Stiban 2022 Abstract Bioblast: Difference between revisions
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{{Abstract | {{Abstract | ||
|title=[[File:Stiban J.jpg|left|100px|Johnny Stiban]]ย Abed Rabbo M, <u>Stiban Johnny</u> (2022) NUBPL: a mitochondrial Complex I deficiency disorder. Bioblast 2022: BEC Inaugural Conference. <br>[[Abed Rabbo 2022 MitoFit|ยป''MitoFit Preprint''ยซ]] ย | |title=[[File:Stiban J.jpg|left|100px|Johnny Stiban]]ย Abed Rabbo M, <u>Stiban Johnny</u> (2022) NUBPL: a mitochondrial Complex I deficiency disorder. Bioblast 2022: BEC Inaugural Conference. <br>[[Abed Rabbo 2022 MitoFit|ยป''MitoFit Preprint''ยซ]] ย | ||
|info=[https://wiki.oroboros.at/index.php/Bioblast_2022#Submitted_abstracts Bioblast 2022: BEC Inaugural Conference] | |info=[https://wiki.oroboros.at/index.php/Bioblast_2022#Submitted_abstracts Bioblast 2022: BEC Inaugural Conference] | ||
|authors=Abed Rabbo Muna, Stiban Johnny | |authors=Abed Rabbo Muna, Stiban Johnny | ||
|year=2022 | |year=2022 | ||
|event=[[Bioblast 2022]] | |||
|abstract=Mitochondrial ailments are diverse and devastating. Defects in mitochondrial DNA or its products lead to wide range of deficiencies in the mitochondrial electron transfer system and its ensuing energy production. Accessory proteins required for the assembly and function of the respiratory complexes are also required for healthy, coupled, and energy-producing mitochondria. Recently, the protein nucleotide binding protein like (NUBPL or IND1) was identified as an iron-sulfur cluster transfer protein specifically for Complex I. Since the presence of multiple iron-sulfur clusters in Complex I is necessary for its activity, deficiency in NUBPL leads to severely dysfunctional mitochondria, with upregulated compensatory Complex II activity. Here we present a short review of the debilitating disease related to NUBPL deficiency. | |||
|keywords=Complex I, NUBPL, IND1, iron-sulfur clusters, mtDNA helicase, bioenergetics | |keywords=Complex I, NUBPL, IND1, iron-sulfur clusters, mtDNA helicase, bioenergetics | ||
|editor= | |editor= | ||
|mipnetlab= | |mipnetlab= | ||
}} | }} | ||
== Affiliations == | == Affiliations == | ||
:::: Abed Rabbo M | :::: Abed Rabbo M<sup>1</sup>, Stiban J<sup>2</sup><sup>Superscript text</sup> | ||
::::#Department of Medical Genetics, University of British Columbia, Canada | ::::# Department of Medical Genetics, University of British Columbia, Canada | ||
::::#Department of Biology and Biochemistry, Birzeit University, Palestine - [email protected] | ::::# Department of Biology and Biochemistry, Birzeit University, Palestine - [email protected] | ||
== Help == | == Help == |
Revision as of 14:41, 22 May 2022
Abed Rabbo M, Stiban Johnny (2022) NUBPL: a mitochondrial Complex I deficiency disorder. Bioblast 2022: BEC Inaugural Conference. ยปMitoFit Preprintยซ |
Link: Bioblast 2022: BEC Inaugural Conference
Abed Rabbo Muna, Stiban Johnny (2022)
Event: Bioblast 2022
Mitochondrial ailments are diverse and devastating. Defects in mitochondrial DNA or its products lead to wide range of deficiencies in the mitochondrial electron transfer system and its ensuing energy production. Accessory proteins required for the assembly and function of the respiratory complexes are also required for healthy, coupled, and energy-producing mitochondria. Recently, the protein nucleotide binding protein like (NUBPL or IND1) was identified as an iron-sulfur cluster transfer protein specifically for Complex I. Since the presence of multiple iron-sulfur clusters in Complex I is necessary for its activity, deficiency in NUBPL leads to severely dysfunctional mitochondria, with upregulated compensatory Complex II activity. Here we present a short review of the debilitating disease related to NUBPL deficiency.
โข Keywords: Complex I, NUBPL, IND1, iron-sulfur clusters, mtDNA helicase, bioenergetics
Affiliations
- Abed Rabbo M1, Stiban J2Superscript text
- Department of Medical Genetics, University of British Columbia, Canada
- Department of Biology and Biochemistry, Birzeit University, Palestine - [email protected]
- Abed Rabbo M1, Stiban J2Superscript text
Help
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