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PMS-pathway control state

From Bioblast
(Redirected from PMS)


high-resolution terminology - matching measurements at high-resolution


PMS-pathway control state

Description

PMS

PMS: Pyruvate & Malate & Succinate.

MitoPathway control: CI&II

Pyruvate (P) is oxidatively decarboxylated to acetyl-CoA and CO2, yielding NADH catalyzed by pyruvate dehydrogenase. Malate (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009).

Abbreviation: PMS

Reference: Gnaiger 2020 BEC MitoPathways

PMS
More details
ยป Additive effect of convergent electron flow
ยป Respiratory complexes - more than five
ยป Convergent electron flow
ยป NS-pathway control state

PMSL

PMS pathway in the LEAK state can be evaluated in the following SUIT protocols:

PMSP

PMS pathway in the OXPHOS state can be evaluated in the following SUIT protocols:

PMSE

PMS pathway in the ET state can be evaluated in the following SUIT protocols:


MitoPedia concepts: SUIT state