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Koves Timothy R

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Name Koves Timothy R, MBA, PhD, Asst. Prof.

Asst. Prof. of Medicine (Geriatrics) & Sen. Res. Fellow (Center for Aging & Human Development)

Institution Sarah W. Stedman Nutrition & Metabolism Center

Duke University Medical Center

Address 300 North Duke Street, 27704
City Durham
State/Province North Carolina (NC)
Country USA
Email [email protected]
Weblink
O2k-Network Lab US NC Durham Koves TR


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Publications

 PublishedReference
Op den Kamp 2022 Mol Metab2022Op den Kamp YJM, Gemmink A, de Ligt M, Dautzenberg B, Kornips E, Jorgensen JA, Schaart G, Esterline R, Pava DA, Hoeks J, Schrauwen-Hinderling VB, Kersten S, Havekes B, Koves TR, Muoio DM, Hesselink MKC, Oscarsson J, Phielix E, Schrauwen P (2022) Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism. https://doi.org/10.1016/j.molmet.2022.101620
Chambers 2021 JCI Insight2021Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN (2021) Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight 6:134340.
Davidson 2020 Circ Res2020Davidson MT, Grimsrud P, Lai L, Draper J, Fisher-Wellman KH, Narowski TM, Koves TR, Kelly DP, Muoio DM (2020) Extreme acetylation of the cardiac mitochondrial proteome does not promote heart failure. Circ Res 127:1094-108.
McCommis 2020 Nat Metab2020McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2:1232-47. https://doi.org/10.1038/s42255-020-00296-1
Fisher-Wellman 2019 Cell Rep2019Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.
Fisher-Wellman 2018 Cell Rep2018Fisher-Wellman KH, Davidson MT, Narowski TM, Lin CT, Koves TR, Muoio DM (2018) Mitochondrial diagnostics: A multiplexed assay platform for comprehensive assessment of mitochondrial energy fluxes. Cell Rep 24:3593-606.
Davis 2017 Tissue Eng Part C Methods2017Davis BN, Santoso JW, Walker MJ, Cheng CS, Koves TR, Kraus WE, Truskey GA (2017) Human, tissue-engineered, skeletal muscle myobundles to measure oxygen uptake and assess mitochondrial toxicity. Tissue Eng Part C Methods 23:189-99.
Huffman 2014 Diabetologia2014Huffman KM, Koves TR, Hubal MJ, Abouassi H, Beri N, Bateman LA, Stevens RD, Ilkayeva OR, Hoffman EP, Muoio DM, Kraus WE (2014) Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness. Diabetologia 57:2282-95.
Smith 2012 Biochem J2012Smith BK, Perry CG, Koves TR, Wright DC, Smith JC, Neufer PD, Muoio DM, Holloway GP (2012) Identification of a novel malonyl-CoA IC50 for CPT-I: implications for predicting in vivo fatty acid oxidation rates. Biochem J 448:13-20.

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  • The video support describing the technical aspects of operating and servicing the O2Ks are a fantastic resource for users. I have also used the troubleshooting flowchart to diagnose and self-service routine issues. The active user forums and O2k-Network serve as a rich source of protocols, shared knowledge, and information on all topics related to bioenergetics and mitochondria. (2021).