Template:SUIT KCN: Difference between revisions

Latest revision as of 15:39, 9 April 2019

Cyanide (usually added as KCN) is a competitive inhibitor of cytochrome c oxidase (CIV).

Revision as of 13:54, 9 April 2019 (view source) Huete-Ortega Maria (talk \| contribs) No edit summary ← Older edit		Latest revision as of 15:39, 9 April 2019 (view source) Huete-Ortega Maria (talk \| contribs) No edit summary
(2 intermediate revisions by the same user not shown)
Line 1:		Line 1:
	[[Cyanide]] (usually added as KCN) is a competitive inhibitor of [[Complex_IV\| cytochrome ''c'' oxidase (CIV)]]. After inhibition the (ROX state) is normally achieved, where ''Rox'' is the [[residual oxygen consumption]] due to oxidative side reactions estimated either after inhibition or in the absence of endogenous fuel-substrates. ''Rox'' is subtracted from oxygen flux as a baseline for all respiratory states, to obtain mitochondrial respiration. In those cells where the cytochrome ''c'' oxidase pathway is not active, inhibition with [[Cyanide]] may not cause change in the ROUTINE respiration, defined as the respiration in the physiological coupling state. [[Cyanide]] inhibition is reversed by pyruvate and high oxygen levels.		[[Cyanide]] (usually added as KCN) is a competitive inhibitor of [[Complex_IV\| cytochrome ''c'' oxidase (CIV)]].