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Neu 2022 BMJ Open

From Bioblast
Publications in the MiPMap
Neu C, Skitek K, Kissler H, Baumbach P, Settmacher U, Esper Treml R, Coldewey SM (2022) Body composition, mitochondrial oxygen metabolism and metabolome of patients with obesity before and after bariatric surgery (COMMITMENT): protocol for a monocentric prospective cohort study. https://doi.org/10.1136/bmjopen-2022-062592

Β» BMJ Open 12:e062592. PMID: 35925679 Open Access

Neu Charles,  Skitek Kornel,  Kissler Hermann,  Baumbach Philipp,  Settmacher Utz,  Esper Treml Ricardo, Coldewey Sina M (2022) BMJ Open

Abstract: Obesity, defined as a body mass index β‰₯30 kg/m2, is one of the most prevalent health conditions worldwide. It is part of the metabolic syndrome, which encompasses arterial hypertension, dyslipoproteinaemia and diabetes. Obesity is viewed as a systemic disease with pathophysiological mechanisms on the molecular level. Dysfunction of the mitochondrion and systemic low-grade inflammation are among the proposed causes for the metabolic changes. In severe cases of obesity, laparoscopic sleeve gastrectomy, a bariatric operation, can achieve the desired weight loss and has been associated with clinical outcome improvement. Hitherto, the influence of patients' body composition on mitochondrial function and concomitant metabolic changes has not been fully understood. This study aims to quantify the patient's body composition before and after laparoscopic sleeve gastrectomy and to correlate these findings with changes in mitochondrial oxygen metabolism, metabolome and immune status.

In this prospective monocentric cohort study, patients undergoing laparoscopic sleeve gastrectomy (n=30) at Jena University Hospital (Germany) will be assessed before surgery and at four time points during a 1-year follow-up. Body composition will be measured by bioimpedance analysis. Non-invasive assessment of mitochondrial oxygen metabolism using protoporphyrin IX-triplet state lifetime technique (PPIX-TSLT) and blood sampling for, among other, metabolomic and immunological analysis, will be performed. The primary outcome is the difference in relative fat mass between the preoperative time point and 6 months postoperatively. Further outcomes comprise longitudinal changes of PPIX-TSLT and metabolic and immunological variables. Outcomes will be assessed using paired t-tests, Wilcoxon signed-rank tests and regression analyses. β€’ Keywords: Adult surgery, Lipid disorders, Nutrition & dietetics β€’ Bioblast editor: Plangger M


Labels: MiParea: Respiration, Patients  Pathology: Obesity 

Organism: Human  Tissue;cell: Skeletal muscle 



HRR: Oxygraph-2k 

2022-11