Ghanim 2014 Abstract EUROMIT
|Ghanim M, Kodroń A, Tońska K, Stelmaszczyk-Emme A, Demkow U, Bartnik E (2014) Mitochondrial DNA polymorphisms in pediatric acute lymphoblastic leukemia patients.|
Over 100 mtDNA point mutations causing human disease have been detected, and more mutations are discovered every year. Numerous studies of mtDNA in cancer have shown differences in mtDNA sequences between tumor and normal tissue and at various stages of cancer treatment in the same patient. However, there are few data on acute lymphoblastic leukemia (ALL), the most common type of leukemia in children.
In this study we investigated mitochondrial sequence variation in samples of bone marrow cells and blood from eleven Polish pediatric patients collected at the time of ALL diagnosis and at various stages of chemotherapy. In five patients, the D-loop region and ND1 gene sequence were examined, whereas in the remaining six patients the whole mtDNA sequence was studied. In some patients polymorphisms whose levels varied during leukemia treatment in both coding and non-coding regions were detected.
• Keywords: mtDNA, Chemotherapy, Acute lymphoblastic leukemia (ALL) • Bioblast editor: Bufe A
Labels: MiParea: mtDNA;mt-genetics Pathology: Cancer