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Khairallah 2017 J Cell Biochem

From Bioblast
Publications in the MiPMap
Khairallah A, Farag AA, Johar D, Bernstein L (2017) Endocrine imbalance associated with proteome changes in diabetes. J Cell Biochem 118:3569-76.

Β» PMID: 28419534

Khairallah A, Farag AA, Johar D, Bernstein L (2017) J Cell Biochem

Abstract: The dynamics of cellular metabolism involves rapid interactions between proteins and nucleotides, proteins and proteins, proteins and mRNA, the action of miRNA, and signaling. These also involve the interactions with respect to the sulfur bond, oxygen radicals that initiate a change in conformation and a chain of events. We review a development in molecular medicine that is a very promising work in progress. We also review the current and future research methods involving mitochondria. Long-term effects of diabetes include glycation of proteins, e.g., glycohemoglobin (HbA1c), increased risk of cardiovascular diseases, atherosclerosis, retinopathy, nephropathy, and neurological dysfunctions. Tissues may be exposed to significant quantities of highly reactive chemical species including nitric oxide (NO) and reactive oxygen species over months to years. The reactions of NO can be broadly discussed with reference to three main processes which control their fate in biological systems: (1) diffusion and intra-cellular consumption; (2) autooxidation to form nitrous anhydride, N2O3; and (3) reaction with superoxide to form peroxynitrite, ONOO.-. Reactive nitrogen species produced by macrophages and neutrophils, with emphasis on NO, nitrous anhydride, peroxynitrite, and nitrogen dioxide radicals generate protein and DNA damage. Serum thiol (-SH) groups act as an important extracellular scavenger of peroxides and are therefore helpful in protecting the surrounding tissues. The events described here are a homeostatic endocrine imbalance that is associated with proteostasis. The advances we have seen in untangling this web of interactions are sure to continue at a breathtaking pace. This article is protected by copyright. All rights reserved β€’ Keywords: Endocrine, Hormone, Oxidative Stress, Proteome, Review β€’ Bioblast editor: Kandolf G


Labels: MiParea: Respiration, mtDNA;mt-genetics  Pathology: Diabetes 

Organism: Human  Tissue;cell: Blood cells, Platelet 



Pathway: ROX  HRR: Oxygraph-2k 

2017-07