&oldid=prev
Plangger Mario at 15:26, 27 January 2020
2020-01-27T15:26:28Z
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Ajime_2020_Nicotine_Tob_Res&diff=191363&oldid=prev
Plangger Mario: Created page with "{{Publication |title=Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking ces..."
2020-01-27T14:51:14Z
<p>Created page with "{{Publication |title=Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking ces..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res [Epub ahead of print].<br />
|info=[https://www.ncbi.nlm.nih.gov/pubmed/31965191 PMID: 31965191]<br />
|authors=Ajime TT, Serre J, Wuest RCI, Messa GAM, Poffe C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G<br />
|year=2020<br />
|journal=Nicotine Tob Res<br />
|abstract=Apart from its adverse effects on the respiratory system, cigarette smoking also induces skeletal muscle atrophy and dysfunction. Whether short-term smoking cessation can restore muscle mass and function is unknown. We therefore studied the impact of 1- and 2-weeks smoking cessation on skeletal muscles in a mouse model.<br />
<br />
Male mice were divided into 4 groups: Air-exposed (14 weeks); cigarette smoke (CS)-exposed (14 weeks); CS-exposed (13 weeks) followed by 1-week cessation; CS-exposed (12 weeks) followed by 2 weeks cessation to examine exercise capacity, physical activity levels, body composition, muscle function, capillarization, mitochondrial function and protein expression in the soleus, plantaris and diaphragm muscles.<br />
<br />
CS-induced loss of body and muscle mass was significantly improved within 1 week of cessation due to increased lean and fat mass. Mitochondrial respiration and protein levels of the respiratory complexes in the soleus were lower in CS-exposed mice, but similar to control values after 2 weeks of cessation. Exposing isolated soleus muscles to CS extracts reduced mitochondrial respiration that was reversed after removing the extract. While physical activity was reduced in all groups, exercise capacity, limb muscle force, fatigue resistance, fiber size and capillarization and diaphragm cytoplasmic HIF-1α were unaltered by CS-exposure. However, CS-induced diaphragm atrophy and increased capillary density was not seen after 2 weeks of smoking cessation.<br />
<br />
In male mice, two weeks smoking cessation reversed smoking-induced mitochondrial dysfunction, limb muscle mass loss and diaphragm muscle atrophy, highlighting immediate benefits of cessation on skeletal muscles.<br />
<br />
<small>© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</small><br />
|keywords=CS-exposure, Smoking cessation, Mitochondrial function, Muscle mass<br />
|editor=[[Plangger M]],<br />
}}<br />
{{Labeling<br />
|area=Respiration<br />
|instruments=Oxygraph-2k<br />
|additional=Labels, 2020-01,<br />
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Plangger Mario