Hoppel CL

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COST Action CA15203 MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Hoppel CL

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COST: Member COST WG1: WG1

Name	Hoppel Charles L, Prof., MD Professor, Pharmacology and Medicine Chief, Clinical Pharmacology Director, the Center for Mitochondrial Diseases
Institution	Department of Pharmacology, Case Western Reserve University School of Medicine, US Annual Charles L. Hoppel, M.D. Award for Outstanding Contributions in Mitochondrial Research
Address	W147 Wood Building, 10900 Euclid Avenue, 44106-4981
City	Cleveland
State/Province	Ohio (OH)
Country	USA
Email	charles.hoppel@case.edu
Weblink	Department of Pharmacology
O2k-Network Lab	US OH Cleveland Hoppel CL

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Publications

	Published	Reference
Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research 2019	2019-11-09	Cleveland, OH , 2019 Nov 09. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research.
Kumar 2019 Free Radic Biol Med	2019	Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med [Epub ahead of print].
Gnaiger 2019 MitoFit Preprint Arch	2019	Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6.
Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research 2018	2018-11-09	Cleveland, OH , 2018 Nov 09. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research.
Chen 2018 Hum Mol Genet	2018	Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26.
Hsiao 2018 Anal Biochem	2018	Hsiao CP, Hoppel C (2018) Analyzing mitochondrial function in human peripheral blood mononuclear cells. Anal Biochem 549:12-20.
The Hoppel Prize Lectureship in Mitochondrial Biology	2017-10-05	Cleveland, OH , 2017 Oct 05. The Hoppel Prize Lectureship in Mitochondrial Biology.
Zhou 2017 Biochim Biophys Acta	2017	Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5.
Davuluri 2016 J Physiol	2016	Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.
Solinas 2014 Mech Ageing Dev	2014	Solinas P, Fujioka H, Radivoyevitch T, Tandler B, Hoppel CL (2014) Aging effects on oxidative phosphorylation in rat adrenocortical 3 mitochondria. Mech Ageing Dev 138:10-4.
Ye 2013 Anal Biochem	2013	Ye F, Hoppel CL (2013) Measuring oxidative phosphorylation in human skin fibroblasts. Anal Biochem 437:52-8.
Rosca 2011 Biochim Biophys Acta	2011	Rosca M, Minkler P, Hoppel CL (2011) Cardiac mitochondria in heart failure: Normal cardiolipin profile and increased threonine phosphorylation of Complex IV. Biochim Biophys Acta 1807:1373-82.
Ye 2011 J Biol Chem	2011	Ye F, Lemieux H, Hoppel CL, Hanson RW, Hakimi P, Croniger CM, Puchowicz M, Anderson VE, Fujioka H, Stavnezer E (2011) Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski-induced shift from glycolysis to oxidative energy metabolism. J Biol Chem 286:40013-24.
Lemieux 2010 J Gerontol A Biol Sci Med Sci	2010	Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J Gerontol A Biol Sci Med Sci 65:1157-64.
Lemieux 2009 JBB	2009	Lemieux H, Hoppel CL (2009) Mitochondria in the human heart. J. Bioenerg. Biomembr. 41:99-106.
Rosca 2008 Cardiovasc Res	2008	Rosca MG, Vazquez EJ, Kerner J, Parland W, Chandler MP, Stanley W, Sabbah HN, Hoppel CL (2008) Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation. Cardiovasc Res 80:30-39.
Puchowicz 2004 Mitochondrion	2004	Puchowicz MA, Varnes ME, Cohen BH, Friedman NR, Kerr DS, Hoppel CL (2004) Oxidative phosphorylation analysis: assessing the integrated functional activity of human skeletal muscle mitochondria-case studies. Mitochondrion 4:377-85.

Abstracts

	Published	Reference
Axelrod 2019 Abstract IOC141	2019	Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02.
Hoppel 2018 MiPschool Tromso D2	2018	Mitochondrial function during ischemia/reperfusion injury.
Hoppel 2018 MiPschool Tromso D1	2018	Two populations of muscle mitochondria: heart and skeletal muscle.
Hoppel 2017 MiPschool Obergurgl E1	2017	The challenges of functional mitochondrial diagnosis.
Hoppel 2017 MiPschool Obergurgl A	2017	Biochemical coupling efficiency and ATP/O₂ ratios.
Hoppel 2017 MiP2017	2017	Pathways of mitochondrial fatty acid oxidation. Hoppel_Presentation
Hoppel 2016c Abstract MitoFit Science Camp 2016	2016	Mitochondrial respiration in permeabilized skin fibroblasts.
Hsiao 2016 Abstract MitoFit Science Camp 2016	2016	Association between mitochondrial bioenergetics and radiation-related fatigue: a possible mechanism and novel target.
Hoppel 2016a Abstract MitoFit Science Camp 2016	2016	Skeletal muscle mitochondria in diagnostic studies.
Hoppel 2016b Abstract MitoFit Science Camp 2016	2016	Comparison of permeabilized skeletal muscle fibers or isolated mitochondria for the detection of oxidative phosphorylation defects.
Lai 2014 Abstract1 MiP2014	2014	Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.
Lai 2014 Abstract2 MiP2014	2014	Bioenergetic differences between permeabilized red and white fibers of a non-obese model of type II diabetes.
Hoppel 2012 Abstract Bioblast	2012	Hoppel CL (2012) Mitochondrial functional testing – muscle biopsy, isolated mitochondria and others. Mitochondr Physiol Network 17.12.
Rosca MiP2010	2010	Rosca MG, Hoppel CL (2010) Activation of distinct mitochondrial cAMP-PKA compartments induces different effects on mitochondrial function.